3K7R
Crystal structure of [TM][CuAtx1]3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006825 | biological_process | copper ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0016531 | molecular_function | copper chaperone activity |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006825 | biological_process | copper ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0016531 | molecular_function | copper chaperone activity |
| B | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006825 | biological_process | copper ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0016531 | molecular_function | copper chaperone activity |
| C | 0034599 | biological_process | cellular response to oxidative stress |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006825 | biological_process | copper ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0016531 | molecular_function | copper chaperone activity |
| D | 0034599 | biological_process | cellular response to oxidative stress |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006825 | biological_process | copper ion transport |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0016531 | molecular_function | copper chaperone activity |
| E | 0034599 | biological_process | cellular response to oxidative stress |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006825 | biological_process | copper ion transport |
| F | 0006879 | biological_process | intracellular iron ion homeostasis |
| F | 0016531 | molecular_function | copper chaperone activity |
| F | 0034599 | biological_process | cellular response to oxidative stress |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006825 | biological_process | copper ion transport |
| G | 0006879 | biological_process | intracellular iron ion homeostasis |
| G | 0016531 | molecular_function | copper chaperone activity |
| G | 0034599 | biological_process | cellular response to oxidative stress |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006825 | biological_process | copper ion transport |
| H | 0006879 | biological_process | intracellular iron ion homeostasis |
| H | 0016531 | molecular_function | copper chaperone activity |
| H | 0034599 | biological_process | cellular response to oxidative stress |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005829 | cellular_component | cytosol |
| I | 0006825 | biological_process | copper ion transport |
| I | 0006879 | biological_process | intracellular iron ion homeostasis |
| I | 0016531 | molecular_function | copper chaperone activity |
| I | 0034599 | biological_process | cellular response to oxidative stress |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005829 | cellular_component | cytosol |
| J | 0006825 | biological_process | copper ion transport |
| J | 0006879 | biological_process | intracellular iron ion homeostasis |
| J | 0016531 | molecular_function | copper chaperone activity |
| J | 0034599 | biological_process | cellular response to oxidative stress |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0005829 | cellular_component | cytosol |
| K | 0006825 | biological_process | copper ion transport |
| K | 0006879 | biological_process | intracellular iron ion homeostasis |
| K | 0016531 | molecular_function | copper chaperone activity |
| K | 0034599 | biological_process | cellular response to oxidative stress |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0005829 | cellular_component | cytosol |
| L | 0006825 | biological_process | copper ion transport |
| L | 0006879 | biological_process | intracellular iron ion homeostasis |
| L | 0016531 | molecular_function | copper chaperone activity |
| L | 0034599 | biological_process | cellular response to oxidative stress |
| L | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU A 74 |
| Chain | Residue |
| A | CYS15 |
| A | CYS18 |
| A | CU75 |
| C | 4SM75 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CU A 75 |
| Chain | Residue |
| C | CU74 |
| C | 4SM75 |
| A | CYS15 |
| A | CU74 |
| B | CYS15 |
| B | CU74 |
| C | CYS15 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU B 74 |
| Chain | Residue |
| A | CU75 |
| B | CYS15 |
| B | CYS18 |
| C | 4SM75 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU C 74 |
