Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3K7R

Crystal structure of [TM][CuAtx1]3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006811	biological_process	monoatomic ion transport
A	0006825	biological_process	copper ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0016531	molecular_function	copper chaperone activity
A	0034599	biological_process	cellular response to oxidative stress
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006811	biological_process	monoatomic ion transport
B	0006825	biological_process	copper ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0016531	molecular_function	copper chaperone activity
B	0034599	biological_process	cellular response to oxidative stress
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006811	biological_process	monoatomic ion transport
C	0006825	biological_process	copper ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0016531	molecular_function	copper chaperone activity
C	0034599	biological_process	cellular response to oxidative stress
C	0046872	molecular_function	metal ion binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006811	biological_process	monoatomic ion transport
D	0006825	biological_process	copper ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0016531	molecular_function	copper chaperone activity
D	0034599	biological_process	cellular response to oxidative stress
D	0046872	molecular_function	metal ion binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006811	biological_process	monoatomic ion transport
E	0006825	biological_process	copper ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0016531	molecular_function	copper chaperone activity
E	0034599	biological_process	cellular response to oxidative stress
E	0046872	molecular_function	metal ion binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006811	biological_process	monoatomic ion transport
F	0006825	biological_process	copper ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0016531	molecular_function	copper chaperone activity
F	0034599	biological_process	cellular response to oxidative stress
F	0046872	molecular_function	metal ion binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006811	biological_process	monoatomic ion transport
G	0006825	biological_process	copper ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0016531	molecular_function	copper chaperone activity
G	0034599	biological_process	cellular response to oxidative stress
G	0046872	molecular_function	metal ion binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006811	biological_process	monoatomic ion transport
H	0006825	biological_process	copper ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0016531	molecular_function	copper chaperone activity
H	0034599	biological_process	cellular response to oxidative stress
H	0046872	molecular_function	metal ion binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006811	biological_process	monoatomic ion transport
I	0006825	biological_process	copper ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0016531	molecular_function	copper chaperone activity
I	0034599	biological_process	cellular response to oxidative stress
I	0046872	molecular_function	metal ion binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006811	biological_process	monoatomic ion transport
J	0006825	biological_process	copper ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0016531	molecular_function	copper chaperone activity
J	0034599	biological_process	cellular response to oxidative stress
J	0046872	molecular_function	metal ion binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006811	biological_process	monoatomic ion transport
K	0006825	biological_process	copper ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0016531	molecular_function	copper chaperone activity
K	0034599	biological_process	cellular response to oxidative stress
K	0046872	molecular_function	metal ion binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006811	biological_process	monoatomic ion transport
L	0006825	biological_process	copper ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0016531	molecular_function	copper chaperone activity
L	0034599	biological_process	cellular response to oxidative stress
L	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 74

Chain	Residue
A	CYS15
A	CYS18
A	CU75
C	4SM75

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CU A 75

Chain	Residue
C	CU74
C	4SM75
A	CYS15
A	CU74
B	CYS15
B	CU74
C	CYS15

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU B 74

Chain	Residue
A	CU75
B	CYS15
B	CYS18
C	4SM75

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU C 74

Chain	Residue
A	CU75
C	CYS15
C	CYS18
C	4SM75

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 4SM C 75

Chain	Residue
A	THR14
A	CYS15
A	CYS18
A	LYS65
A	CU74
A	CU75
B	THR14
B	CYS15
B	CYS18
B	LYS65
B	CU74
C	THR14
C	CYS18
C	LYS65
C	CU74

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU D 74

Chain	Residue
D	CYS15
D	CYS18
D	CU75
D	4SM76

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CU D 75

Chain	Residue
D	CYS15
D	CU74
D	4SM76
E	CYS15
E	CU74
F	CYS15
F	CU74

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 4SM D 76

Chain	Residue
D	THR14
D	CYS15
D	CYS18
D	CU74
D	CU75
E	THR14
E	CYS15
E	CYS18
E	LYS65
E	CU74
F	THR14
F	CYS18
F	LYS65
F	CU74

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLT D 77

Chain	Residue
A	CYS15
A	SER16
B	SER16
C	SER16
D	CYS15
D	SER16
D	GLY17
F	CYS15
F	SER16

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU E 74

Chain	Residue
D	CU75
D	4SM76
E	CYS15
E	CYS18

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU F 74

Chain	Residue
D	CU75
D	4SM76
F	CYS15
F	CYS18

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU G 74

Chain	Residue
G	CYS15
G	CYS18
G	CU75
I	4SM75

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CU G 75

Chain	Residue
G	CYS15
G	CU74
H	CYS15
H	CU74
I	CYS15
I	CU74
I	4SM75

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU H 74

Chain	Residue
G	CU75
H	CYS15
H	CYS18
I	4SM75

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU I 74

Chain	Residue
G	CU75
I	CYS15
I	CYS18
I	4SM75

site_id	BC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4SM I 75

Chain	Residue
H	THR14
H	CYS15
H	CYS18
H	CU74
I	THR14
I	LYS65
I	CU74
G	THR14
G	CYS18
G	CU74
G	CU75

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU J 74

Chain	Residue
J	CYS15
J	CYS18
J	CU75
J	4SM76

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU J 75

Chain	Residue
J	CYS15
J	CU74
K	CYS15
K	CU74
L	CYS15
L	CU74

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 4SM J 76

Chain	Residue
J	THR14
J	CYS18
J	LYS65
J	CU74
K	THR14
K	CYS18
K	LYS65
K	CU74
L	THR14
L	CYS15
L	CYS18
L	LYS65
L	CU74

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU K 74

Chain	Residue
J	CU75
J	4SM76
K	CYS15
K	CYS18

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU L 74

Chain	Residue
J	CU75
J	4SM76
L	CYS15
L	CYS18

site_id	CC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLT L 75

Chain	Residue
G	CYS15
G	SER16
H	SER16
I	SER16
J	CYS15
J	SER16
K	SER16
L	CYS15
L	SER16

Functional Information from PROSITE/UniProt

site_id	PS01047
Number of Residues	31
Details	HMA_1 Heavy-metal-associated domain. NvVMtCsGCsgaVNkvLtklepdvskidIsL

Chain	Residue	Details
A	ASN10-LEU40

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	768
Details	Domain: {"description":"HMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00280","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11327811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28865724","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3K7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)