3K9Y

Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CYMAL-5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001649	biological_process	osteoblast differentiation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005739	cellular_component	mitochondrion
A	0006629	biological_process	lipid metabolic process
A	0006706	biological_process	steroid catabolic process
A	0008403	molecular_function	25-hydroxycholecalciferol-24-hydroxylase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0030342	molecular_function	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
A	0030343	molecular_function	vitamin D3 25-hydroxylase activity
A	0033280	biological_process	response to vitamin D
A	0036378	biological_process	calcitriol biosynthetic process from calciol
A	0042359	biological_process	vitamin D metabolic process
A	0042369	biological_process	vitamin D catabolic process
A	0046872	molecular_function	metal ion binding
A	0062180	molecular_function	25-hydroxycholecalciferol-23-hydroxylase activity
A	0062181	molecular_function	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
A	0070576	molecular_function	vitamin D 24-hydroxylase activity
A	0071305	biological_process	cellular response to vitamin D
B	0001649	biological_process	osteoblast differentiation
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005739	cellular_component	mitochondrion
B	0006629	biological_process	lipid metabolic process
B	0006706	biological_process	steroid catabolic process
B	0008403	molecular_function	25-hydroxycholecalciferol-24-hydroxylase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0030342	molecular_function	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
B	0030343	molecular_function	vitamin D3 25-hydroxylase activity
B	0033280	biological_process	response to vitamin D
B	0036378	biological_process	calcitriol biosynthetic process from calciol
B	0042359	biological_process	vitamin D metabolic process
B	0042369	biological_process	vitamin D catabolic process
B	0046872	molecular_function	metal ion binding
B	0062180	molecular_function	25-hydroxycholecalciferol-23-hydroxylase activity
B	0062181	molecular_function	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
B	0070576	molecular_function	vitamin D 24-hydroxylase activity
B	0071305	biological_process	cellular response to vitamin D

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CM5 A 516

Chain	Residue
A	MET246
A	SER247
A	PHE249
A	CM5517

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CM5 A 517

Chain	Residue
A	GLN82
A	PHE393
A	HIS497
A	CM5516
B	LEU66

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGiGKRMCIG

Chain	Residue	Details
A	PHE455-GLY464

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PDB","id":"3K9V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K9Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	GLU329
A	THR330

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
B	GLU329
B	THR330

---