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3K6S

Structure of integrin alphaXbeta2 ectodomain

Functional Information from GO Data
ChainGOidnamespacecontents
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0008305cellular_componentintegrin complex
A0009887biological_processanimal organ morphogenesis
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010628biological_processpositive regulation of gene expression
A0016020cellular_componentmembrane
A0030335biological_processpositive regulation of cell migration
A0030667cellular_componentsecretory granule membrane
A0030971molecular_functionreceptor tyrosine kinase binding
A0031643biological_processpositive regulation of myelination
A0033627biological_processcell adhesion mediated by integrin
A0034113biological_processheterotypic cell-cell adhesion
A0034689cellular_componentintegrin alphaX-beta2 complex
A0038023molecular_functionsignaling receptor activity
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0051607biological_processdefense response to virus
A0070821cellular_componenttertiary granule membrane
A0098609biological_processcell-cell adhesion
A0101003cellular_componentficolin-1-rich granule membrane
A1905956biological_processpositive regulation of endothelial tube morphogenesis
B0001540molecular_functionamyloid-beta binding
B0001774biological_processmicroglial cell activation
B0001851molecular_functioncomplement component C3b binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006898biological_processreceptor-mediated endocytosis
B0006909biological_processphagocytosis
B0006911biological_processphagocytosis, engulfment
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0007155biological_processcell adhesion
B0007159biological_processleukocyte cell-cell adhesion
B0007160biological_processcell-matrix adhesion
B0007229biological_processintegrin-mediated signaling pathway
B0007267biological_processcell-cell signaling
B0008305cellular_componentintegrin complex
B0008360biological_processregulation of cell shape
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0019901molecular_functionprotein kinase binding
B0030369molecular_functionICAM-3 receptor activity
B0030593biological_processneutrophil chemotaxis
B0031072molecular_functionheat shock protein binding
B0031623biological_processreceptor internalization
B0032930biological_processpositive regulation of superoxide anion generation
B0033627biological_processcell adhesion mediated by integrin
B0034113biological_processheterotypic cell-cell adhesion
B0034687cellular_componentintegrin alphaL-beta2 complex
B0034688cellular_componentintegrin alphaM-beta2 complex
B0034689cellular_componentintegrin alphaX-beta2 complex
B0035579cellular_componentspecific granule membrane
B0035987biological_processendodermal cell differentiation
B0038024molecular_functioncargo receptor activity
B0043113biological_processreceptor clustering
B0043235cellular_componentreceptor complex
B0043315biological_processpositive regulation of neutrophil degranulation
B0044853cellular_componentplasma membrane raft
B0045121cellular_componentmembrane raft
B0045963biological_processnegative regulation of dopamine metabolic process
B0046872molecular_functionmetal ion binding
B0050730biological_processregulation of peptidyl-tyrosine phosphorylation
B0050839molecular_functioncell adhesion molecule binding
B0070062cellular_componentextracellular exosome
B0070821cellular_componenttertiary granule membrane
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0090314biological_processpositive regulation of protein targeting to membrane
B0097242biological_processamyloid-beta clearance
B0098609biological_processcell-cell adhesion
B0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
B0101003cellular_componentficolin-1-rich granule membrane
B1903561cellular_componentextracellular vesicle
B1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
B1990266biological_processneutrophil migration
B2000363biological_processpositive regulation of prostaglandin-E synthase activity
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007229biological_processintegrin-mediated signaling pathway
C0008284biological_processpositive regulation of cell population proliferation
C0008305cellular_componentintegrin complex
C0009887biological_processanimal organ morphogenesis
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010628biological_processpositive regulation of gene expression
C0016020cellular_componentmembrane
C0030335biological_processpositive regulation of cell migration
C0030667cellular_componentsecretory granule membrane
C0030971molecular_functionreceptor tyrosine kinase binding
C0031643biological_processpositive regulation of myelination
C0033627biological_processcell adhesion mediated by integrin
C0034113biological_processheterotypic cell-cell adhesion
C0034689cellular_componentintegrin alphaX-beta2 complex
C0038023molecular_functionsignaling receptor activity
C0045766biological_processpositive regulation of angiogenesis
C0046872molecular_functionmetal ion binding
C0051607biological_processdefense response to virus
C0070821cellular_componenttertiary granule membrane
C0098609biological_processcell-cell adhesion
C0101003cellular_componentficolin-1-rich granule membrane
C1905956biological_processpositive regulation of endothelial tube morphogenesis
D0001540molecular_functionamyloid-beta binding
D0001774biological_processmicroglial cell activation
D0001851molecular_functioncomplement component C3b binding
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006898biological_processreceptor-mediated endocytosis
D0006909biological_processphagocytosis
D0006911biological_processphagocytosis, engulfment
D0006915biological_processapoptotic process
D0006954biological_processinflammatory response
