3KZK

Crystal structure of acetylornithine transcarbamylase complexed with acetylcitrulline

Replaces:  1YH1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004585	molecular_function	ornithine carbamoyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006591	biological_process	ornithine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0042450	biological_process	L-arginine biosynthetic process via ornithine
A	0043857	molecular_function	N-acetylornithine carbamoyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE OLN A 345

Chain	Residue
A	THR52
A	LEU295
A	PRO296
A	ARG322
A	HOH346
A	SO4349
A	HOH370
A	HOH399
A	HOH443
A	TRP77
A	GLU92
A	ARG112
A	GLU144
A	HIS148
A	GLN151
A	LYS252
A	CYS294

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 349

Chain	Residue
A	SER49
A	MET50
A	ARG51
A	THR52
A	TRP77
A	ARG112
A	OLN345

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 350

Chain	Residue
A	PHE61
A	PHE61
A	PHE61
A	HIS66
A	HIS66
A	HIS66
A	HOH342
A	HOH342
A	HOH342

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"16741992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17600144","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L02","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16741992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17600144","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KZM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L02","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3L06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16741992","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KZN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine","evidences":[{"source":"PubMed","id":"17600144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"20695527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---