Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3KC3

MK2 complexed to inhibitor N4-(7-(benzofuran-2-yl)-1H-indazol-5-yl)pyrimidine-2,4-diamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
E	0004672	molecular_function	protein kinase activity
E	0005524	molecular_function	ATP binding
E	0006468	biological_process	protein phosphorylation
F	0004672	molecular_function	protein kinase activity
F	0005524	molecular_function	ATP binding
F	0006468	biological_process	protein phosphorylation
G	0004672	molecular_function	protein kinase activity
G	0005524	molecular_function	ATP binding
G	0006468	biological_process	protein phosphorylation
H	0004672	molecular_function	protein kinase activity
H	0005524	molecular_function	ATP binding
H	0006468	biological_process	protein phosphorylation
I	0004672	molecular_function	protein kinase activity
I	0005524	molecular_function	ATP binding
I	0006468	biological_process	protein phosphorylation
J	0004672	molecular_function	protein kinase activity
J	0005524	molecular_function	ATP binding
J	0006468	biological_process	protein phosphorylation
K	0004672	molecular_function	protein kinase activity
K	0005524	molecular_function	ATP binding
K	0006468	biological_process	protein phosphorylation
L	0004672	molecular_function	protein kinase activity
L	0005524	molecular_function	ATP binding
L	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MK2 A 500

Chain	Residue
A	LEU70
A	THR206
A	ASP207
A	VAL78
A	LYS93
A	HIS108
A	MET138
A	GLU139
A	LEU141
A	ASP142
A	LEU193

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MK2 B 500

Chain	Residue
B	LEU70
B	VAL78
B	ALA91
B	LYS93
B	MET138
B	GLU139
B	LEU141
B	GLY144
B	LEU193
B	THR206
B	ASP207

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MK2 C 500

Chain	Residue
C	LEU70
C	ALA91
C	LYS93
C	MET138
C	GLU139
C	LEU141
C	LEU193
C	THR206
C	ASP207

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MK2 D 500

Chain	Residue
D	LEU70
D	VAL78
D	LYS93
D	MET138
D	GLU139
D	LEU141
D	ASP142
D	LEU193
D	THR206
D	ASP207

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MK2 E 500

Chain	Residue
E	ALA91
E	LYS93
E	MET138
E	GLU139
E	CYS140
E	LEU141
E	ASP142
E	GLU145
E	LEU193
E	THR206
E	ASP207

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MK2 F 500

Chain	Residue
F	LEU70
F	VAL78
F	ALA91
F	LYS93
F	HIS108
F	MET138
F	GLU139
F	LEU141
F	ASP142
F	LEU193
F	THR206
F	ASP207

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MK2 H 500

Chain	Residue
H	LEU70
H	VAL78
H	LYS93
H	MET138
H	GLU139
H	LEU141
H	ASP142
H	LEU193
H	THR206
H	ASP207

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MK2 I 500

Chain	Residue
I	LEU70
I	GLY71
I	GLY73
I	VAL78
I	LYS93
I	MET138
I	GLU139
I	LEU141
I	ASP142
I	GLY144
I	LEU193
I	THR206
I	ASP207

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MK2 J 500

Chain	Residue
J	LEU70
J	VAL78
J	LYS93
J	MET138
J	LEU141
J	ASP142
J	LEU193
J	THR206
J	ASP207

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MK2 K 500

Chain	Residue
K	LYS93
K	MET138
K	GLU139
K	LEU141
K	ASP142
K	GLY144
K	LEU193
K	THR206
K	ASP207
K	LEU70
K	GLY71
K	ALA91

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MK2 L 500

Chain	Residue
L	LEU70
L	VAL78
L	LYS93
L	HIS108
L	MET138
L	GLU139
L	LEU141
L	GLY144
L	THR206
L	ASP207

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK

Chain	Residue	Details
A	LEU70-LYS93

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY

Chain	Residue	Details
A	ILE182-TYR194

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	108
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)