3KXH

Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl-acetic acid (K66)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0004679	molecular_function	AMP-activated protein kinase activity
A	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
A	0004711	molecular_function	ribosomal protein S6 kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0035175	molecular_function	histone H3S10 kinase activity
A	0035402	molecular_function	histone H3T11 kinase activity
A	0035403	molecular_function	histone H3T6 kinase activity
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0044022	molecular_function	histone H3S28 kinase activity
A	0044023	molecular_function	histone H4S1 kinase activity
A	0044024	molecular_function	histone H2AS1 kinase activity
A	0044025	molecular_function	histone H2BS14 kinase activity
A	0051726	biological_process	regulation of cell cycle
A	0072354	molecular_function	histone H3T3 kinase activity
A	0072371	molecular_function	histone H2AS121 kinase activity
A	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
A	0106310	molecular_function	protein serine kinase activity
A	0140823	molecular_function	histone H2BS36 kinase activity
A	0140855	molecular_function	histone H3S57 kinase activity
A	0140857	molecular_function	histone H3T45 kinase activity
A	1990244	molecular_function	histone H2AT120 kinase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE K66 A 1

Chain	Residue
A	ARG47
A	ASP175
A	HOH334
A	VAL53
A	ILE66
A	LYS68
A	PHE113
A	GLU114
A	VAL116
A	MET163
A	ILE174

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 2

Chain	Residue
A	ARG191
A	VAL192
A	ALA193
A	ARG195
A	LYS198
A	HOH522

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFeGinvnnnek..........CIIK

Chain	Residue	Details
A	VAL45-LYS68

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	ASP156

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
A	VAL45
A	LYS68

---