3KI8
Crystal structure of hyperthermophilic nitrilase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000257 | molecular_function | nitrilase activity |
| A | 0003837 | molecular_function | beta-ureidopropionase activity |
| A | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| A | 0033396 | biological_process | beta-alanine biosynthetic process via 3-ureidopropionate |
| A | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| A | 0080061 | molecular_function | indole-3-acetonitrile nitrilase activity |
| B | 0000257 | molecular_function | nitrilase activity |
| B | 0003837 | molecular_function | beta-ureidopropionase activity |
| B | 0006807 | biological_process | obsolete nitrogen compound metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0033388 | biological_process | putrescine biosynthetic process from arginine |
| B | 0033396 | biological_process | beta-alanine biosynthetic process via 3-ureidopropionate |
| B | 0050126 | molecular_function | N-carbamoylputrescine amidase activity |
| B | 0080061 | molecular_function | indole-3-acetonitrile nitrilase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY A 3001 |
| Chain | Residue |
| A | CSD146 |
| A | TRP149 |
| A | LEU172 |
| A | VAL173 |
| A | MET174 |
| A | HOH289 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 3004 |
| Chain | Residue |
| A | ARG132 |
| A | VAL133 |
| A | HOH314 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 263 |
| Chain | Residue |
| A | HOH372 |
| A | HOH380 |
| A | HOH428 |
| A | HOH429 |
| A | HOH430 |
| A | HOH431 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 3002 |
| Chain | Residue |
| B | CSD146 |
| B | TRP149 |
| B | LEU172 |
| B | VAL173 |
| B | MET174 |
| B | HOH267 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACY B 3003 |
| Chain | Residue |
| B | TYR118 |
| B | LEU204 |
| B | HOH289 |
| B | HOH322 |
| B | HOH398 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 263 |
| Chain | Residue |
| B | ASN49 |
| B | HOH264 |
| B | HOH322 |
| B | HOH323 |
| B | HOH324 |
| B | HOH398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21095228 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21095228 |
| Chain | Residue | Details |
| A | LYS113 | |
| B | LYS113 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000269|PubMed:21095228 |
| Chain | Residue | Details |
| A | CSD146 | |
| B | CSD146 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL173 | |
| B | VAL173 |