D0007155biological_processcell adhesion
D0007159biological_processleukocyte cell-cell adhesion
D0007160biological_processcell-matrix adhesion
D0007229biological_processintegrin-mediated signaling pathway
D0007267biological_processcell-cell signaling
D0008305cellular_componentintegrin complex
D0008360biological_processregulation of cell shape
D0009897cellular_componentexternal side of plasma membrane
D0009986cellular_componentcell surface
D0016020cellular_componentmembrane
D0016477biological_processcell migration
D0019901molecular_functionprotein kinase binding
D0030369molecular_functionICAM-3 receptor activity
D0030593biological_processneutrophil chemotaxis
D0031072molecular_functionheat shock protein binding
D0031623biological_processreceptor internalization
D0032930biological_processpositive regulation of superoxide anion generation
D0033627biological_processcell adhesion mediated by integrin
D0034113biological_processheterotypic cell-cell adhesion
D0034687cellular_componentintegrin alphaL-beta2 complex
D0034688cellular_componentintegrin alphaM-beta2 complex
D0034689cellular_componentintegrin alphaX-beta2 complex
D0035579cellular_componentspecific granule membrane
D0035987biological_processendodermal cell differentiation
D0038024molecular_functioncargo receptor activity
D0043113biological_processreceptor clustering
D0043235cellular_componentreceptor complex
D0043315biological_processpositive regulation of neutrophil degranulation
D0044853cellular_componentplasma membrane raft
D0045121cellular_componentmembrane raft
D0045963biological_processnegative regulation of dopamine metabolic process
D0046872molecular_functionmetal ion binding
D0050730biological_processregulation of peptidyl-tyrosine phosphorylation
D0050839molecular_functioncell adhesion molecule binding
D0070062cellular_componentextracellular exosome
D0070821cellular_componenttertiary granule membrane
D0071404biological_processcellular response to low-density lipoprotein particle stimulus
D0090314biological_processpositive regulation of protein targeting to membrane
D0097242biological_processamyloid-beta clearance
D0098609biological_processcell-cell adhesion
D0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
D0101003cellular_componentficolin-1-rich granule membrane
D1903561cellular_componentextracellular vesicle
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D1990266biological_processneutrophil migration
D2000363biological_processpositive regulation of prostaglandin-E synthase activity
E0005178molecular_functionintegrin binding
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0007155biological_processcell adhesion
E0007160biological_processcell-matrix adhesion
E0007229biological_processintegrin-mediated signaling pathway
E0008284biological_processpositive regulation of cell population proliferation
E0008305cellular_componentintegrin complex
E0009887biological_processanimal organ morphogenesis
E0009897cellular_componentexternal side of plasma membrane
E0009986cellular_componentcell surface
E0010628biological_processpositive regulation of gene expression
E0016020cellular_componentmembrane
E0030335biological_processpositive regulation of cell migration
E0030667cellular_componentsecretory granule membrane
E0030971molecular_functionreceptor tyrosine kinase binding
E0031643biological_processpositive regulation of myelination
E0033627biological_processcell adhesion mediated by integrin
E0034113biological_processheterotypic cell-cell adhesion
E0034689cellular_componentintegrin alphaX-beta2 complex
E0038023molecular_functionsignaling receptor activity
E0045766biological_processpositive regulation of angiogenesis
E0046872molecular_functionmetal ion binding
E0051607biological_processdefense response to virus
E0070821cellular_componenttertiary granule membrane
E0098609biological_processcell-cell adhesion
E0101003cellular_componentficolin-1-rich granule membrane
E1905956biological_processpositive regulation of endothelial tube morphogenesis
F0001540molecular_functionamyloid-beta binding
F0001774biological_processmicroglial cell activation
F0001851molecular_functioncomplement component C3b binding
F0005178molecular_functionintegrin binding
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006898biological_processreceptor-mediated endocytosis
F0006909biological_processphagocytosis
F0006911biological_processphagocytosis, engulfment
F0006915biological_processapoptotic process
F0006954biological_processinflammatory response
F0007155biological_processcell adhesion
F0007159biological_processleukocyte cell-cell adhesion
F0007160biological_processcell-matrix adhesion
F0007229biological_processintegrin-mediated signaling pathway
F0007267biological_processcell-cell signaling
F0008305cellular_componentintegrin complex
F0008360biological_processregulation of cell shape
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0016020cellular_componentmembrane
F0016477biological_processcell migration
F0019901molecular_functionprotein kinase binding
F0030369molecular_functionICAM-3 receptor activity
F0030593biological_processneutrophil chemotaxis
F0031072molecular_functionheat shock protein binding
F0031623biological_processreceptor internalization
F0032930biological_processpositive regulation of superoxide anion generation
F0033627biological_processcell adhesion mediated by integrin
F0034113biological_processheterotypic cell-cell adhesion
F0034687cellular_componentintegrin alphaL-beta2 complex
F0034688cellular_componentintegrin alphaM-beta2 complex
F0034689cellular_componentintegrin alphaX-beta2 complex
F0035579cellular_componentspecific granule membrane
F0035987biological_processendodermal cell differentiation
F0038024molecular_functioncargo receptor activity
F0043113biological_processreceptor clustering
F0043235cellular_componentreceptor complex
