3KMT
Crystal structure of vSET/SAH/H3 ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0062122 | molecular_function | histone H3K37 methyltransferase activity |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0062122 | molecular_function | histone H3K37 methyltransferase activity |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0062122 | molecular_function | histone H3K37 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SAH A 120 |
| Chain | Residue |
| A | LEU13 |
| A | TYR105 |
| A | TYR109 |
| A | TRP110 |
| A | THR117 |
| A | ASN119 |
| A | HOH128 |
| A | HOH136 |
| A | HOH148 |
| A | HOH159 |
| A | HOH175 |
| A | GLY14 |
| G | MLZ27 |
| A | GLY15 |
| A | TYR16 |
| A | ASP49 |
| A | TYR50 |
| A | ILE67 |
| A | ASN69 |
| A | HIS70 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH B 120 |
| Chain | Residue |
| B | LEU13 |
| B | GLY14 |
| B | GLY15 |
| B | TYR16 |
| B | ASP49 |
| B | TYR50 |
| B | ILE67 |
| B | ASN69 |
| B | HIS70 |
| B | TYR105 |
| B | TYR109 |
| B | TRP110 |
| B | THR117 |
| B | ASN119 |
| B | HOH124 |
| B | HOH127 |
| H | MLZ27 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAH C 120 |
| Chain | Residue |
| A | LYS26 |
| A | HOH160 |
| C | LEU13 |
| C | GLY14 |
| C | GLY15 |
| C | TYR16 |
| C | ASP49 |
| C | TYR50 |
| C | ILE67 |
| C | ASN69 |
| C | HIS70 |
| C | TYR105 |
| C | TYR109 |
| C | TRP110 |
| C | THR117 |
| C | ASN119 |
| C | HOH123 |
| C | HOH129 |
| C | HOH148 |
| C | HOH199 |
| I | MLZ27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| G | ARG26 | |
| H | ARG26 | |
| I | ARG26 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| G | MLZ27 | |
| H | MLZ27 | |
| I | MLZ27 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| G | SER28 | |
| H | SER28 | |
| I | SER28 |
