3KEE
HCV NS3/NS4A complexed with Non-covalent macrocyclic compound TMC435
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0019087 | biological_process | symbiont-mediated transformation of host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 30B A 500 |
| Chain | Residue |
| A | GLN41 |
| A | LEU135 |
| A | LYS136 |
| A | GLY137 |
| A | SER139 |
| A | PHE154 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | CYS159 |
| A | ASP168 |
| A | PHE43 |
| C | ASP79 |
| C | 30B500 |
| A | TYR56 |
| A | HIS57 |
| A | GLY58 |
| A | VAL78 |
| A | ASP79 |
| A | ASP81 |
| A | VAL132 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 30B B 500 |
| Chain | Residue |
| B | GLN41 |
| B | PHE43 |
| B | TYR56 |
| B | HIS57 |
| B | GLY58 |
| B | ASP81 |
| B | LEU135 |
| B | LYS136 |
| B | GLY137 |
| B | SER138 |
| B | SER139 |
| B | PHE154 |
| B | ARG155 |
| B | ALA156 |
| B | ALA157 |
| B | HOH197 |
| D | VAL78 |
| D | 30B500 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 30B C 500 |
| Chain | Residue |
| A | VAL78 |
| A | 30B500 |
| C | GLN41 |
| C | PHE43 |
| C | TYR56 |
| C | HIS57 |
| C | GLY58 |
| C | ASP79 |
| C | ASP81 |
| C | LEU135 |
| C | LYS136 |
| C | GLY137 |
| C | SER139 |
| C | PHE154 |
| C | ARG155 |
| C | ALA156 |
| C | ALA157 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 30B D 500 |
| Chain | Residue |
| B | ASP79 |
| B | 30B500 |
| D | GLN41 |
| D | PHE43 |
| D | TYR56 |
| D | HIS57 |
| D | GLY58 |
| D | VAL78 |
| D | ASP79 |
| D | ASP81 |
| D | VAL132 |
| D | LEU135 |
| D | LYS136 |
| D | GLY137 |
| D | SER139 |
| D | PHE154 |
| D | ARG155 |
| D | ALA156 |
| D | ALA157 |
| D | ASP168 |
| D | HOH195 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 2000 |
| Chain | Residue |
| A | CYS97 |
| A | CYS99 |
| A | CYS145 |
| A | HOH190 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2000 |
| Chain | Residue |
| B | CYS97 |
| B | CYS99 |
| B | CYS145 |
| B | HOH190 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 2000 |
| Chain | Residue |
| C | CYS97 |
| C | CYS99 |
| C | CYS145 |
| C | HOH190 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 2000 |
| Chain | Residue |
| D | CYS97 |
| D | CYS99 |
| D | CYS145 |
| D | HOH190 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 3968 |
| Chain | Residue |
| A | ARG109 |
| A | ARG109 |
| A | HIS110 |
| C | ARG109 |
| C | ARG109 |
| C | HIS110 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 3968 |
| Chain | Residue |
| B | ARG109 |
| B | ARG109 |
| B | HIS110 |
| D | ARG109 |
| D | ARG109 |
| D | HIS110 |
| D | HIS110 |