F0043315biological_processpositive regulation of neutrophil degranulation
F0044853cellular_componentplasma membrane raft
F0045121cellular_componentmembrane raft
F0045963biological_processnegative regulation of dopamine metabolic process
F0046872molecular_functionmetal ion binding
F0050730biological_processregulation of peptidyl-tyrosine phosphorylation
F0050839molecular_functioncell adhesion molecule binding
F0070062cellular_componentextracellular exosome
F0070821cellular_componenttertiary granule membrane
F0071404biological_processcellular response to low-density lipoprotein particle stimulus
F0090314biological_processpositive regulation of protein targeting to membrane
F0097242biological_processamyloid-beta clearance
F0098609biological_processcell-cell adhesion
F0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
F0101003cellular_componentficolin-1-rich granule membrane
F1903561cellular_componentextracellular vesicle
F1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
F1990266biological_processneutrophil migration
F2000363biological_processpositive regulation of prostaglandin-E synthase activity
G0005178molecular_functionintegrin binding
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0007155biological_processcell adhesion
G0007160biological_processcell-matrix adhesion
G0007229biological_processintegrin-mediated signaling pathway
G0008284biological_processpositive regulation of cell population proliferation
G0008305cellular_componentintegrin complex
G0009887biological_processanimal organ morphogenesis
G0009897cellular_componentexternal side of plasma membrane
G0009986cellular_componentcell surface
G0010628biological_processpositive regulation of gene expression
G0016020cellular_componentmembrane
G0030335biological_processpositive regulation of cell migration
G0030667cellular_componentsecretory granule membrane
G0030971molecular_functionreceptor tyrosine kinase binding
G0031643biological_processpositive regulation of myelination
G0033627biological_processcell adhesion mediated by integrin
G0034113biological_processheterotypic cell-cell adhesion
G0034689cellular_componentintegrin alphaX-beta2 complex
G0038023molecular_functionsignaling receptor activity
G0045766biological_processpositive regulation of angiogenesis
G0046872molecular_functionmetal ion binding
G0051607biological_processdefense response to virus
G0070821cellular_componenttertiary granule membrane
G0098609biological_processcell-cell adhesion
G0101003cellular_componentficolin-1-rich granule membrane
G1905956biological_processpositive regulation of endothelial tube morphogenesis
H0001540molecular_functionamyloid-beta binding
H0001774biological_processmicroglial cell activation
H0001851molecular_functioncomplement component C3b binding
H0005178molecular_functionintegrin binding
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0005925cellular_componentfocal adhesion
H0006898biological_processreceptor-mediated endocytosis
H0006909biological_processphagocytosis
H0006911biological_processphagocytosis, engulfment
H0006915biological_processapoptotic process
H0006954biological_processinflammatory response
H0007155biological_processcell adhesion
H0007159biological_processleukocyte cell-cell adhesion
H0007160biological_processcell-matrix adhesion
H0007229biological_processintegrin-mediated signaling pathway
H0007267biological_processcell-cell signaling
H0008305cellular_componentintegrin complex
H0008360biological_processregulation of cell shape
H0009897cellular_componentexternal side of plasma membrane
H0009986cellular_componentcell surface
H0016020cellular_componentmembrane
H0016477biological_processcell migration
H0019901molecular_functionprotein kinase binding
H0030369molecular_functionICAM-3 receptor activity
H0030593biological_processneutrophil chemotaxis
H0031072molecular_functionheat shock protein binding
H0031623biological_processreceptor internalization
H0032930biological_processpositive regulation of superoxide anion generation
H0033627biological_processcell adhesion mediated by integrin
H0034113biological_processheterotypic cell-cell adhesion
H0034687cellular_componentintegrin alphaL-beta2 complex
H0034688cellular_componentintegrin alphaM-beta2 complex
H0034689cellular_componentintegrin alphaX-beta2 complex
H0035579cellular_componentspecific granule membrane
H0035987biological_processendodermal cell differentiation
H0038024molecular_functioncargo receptor activity
H0043113biological_processreceptor clustering
H0043235cellular_componentreceptor complex
H0043315biological_processpositive regulation of neutrophil degranulation
H0044853cellular_componentplasma membrane raft
H0045121cellular_componentmembrane raft
H0045963biological_processnegative regulation of dopamine metabolic process
H0046872molecular_functionmetal ion binding
H0050730biological_processregulation of peptidyl-tyrosine phosphorylation
H0050839molecular_functioncell adhesion molecule binding
H0070062cellular_componentextracellular exosome
H0070821cellular_componenttertiary granule membrane
H0071404biological_processcellular response to low-density lipoprotein particle stimulus
H0090314biological_processpositive regulation of protein targeting to membrane
H0097242biological_processamyloid-beta clearance
H0098609biological_processcell-cell adhesion
H0098742biological_processcell-cell adhesion via plasma-membrane adhesion molecules
H0101003cellular_componentficolin-1-rich granule membrane
H1903561cellular_componentextracellular vesicle
H1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
H1990266biological_processneutrophil migration
H2000363biological_processpositive regulation of prostaglandin-E synthase activity
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCdtGyiGKnC
ChainResidueDetails
BCYS448-CYS459
BCYS540-CYS551

