3KEL
Crystal Structure of IspH:PP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0051745 | molecular_function | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050992 | biological_process | dimethylallyl diphosphate biosynthetic process |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051538 | molecular_function | 3 iron, 4 sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0051745 | molecular_function | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F3S A 997 |
| Chain | Residue |
| A | CYS12 |
| A | GLY14 |
| A | VAL15 |
| A | CYS96 |
| A | LEU98 |
| A | THR167 |
| A | CYS197 |
| A | HOH321 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE POP A 998 |
| Chain | Residue |
| A | HIS41 |
| A | HIS74 |
| A | HIS124 |
| A | THR168 |
| A | ASN224 |
| A | SER225 |
| A | SER226 |
| A | ASN227 |
| A | SER269 |
| A | HOH342 |
| A | HOH382 |
| A | HOH443 |
| A | VAL40 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE F3S B 997 |
| Chain | Residue |
| B | CYS12 |
| B | GLY14 |
| B | VAL15 |
| B | CYS96 |
| B | LEU98 |
| B | THR167 |
| B | CYS197 |
| B | HOH328 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE POP B 998 |
| Chain | Residue |
| B | VAL40 |
| B | HIS41 |
| B | HIS74 |
| B | HIS124 |
| B | THR168 |
| B | ASN224 |
| B | SER225 |
| B | SER226 |
| B | ASN227 |
| B | SER269 |
| B | HOH326 |
| B | HOH365 |
| B | HOH428 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"22137895","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22687151","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20080550","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22137895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22687151","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22948824","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23307751","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3URK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H4C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20080550","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3KEM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20080550","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22137895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22687151","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3KE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SZL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EB3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
