3KEE
HCV NS3/NS4A complexed with Non-covalent macrocyclic compound TMC435
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0019087 | biological_process | transformation of host cell by virus |
B | 0006508 | biological_process | proteolysis |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0019087 | biological_process | transformation of host cell by virus |
C | 0006508 | biological_process | proteolysis |
C | 0008236 | molecular_function | serine-type peptidase activity |
C | 0019087 | biological_process | transformation of host cell by virus |
D | 0006508 | biological_process | proteolysis |
D | 0008236 | molecular_function | serine-type peptidase activity |
D | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 30B A 500 |
Chain | Residue |
A | GLN41 |
A | LEU135 |
A | LYS136 |
A | GLY137 |
A | SER139 |
A | PHE154 |
A | ARG155 |
A | ALA156 |
A | ALA157 |
A | CYS159 |
A | ASP168 |
A | PHE43 |
C | ASP79 |
C | 30B500 |
A | TYR56 |
A | HIS57 |
A | GLY58 |
A | VAL78 |
A | ASP79 |
A | ASP81 |
A | VAL132 |
site_id | AC2 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE 30B B 500 |
Chain | Residue |
B | GLN41 |
B | PHE43 |
B | TYR56 |
B | HIS57 |
B | GLY58 |
B | ASP81 |
B | LEU135 |
B | LYS136 |
B | GLY137 |
B | SER138 |
B | SER139 |
B | PHE154 |
B | ARG155 |
B | ALA156 |
B | ALA157 |
B | HOH197 |
D | VAL78 |
D | 30B500 |
site_id | AC3 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 30B C 500 |
Chain | Residue |
A | VAL78 |
A | 30B500 |
C | GLN41 |
C | PHE43 |
C | TYR56 |
C | HIS57 |
C | GLY58 |
C | ASP79 |
C | ASP81 |
C | LEU135 |
C | LYS136 |
C | GLY137 |
C | SER139 |
C | PHE154 |
C | ARG155 |
C | ALA156 |
C | ALA157 |
site_id | AC4 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE 30B D 500 |
Chain | Residue |
B | ASP79 |
B | 30B500 |
D | GLN41 |
D | PHE43 |
D | TYR56 |
D | HIS57 |
D | GLY58 |
D | VAL78 |
D | ASP79 |
D | ASP81 |
D | VAL132 |
D | LEU135 |
D | LYS136 |
D | GLY137 |
D | SER139 |
D | PHE154 |
D | ARG155 |
D | ALA156 |
D | ALA157 |
D | ASP168 |
D | HOH195 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 2000 |
Chain | Residue |
A | CYS97 |
A | CYS99 |
A | CYS145 |
A | HOH190 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2000 |
Chain | Residue |
B | CYS97 |
B | CYS99 |
B | CYS145 |
B | HOH190 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 2000 |
Chain | Residue |
C | CYS97 |
C | CYS99 |
C | CYS145 |
C | HOH190 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 2000 |
Chain | Residue |
D | CYS97 |
D | CYS99 |
D | CYS145 |
D | HOH190 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL C 3968 |
Chain | Residue |
A | ARG109 |
A | ARG109 |
A | HIS110 |
C | ARG109 |
C | ARG109 |
C | HIS110 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL D 3968 |
Chain | Residue |
B | ARG109 |
B | ARG109 |
B | HIS110 |
D | ARG109 |
D | ARG109 |
D | HIS110 |
D | HIS110 |