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3KDU

Crystal structure of peroxisome proliferator-activatedeceptor alpha (PPARalpha) complex with N-3-((2-(4-Chlorophenyl)-5-methyl-1,3-oxazol-4-yl)methoxy)benzyl)-N-((4-methylphenoxy)carbonyl)glycine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE NKS A 501
ChainResidue
AHOH188
AILE354
AMET355
AHIS440
ALEU460
ATYR464
ALEU247
AILE272
APHE273
ACYS276
ASER280
ATYR314
AMET330
AVAL332

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE NKS B 501
ChainResidue
BVAL255
BPHE273
BCYS276
BSER280
BTYR314
BMET330
BVAL332
BILE354
BMET355
BHIS440
BLEU460
BTYR464

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1
ChainResidueDetails
ASER280
ATYR314
ATYR464
BSER280
BTYR314
BTYR464

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for heterodimerization with RXRA
ChainResidueDetails
ALEU433
BLEU433

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PDB entries from 2024-05-01

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