3KBH

Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008241	molecular_function	peptidyl-dipeptidase activity
A	0016020	cellular_component	membrane
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008241	molecular_function	peptidyl-dipeptidase activity
B	0016020	cellular_component	membrane
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
C	0008241	molecular_function	peptidyl-dipeptidase activity
C	0016020	cellular_component	membrane
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008241	molecular_function	peptidyl-dipeptidase activity
D	0016020	cellular_component	membrane
E	0019064	biological_process	fusion of virus membrane with host plasma membrane
F	0019064	biological_process	fusion of virus membrane with host plasma membrane
G	0019064	biological_process	fusion of virus membrane with host plasma membrane
H	0019064	biological_process	fusion of virus membrane with host plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ

Chain	Residue	Details
A	THR371-GLN380

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:19901337, ECO:0000269|PubMed:27617430

Chain	Residue	Details
E	ASN486
E	ASN512
F	ASN486
F	ASN512
G	ASN486
G	ASN512
H	ASN486
H	ASN512

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc) asparagine; by host => ECO:0000269|PubMed:27617430

Chain	Residue	Details
E	ASN506
F	ASN506
G	ASN506
H	ASN506

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site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895, ECO:0000305|PubMed:19021774

Chain	Residue	Details
A	ARG169
D	ARG169
D	TRP477
D	LYS481
A	TRP477
A	LYS481
B	ARG169
B	TRP477
B	LYS481
C	ARG169
C	TRP477
C	LYS481

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site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING: BINDING => ECO:0000305|PubMed:14754895

Chain	Residue	Details
A	ARG273
D	ARG273
D	HIS345
D	TYR515
A	HIS345
A	TYR515
B	ARG273
B	HIS345
B	TYR515
C	ARG273
C	HIS345
C	TYR515

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site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01355, ECO:0000269|PubMed:14754895

Chain	Residue	Details
A	HIS374
D	HIS374
D	HIS378
D	GLU402
A	HIS378
A	GLU402
B	HIS374
B	HIS378
B	GLU402
C	HIS374
C	HIS378
C	GLU402

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site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:14754895

Chain	Residue	Details
A	ASN53
A	ASN322
B	ASN53
B	ASN322
C	ASN53
C	ASN322
D	ASN53
D	ASN322

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site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:19901337

Chain	Residue	Details
A	ASN90
B	ASN90
C	ASN90
D	ASN90

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site_id	SWS_FT_FI8
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895

Chain	Residue	Details
A	ASN103
A	ASN432
B	ASN103
B	ASN432
C	ASN103
C	ASN432
D	ASN103
D	ASN432

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site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14754895, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19901337

Chain	Residue	Details
A	ASN546
B	ASN546
C	ASN546
D	ASN546

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