3KVN

Crystal structure of the full-length autotransporter EstA from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006629	biological_process	lipid metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0009247	biological_process	glycolipid biosynthetic process
A	0009279	cellular_component	cell outer membrane
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0044010	biological_process	single-species biofilm formation
A	0048870	biological_process	cell motility
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0071973	biological_process	bacterial-type flagellum-dependent cell motility
A	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
A	0106435	molecular_function	carboxylesterase activity
X	0006629	biological_process	lipid metabolic process
X	0008610	biological_process	lipid biosynthetic process
X	0009247	biological_process	glycolipid biosynthetic process
X	0009279	cellular_component	cell outer membrane
X	0016298	molecular_function	lipase activity
X	0016787	molecular_function	hydrolase activity
X	0016788	molecular_function	hydrolase activity, acting on ester bonds
X	0044010	biological_process	single-species biofilm formation
X	0048870	biological_process	cell motility
X	0052689	molecular_function	carboxylic ester hydrolase activity
X	0071973	biological_process	bacterial-type flagellum-dependent cell motility
X	0071978	biological_process	bacterial-type flagellum-dependent swarming motility
X	0106435	molecular_function	carboxylesterase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE C8E X 623

Chain	Residue
X	SER14
X	LEU15
X	ASN147
X	LEU150
X	PRO188
X	LEU190
X	VAL288
X	HIS289
X	HOH767

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE C8E X 624

Chain	Residue
X	SER32
X	PHE34

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE C8E A 623

Chain	Residue
A	SER14
A	LEU15
A	GLY146
A	ASN147
A	LEU150
A	PRO188
A	LEU190
A	VAL288
A	HIS289
A	PRO290
A	HOH631

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE C8E A 624

Chain	Residue
X	HOH791

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE C8E A 625

Chain	Residue
A	PHE149
X	LEU201
X	PHE204
X	HOH770

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE C8E A 626

Chain	Residue
A	ARG112

---

Functional Information from PROSITE/UniProt

site_id	PS01098
Number of Residues	12
Details	LIPASE_GDSL_SER Lipolytic enzymes "G-D-S-L" family, serine active site. LVVFGDSLsdAG

Chain	Residue	Details
X	LEU8-GLY19

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	962
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	210
Details	Transmembrane: {"description":"Beta stranded","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	560
Details	Domain: {"description":"Autotransporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00556","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---