3K9V

Crystal structure of rat mitochondrial P450 24A1 S57D in complex with CHAPS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001649	biological_process	osteoblast differentiation
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005739	cellular_component	mitochondrion
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008403	molecular_function	25-hydroxycholecalciferol-24-hydroxylase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0030342	molecular_function	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
A	0033280	biological_process	response to vitamin D
A	0042359	biological_process	vitamin D metabolic process
A	0042369	biological_process	vitamin D catabolic process
A	0046872	molecular_function	metal ion binding
A	0062180	molecular_function	25-hydroxycholecalciferol-23-hydroxylase activity
A	0062181	molecular_function	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
A	0070576	molecular_function	vitamin D 24-hydroxylase activity
A	0070643	molecular_function	vitamin D 25-hydroxylase activity
A	0071305	biological_process	cellular response to vitamin D
B	0001649	biological_process	osteoblast differentiation
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005739	cellular_component	mitochondrion
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0008403	molecular_function	25-hydroxycholecalciferol-24-hydroxylase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0030342	molecular_function	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
B	0033280	biological_process	response to vitamin D
B	0042359	biological_process	vitamin D metabolic process
B	0042369	biological_process	vitamin D catabolic process
B	0046872	molecular_function	metal ion binding
B	0062180	molecular_function	25-hydroxycholecalciferol-23-hydroxylase activity
B	0062181	molecular_function	1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity
B	0070576	molecular_function	vitamin D 24-hydroxylase activity
B	0070643	molecular_function	vitamin D 25-hydroxylase activity
B	0071305	biological_process	cellular response to vitamin D

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM A 520

Chain	Residue
A	HOH4
A	SER334
A	THR394
A	ARG396
A	PRO454
A	PHE455
A	GLY456
A	ILE457
A	ARG460
A	MET461
A	CYS462
A	ARG128
A	GLY464
A	CPS600
A	LEU147
A	TRP155
A	ARG159
A	LEU323
A	ALA326
A	ALA327
A	THR330

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CPS A 600

Chain	Residue
A	SER205
A	ASN208
A	LYS243
A	GLU329
A	THR394
A	GLY499
A	HEM520
A	HOH584
A	HOH597
A	HOH618

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CPS A 601

Chain	Residue
A	GLN82
A	PHE104
A	LEU129
A	LYS132
A	MET253
B	LEU66

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CPS A 602

Chain	Residue
B	TRP64
B	GLU72

---

site_id	AC5
Number of Residues	20
Details	BINDING SITE FOR RESIDUE HEM B 520

Chain	Residue
B	ARG128
B	LEU147
B	TRP155
B	ARG159
B	LEU323
B	ALA326
B	ALA327
B	THR330
B	SER334
B	THR394
B	ARG396
B	PRO454
B	PHE455
B	GLY456
B	ILE457
B	ARG460
B	MET461
B	CYS462
B	GLY464
B	CPS700

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CPS B 700

Chain	Residue
B	TYR204
B	MET246
B	GLU329
B	PHE393
B	THR394
B	GLY499
B	HEM520
B	HOH599
B	HOH619

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CPS B 701

Chain	Residue
A	LEU66
B	PHE74
B	LEU79
B	PHE104
B	MET253
B	VAL254

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CPS B 702

Chain	Residue
A	TRP64
A	TRP75
B	ARG262

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Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGiGKRMCIG

Chain	Residue	Details
A	PHE455-GLY464

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0007744|PDB:3K9V, ECO:0007744|PDB:3K9Y

Chain	Residue	Details
A	CYS462
B	CYS462

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