3KJY
Crystal structure of reduced HOMO SAPIENS CLIC3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005254 | molecular_function | chloride channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016604 | cellular_component | nuclear body |
| A | 0019153 | molecular_function | protein-disulfide reductase (glutathione) activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034707 | cellular_component | chloride channel complex |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
| B | 0005254 | molecular_function | chloride channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016604 | cellular_component | nuclear body |
| B | 0019153 | molecular_function | protein-disulfide reductase (glutathione) activity |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0034707 | cellular_component | chloride channel complex |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1903672 | biological_process | positive regulation of sprouting angiogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 231 |
| Chain | Residue |
| A | ARG27 |
| A | LEU76 |
| A | HOH239 |
| A | HOH265 |
| B | LYS111 |
| B | GLN130 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 232 |
| Chain | Residue |
| B | ALA197 |
| B | GLU198 |
| A | HIS221 |
| A | SER222 |
| B | PRO196 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 233 |
| Chain | Residue |
| A | LYS111 |
| A | HOH236 |
| B | ARG27 |
| B | LEU76 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 234 |
| Chain | Residue |
| A | ARG97 |
| A | HIS148 |
| A | GLY166 |
| A | ASP167 |
| A | ARG168 |
| A | HOH253 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 235 |
| Chain | Residue |
| A | PHE109 |
| A | HIS110 |
| A | LYS179 |
| A | HOH245 |
| B | HIS110 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 231 |
| Chain | Residue |
| A | HIS110 |
| B | HIS110 |
| B | LYS179 |
| B | HOH250 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 232 |
| Chain | Residue |
| B | ARG133 |
| B | ARG137 |
| B | HOH289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Motif: {"description":"G-site","evidences":[{"source":"PubMed","id":"28198360","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37759794","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | VAL10 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| B | VAL10 |
