3K7T
Crystal structure of apo-form 6-hydroxy-L-nicotine oxidase, crystal form P3121
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0018531 | molecular_function | (S)-6-hydroxynicotine oxidase activity |
| A | 0019608 | biological_process | nicotine catabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009820 | biological_process | alkaloid metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0018531 | molecular_function | (S)-6-hydroxynicotine oxidase activity |
| B | 0019608 | biological_process | nicotine catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE FAD A 434 |
| Chain | Residue |
| A | GLY8 |
| A | ARG39 |
| A | ALA40 |
| A | GLY56 |
| A | GLY57 |
| A | TYR59 |
| A | THR224 |
| A | VAL226 |
| A | ALA254 |
| A | THR255 |
| A | PRO256 |
| A | GLY10 |
| A | LEU366 |
| A | PHE367 |
| A | TRP371 |
| A | GLY397 |
| A | SER398 |
| A | GLY406 |
| A | TYR407 |
| A | ILE408 |
| A | ALA411 |
| A | PHE11 |
| A | SER12 |
| A | LEU30 |
| A | GLU31 |
| A | GLY32 |
| A | GLY37 |
| A | GLY38 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GP7 A 435 |
| Chain | Residue |
| A | GLN99 |
| A | ALA100 |
| A | THR115 |
| A | PHE159 |
| A | LEU160 |
| A | MET180 |
| A | ILE191 |
| A | LEU192 |
| A | VAL195 |
| B | ILE103 |
| B | GLY105 |
| B | ALA108 |
| site_id | AC3 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD B 434 |
| Chain | Residue |
| B | VAL7 |
| B | GLY8 |
| B | GLY10 |
| B | PHE11 |
| B | SER12 |
| B | LEU30 |
| B | GLU31 |
| B | GLY32 |
| B | GLY37 |
| B | GLY38 |
| B | ARG39 |
| B | GLY56 |
| B | GLY57 |
| B | TYR59 |
| B | THR224 |
| B | VAL225 |
| B | VAL226 |
| B | ALA254 |
| B | THR255 |
| B | PRO256 |
| B | ILE263 |
| B | TRP361 |
| B | LEU366 |
| B | PHE367 |
| B | PRO370 |
| B | GLY397 |
| B | SER398 |
| B | GLY406 |
| B | TYR407 |
| B | ILE408 |
| B | ALA411 |
| B | HOH519 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GP7 B 435 |
| Chain | Residue |
| A | ILE103 |
| A | PRO104 |
| A | GLY105 |
| B | ALA100 |
| B | VAL111 |
| B | THR115 |
| B | PHE159 |
| B | LEU160 |
| B | MET180 |
| B | ILE191 |
| B | LEU192 |
| B | VAL195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20006620, ECO:0000269|PubMed:21383134, ECO:0007744|PDB:3K7M, ECO:0007744|PDB:3K7Q, ECO:0007744|PDB:3K7T, ECO:0007744|PDB:3NG7, ECO:0007744|PDB:3NGC, ECO:0007744|PDB:3NH3, ECO:0007744|PDB:3NHO, ECO:0007744|PDB:3NK0, ECO:0007744|PDB:3NK1, ECO:0007744|PDB:3NK2, ECO:0007744|PDB:3NN0 |
| Chain | Residue | Details |
| A | SER12 | |
| B | GLY38 | |
| B | GLY56 | |
| B | VAL226 | |
| B | SER398 | |
| B | GLY406 | |
| A | GLU31 | |
| A | GLY38 | |
| A | GLY56 | |
| A | VAL226 | |
| A | SER398 | |
| A | GLY406 | |
| B | SER12 | |
| B | GLU31 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20006620, ECO:0000269|PubMed:21383134, ECO:0007744|PDB:3K7Q, ECO:0007744|PDB:3NG7, ECO:0007744|PDB:3NGC, ECO:0007744|PDB:3NH3 |
| Chain | Residue | Details |
| A | ASN166 | |
| A | TYR311 | |
| A | PHE326 | |
| A | TYR407 | |
| B | ASN166 | |
| B | TYR311 | |
| B | PHE326 | |
| B | TYR407 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20006620, ECO:0000269|PubMed:21383134, ECO:0007744|PDB:3NG7, ECO:0007744|PDB:3NGC, ECO:0007744|PDB:3NH3 |
| Chain | Residue | Details |
| A | TRP371 | |
| B | TRP371 |
