3KHB

Crystal structure of Escherichia coli AlkB with Co(II) and 2-OG

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0006974	biological_process	DNA damage response
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0035513	biological_process	oxidative RNA demethylation
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0042245	biological_process	RNA repair
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0070989	biological_process	oxidative demethylation
A	0072702	biological_process	response to methyl methanesulfonate
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006307	biological_process	DNA alkylation repair
B	0006974	biological_process	DNA damage response
B	0008198	molecular_function	ferrous iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0035513	biological_process	oxidative RNA demethylation
B	0035515	molecular_function	oxidative RNA demethylase activity
B	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
B	0042245	biological_process	RNA repair
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
B	0070989	biological_process	oxidative demethylation
B	0072702	biological_process	response to methyl methanesulfonate

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO A 1001

Chain	Residue
A	HIS131
A	ASP133
A	HIS187
A	AKG400

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AKG A 400

Chain	Residue
A	SER145
A	HIS187
A	ILE189
A	ARG204
A	ASN206
A	THR208
A	ARG210
A	HOH232
A	CO1001
A	ASN120
A	TYR122
A	LEU128
A	HIS131
A	ASP133

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO B 1002

Chain	Residue
B	HIS131
B	ASP133
B	HIS187
B	AKG401

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AKG B 401

Chain	Residue
B	LEU118
B	ASN120
B	TYR122
B	LEU128
B	HIS131
B	ASP133
B	ILE189
B	ARG204
B	ASN206
B	THR208
B	ARG210
B	CO1002

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:16482161, ECO:0000269|PubMed:20084272

Chain	Residue	Details
A	TRP69
A	ASP135
A	ARG161
B	TRP69
B	ASP135
B	ARG161

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	TYR76
A	ASN120
A	ARG204
B	TYR76
B	ASN120
B	ARG204

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:16482161

Chain	Residue	Details
A	HIS131
A	ASP133
A	HIS187
B	HIS131
B	ASP133
B	HIS187

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