3KT1

Crystal structure of Tpa1 from Saccharomyces cerevisiae, a component of the messenger ribonucleoprotein complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000288	biological_process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006415	biological_process	translational termination
A	0006449	biological_process	regulation of translational termination
A	0006450	biological_process	regulation of translational fidelity
A	0008143	molecular_function	poly(A) binding
A	0008198	molecular_function	ferrous iron binding
A	0009896	biological_process	positive regulation of catabolic process
A	0010604	biological_process	positive regulation of macromolecule metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0018188	biological_process	peptidyl-proline di-hydroxylation
A	0031418	molecular_function	L-ascorbic acid binding
A	0031543	molecular_function	peptidyl-proline dioxygenase activity
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051246	biological_process	regulation of protein metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE A 653

Chain	Residue
A	HIS159
A	ASP161
A	HIS227
A	HOH797

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 654

Chain	Residue
A	ARG179
A	LYS180
A	LYS182

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 655

Chain	Residue
A	TRP546
A	TRP546
A	GLU547
A	GLU547
A	SER548
A	SER548
A	HOH764
A	HOH764
A	GLY545
A	GLY545

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 656

Chain	Residue
A	LYS152
A	VAL234
A	ASP235

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 657

Chain	Residue
A	LYS180
A	LYS182
A	SER183
A	HOH663
A	HOH855

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 658

Chain	Residue
A	GLN444
A	LYS447

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Fe2OG dioxygenase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20040577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25728928","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20040577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00805","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20040577","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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