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsGl..GdCvCgqClC
ChainResidueDetails
BCYS484-CYS497
BCYS527-CYS542
BCYS568-CYS581

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCdtGYigknce..C
ChainResidueDetails
BCYS448-CYS461
BCYS540-CYS553
BCYS579-CYS593

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2708
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN1-ASP678
ESER140
ESER142
EASP240
GASP138
GSER140
GSER142
GASP240
DGLN1-ASP678
FGLN1-ASP678
HGLN1-ASP678
CASP138
CSER140
CSER142
CASP240
EASP138

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BSER114
HSER114
HSER116
HGLU212
CASP449
CASP451
CASP455
CASP511
CASN513
CASP515
CASP519
BSER116
CASP574
CASP578
CASP582
EASP447
EASP449
EASP451
EASP455
EASP511
EASN513
EASP515
BGLU212
EASP519
EASP574
EASP578
EASP582
GASP447
GASP449
GASP451
GASP455
GASP511
GASN513
DSER114
GASP515
GASP519
GASP574
GASP578
GASP582
DSER116
DGLU212
FSER114
FSER116
FGLU212

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72
ChainResidueDetails
BASP119
EASN373
EASN678
EASN716
GASN42
GASN373
GASN678
GASN716
DASP119
FASP119
HASP119
CASN42
CASN373
CASN678
CASN716
EASN42

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP120
GASN70
GASN920
GASN1031
DASP120
FASP120
HASP120
CASN920
CASN1031
EASN70
EASN920
EASN1031

site_idSWS_FT_FI5
Number of Residues16
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP151
FASN207
FASP209
FPRO211
HASP151
HASN207
HASP209
HPRO211
BASN207
BASP209
BPRO211
DASP151
DASN207
DASP209
DPRO211
FASP151

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASP242
DASP242
FASP242
HASP242

site_idSWS_FT_FI7
Number of Residues4
DetailsBINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:3K6S, ECO:0007744|PDB:3K71, ECO:0007744|PDB:3K72, ECO:0007744|PDB:4NEH
ChainResidueDetails
BGLU325
DGLU325
FGLU325
HGLU325

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:2954816
ChainResidueDetails
BGLN1
DGLN1
FGLN1
HGLN1

site_idSWS_FT_FI9
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN28
DASN28
FASN28
HASN28

site_idSWS_FT_FI10
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20033057, ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASN94
DASN94
FASN94
HASN94

site_idSWS_FT_FI11
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973
ChainResidueDetails
BASN190
DASN190
FASN190
HASN190

site_idSWS_FT_FI12
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN232
BASN479
DASN232
DASN479
FASN232
FASN479
HASN232
HASN479

site_idSWS_FT_FI13
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:24385486, ECO:0007744|PDB:4NEH, ECO:0007744|PDB:4NEN
ChainResidueDetails
BASN620
DASN620
FASN620
HASN620

218853

PDB entries from 2024-04-24

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