3KGB

Crystal structure of thymidylate synthase 1/2 from Encephalitozoon cuniculi at 2.2 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 300

Chain	Residue
A	GLY199
A	VAL236
A	TYR237
A	HIS240

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Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriVvsaWNptdlgsma.....LpPCHvlfQFnV

Chain	Residue	Details
A	ARG154-VAL182

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
A	CYS174

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
A	ARG29
A	ARG194
A	ASN205
A	HIS235

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
A	ARG154
A	ASP197

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1b02

Chain	Residue	Details
A	SER208
A	CYS174
A	ASN205

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site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1b02

Chain	Residue	Details
A	SER195
A	CYS174
A	ASP197
A	GLU67
A	ASP233
A	HIS235

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