3KER
D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002020 | molecular_function | protease binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016829 | molecular_function | lyase activity |
| A | 0033981 | molecular_function | D-dopachrome decarboxylase activity |
| A | 0042438 | biological_process | melanin biosynthetic process |
| A | 0050178 | molecular_function | phenylpyruvate tautomerase activity |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| B | 0002020 | molecular_function | protease binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016829 | molecular_function | lyase activity |
| B | 0033981 | molecular_function | D-dopachrome decarboxylase activity |
| B | 0042438 | biological_process | melanin biosynthetic process |
| B | 0050178 | molecular_function | phenylpyruvate tautomerase activity |
| B | 0050729 | biological_process | positive regulation of inflammatory response |
| C | 0002020 | molecular_function | protease binding |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016829 | molecular_function | lyase activity |
| C | 0033981 | molecular_function | D-dopachrome decarboxylase activity |
| C | 0042438 | biological_process | melanin biosynthetic process |
| C | 0050178 | molecular_function | phenylpyruvate tautomerase activity |
| C | 0050729 | biological_process | positive regulation of inflammatory response |
| D | 0002020 | molecular_function | protease binding |
| D | 0005615 | cellular_component | extracellular space |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016829 | molecular_function | lyase activity |
| D | 0033981 | molecular_function | D-dopachrome decarboxylase activity |
| D | 0042438 | biological_process | melanin biosynthetic process |
| D | 0050178 | molecular_function | phenylpyruvate tautomerase activity |
| D | 0050729 | biological_process | positive regulation of inflammatory response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE RW1 A 120 |
| Chain | Residue |
| A | PRO1 |
| A | PHE2 |
| A | PRO33 |
| A | ARG36 |
| A | ILE107 |
| A | LYS109 |
| A | MET114 |
| A | CL118 |
| D | LEU117 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 118 |
| Chain | Residue |
| A | PRO1 |
| A | LYS32 |
| A | SER63 |
| A | ILE64 |
| A | RW1120 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 119 |
| Chain | Residue |
| A | PRO10 |
| A | ALA11 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 121 |
| Chain | Residue |
| A | THR46 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 122 |
| Chain | Residue |
| A | ASN8 |
| A | THR46 |
| A | LEU47 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE RW1 B 120 |
| Chain | Residue |
| B | PRO1 |
| B | PHE2 |
| B | PRO33 |
| B | ARG36 |
| B | ILE107 |
| B | LYS109 |
| B | MET114 |
| B | CL118 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 118 |
| Chain | Residue |
| B | PRO1 |
| B | LYS32 |
| B | SER63 |
| B | ILE64 |
| B | RW1120 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 119 |
| Chain | Residue |
| B | PRO10 |
| B | ALA11 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA B 121 |
| Chain | Residue |
| A | PRO43 |
| B | THR46 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 122 |
| Chain | Residue |
| B | ASN8 |
| B | THR46 |
| B | LEU47 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE RW1 C 120 |
| Chain | Residue |
| B | LEU117 |
| C | PRO1 |
| C | PHE2 |
| C | PRO33 |
| C | ARG36 |
| C | ILE107 |
| C | LYS109 |
| C | MET114 |
| C | CL118 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 118 |
| Chain | Residue |
| C | PRO1 |
| C | LYS32 |
| C | SER63 |
| C | ILE64 |
| C | RW1120 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 119 |
| Chain | Residue |
| C | PRO10 |
| C | ALA11 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA C 121 |
| Chain | Residue |
| C | THR46 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 122 |
| Chain | Residue |
| C | ASN8 |
| C | THR46 |
| C | LEU47 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE RW1 D 120 |
| Chain | Residue |
| D | PRO1 |
| D | PHE2 |
| D | PRO33 |
| D | ARG36 |
| D | ILE107 |
| D | LYS109 |
| D | MET114 |
| D | CL118 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 118 |
| Chain | Residue |
| D | PRO1 |
| D | LYS32 |
| D | SER63 |
| D | ILE64 |
| D | RW1120 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 119 |
| Chain | Residue |
| D | PRO10 |
| D | ALA11 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA D 121 |
| Chain | Residue |
| D | THR46 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 122 |
| Chain | Residue |
| D | ASN8 |
| D | THR46 |
| D | LEU47 |
Functional Information from PROSITE/UniProt
| site_id | PS01158 |
| Number of Residues | 15 |
| Details | MIF Macrophage migration inhibitory factor family signature. EPCAhllVsSIGvVG |
| Chain | Residue | Details |
| A | GLU54-GLY68 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylproline => ECO:0000269|Ref.4 |
| Chain | Residue | Details |
| A | PRO1 | |
| B | PRO1 | |
| C | PRO1 | |
| D | PRO1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS32 | |
| B | LYS32 | |
| C | LYS32 | |
| D | LYS32 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P80254 |
| Chain | Residue | Details |
| A | SER89 | |
| B | SER89 | |
| C | SER89 | |
| D | SER89 |
