3KER

D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with inhibitor 4-IPP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0005126	molecular_function	cytokine receptor binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0016829	molecular_function	lyase activity
A	0033981	molecular_function	D-dopachrome decarboxylase activity
A	0042438	biological_process	melanin biosynthetic process
A	0050178	molecular_function	phenylpyruvate tautomerase activity
A	0050729	biological_process	positive regulation of inflammatory response
B	0002020	molecular_function	protease binding
B	0005126	molecular_function	cytokine receptor binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0016829	molecular_function	lyase activity
B	0033981	molecular_function	D-dopachrome decarboxylase activity
B	0042438	biological_process	melanin biosynthetic process
B	0050178	molecular_function	phenylpyruvate tautomerase activity
B	0050729	biological_process	positive regulation of inflammatory response
C	0002020	molecular_function	protease binding
C	0005126	molecular_function	cytokine receptor binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0016829	molecular_function	lyase activity
C	0033981	molecular_function	D-dopachrome decarboxylase activity
C	0042438	biological_process	melanin biosynthetic process
C	0050178	molecular_function	phenylpyruvate tautomerase activity
C	0050729	biological_process	positive regulation of inflammatory response
D	0002020	molecular_function	protease binding
D	0005126	molecular_function	cytokine receptor binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0016829	molecular_function	lyase activity
D	0033981	molecular_function	D-dopachrome decarboxylase activity
D	0042438	biological_process	melanin biosynthetic process
D	0050178	molecular_function	phenylpyruvate tautomerase activity
D	0050729	biological_process	positive regulation of inflammatory response

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RW1 A 120

Chain	Residue
A	PRO1
A	PHE2
A	PRO33
A	ARG36
A	ILE107
A	LYS109
A	MET114
A	CL118
D	LEU117

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 118

Chain	Residue
A	PRO1
A	LYS32
A	SER63
A	ILE64
A	RW1120

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 119

Chain	Residue
A	PRO10
A	ALA11

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 121

Chain	Residue
A	THR46

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 122

Chain	Residue
A	ASN8
A	THR46
A	LEU47

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RW1 B 120

Chain	Residue
B	PRO1
B	PHE2
B	PRO33
B	ARG36
B	ILE107
B	LYS109
B	MET114
B	CL118

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL B 118

Chain	Residue
B	PRO1
B	LYS32
B	SER63
B	ILE64
B	RW1120

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 119

Chain	Residue
B	PRO10
B	ALA11

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA B 121

Chain	Residue
A	PRO43
B	THR46

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 122

Chain	Residue
B	ASN8
B	THR46
B	LEU47

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RW1 C 120

Chain	Residue
B	LEU117
C	PRO1
C	PHE2
C	PRO33
C	ARG36
C	ILE107
C	LYS109
C	MET114
C	CL118

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 118

Chain	Residue
C	PRO1
C	LYS32
C	SER63
C	ILE64
C	RW1120

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 119

Chain	Residue
C	PRO10
C	ALA11

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 121

Chain	Residue
C	THR46

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 122

Chain	Residue
C	ASN8
C	THR46
C	LEU47

---

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RW1 D 120

Chain	Residue
D	PRO1
D	PHE2
D	PRO33
D	ARG36
D	ILE107
D	LYS109
D	MET114
D	CL118

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 118

Chain	Residue
D	PRO1
D	LYS32
D	SER63
D	ILE64
D	RW1120

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 119

Chain	Residue
D	PRO10
D	ALA11

---

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA D 121

Chain	Residue
D	THR46

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 122

Chain	Residue
D	ASN8
D	THR46
D	LEU47

---

Functional Information from PROSITE/UniProt

site_id	PS01158
Number of Residues	15
Details	MIF Macrophage migration inhibitory factor family signature. EPCAhllVsSIGvVG

Chain	Residue	Details
A	GLU54-GLY68

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"N-acetylproline","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P80254","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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