| Chain | Residue |
| A | CU75 |
| C | CYS15 |
| C | CYS18 |
| C | 4SM75 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 4SM C 75 |
| Chain | Residue |
| A | THR14 |
| A | CYS15 |
| A | CYS18 |
| A | LYS65 |
| A | CU74 |
| A | CU75 |
| B | THR14 |
| B | CYS15 |
| B | CYS18 |
| B | LYS65 |
| B | CU74 |
| C | THR14 |
| C | CYS18 |
| C | LYS65 |
| C | CU74 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU D 74 |
| Chain | Residue |
| D | CYS15 |
| D | CYS18 |
| D | CU75 |
| D | 4SM76 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CU D 75 |
| Chain | Residue |
| D | CYS15 |
| D | CU74 |
| D | 4SM76 |
| E | CYS15 |
| E | CU74 |
| F | CYS15 |
| F | CU74 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 4SM D 76 |
| Chain | Residue |
| D | THR14 |
| D | CYS15 |
| D | CYS18 |
| D | CU74 |
| D | CU75 |
| E | THR14 |
| E | CYS15 |
| E | CYS18 |
| E | LYS65 |
| E | CU74 |
| F | THR14 |
| F | CYS18 |
| F | LYS65 |
| F | CU74 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MLT D 77 |
| Chain | Residue |
| A | CYS15 |
| A | SER16 |
| B | SER16 |
| C | SER16 |
| D | CYS15 |
| D | SER16 |
| D | GLY17 |
| F | CYS15 |
| F | SER16 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU E 74 |
| Chain | Residue |
| D | CU75 |
| D | 4SM76 |
| E | CYS15 |
| E | CYS18 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU F 74 |
| Chain | Residue |
| D | CU75 |
| D | 4SM76 |
| F | CYS15 |
| F | CYS18 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU G 74 |
| Chain | Residue |
| G | CYS15 |
| G | CYS18 |
| G | CU75 |
| I | 4SM75 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CU G 75 |
| Chain | Residue |
| G | CYS15 |
| G | CU74 |
| H | CYS15 |
| H | CU74 |
| I | CYS15 |
| I | CU74 |
| I | 4SM75 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU H 74 |
| Chain | Residue |
| G | CU75 |
| H | CYS15 |
| H | CYS18 |
| I | 4SM75 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU I 74 |
| Chain | Residue |
| G | CU75 |
| I | CYS15 |
| I | CYS18 |
| I | 4SM75 |
| site_id | BC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 4SM I 75 |
| Chain | Residue |
| H | THR14 |
| H | CYS15 |
| H | CYS18 |
| H | CU74 |
| I | THR14 |
| I | LYS65 |
| I | CU74 |
| G | THR14 |
| G | CYS18 |
| G | CU74 |
| G | CU75 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU J 74 |
| Chain | Residue |
| J | CYS15 |
| J | CYS18 |
| J | CU75 |
| J | 4SM76 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CU J 75 |
| Chain | Residue |
| J | CYS15 |
| J | CU74 |
| K | CYS15 |
| K | CU74 |
| L | CYS15 |
| L | CU74 |
| site_id | CC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 4SM J 76 |
| Chain | Residue |
| J | THR14 |
| J | CYS18 |
| J | LYS65 |
| J | CU74 |
| K | THR14 |
| K | CYS18 |
| K | LYS65 |
| K | CU74 |
| L | THR14 |
| L | CYS15 |
| L | CYS18 |
| L | LYS65 |
| L | CU74 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU K 74 |
| Chain | Residue |
| J | CU75 |
| J | 4SM76 |
| K | CYS15 |
| K | CYS18 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CU L 74 |
| Chain | Residue |
| J | CU75 |
| J | 4SM76 |
| L | CYS15 |
| L | CYS18 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MLT L 75 |
| Chain | Residue |
| G | CYS15 |
| G | SER16 |
| H | SER16 |
| I | SER16 |
| J | CYS15 |
| J | SER16 |
| K | SER16 |
| L | CYS15 |
| L | SER16 |
Functional Information from PROSITE/UniProt
| site_id | PS01047 |
| Number of Residues | 31 |
| Details | HMA_1 Heavy-metal-associated domain. NvVMtCsGCsgaVNkvLtklepdvskidIsL |
| Chain | Residue | Details |
| A | ASN10-LEU40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00280, ECO:0000269|PubMed:11327811, ECO:0000269|PubMed:19965379, ECO:0000269|PubMed:28865724, ECO:0007744|PDB:1FD8, ECO:0007744|PDB:3K7R, ECO:0007744|PDB:5VDE, ECO:0007744|PDB:5VDF |
| Chain | Residue | Details |
| A | CYS15 | |
| E | CYS18 | |
| F | CYS15 | |
| F | CYS18 | |
| G | CYS15 | |
| G | CYS18 | |
| H | CYS15 | |
| H | CYS18 | |
| I | CYS15 | |
| I | CYS18 | |
| J | CYS15 | |
| A | CYS18 | |
| J | CYS18 | |
| K | CYS15 | |
| K | CYS18 | |
| L | CYS15 | |
| L | CYS18 | |
| B | CYS15 | |
| B | CYS18 | |
| C | CYS15 | |
| C | CYS18 | |
| D | CYS15 | |
| D | CYS18 | |
| E | CYS15 |
