3K5I
Crystal structure of N5-carboxyaminoimidazole synthase from aspergillus clavatus in complex with ADP and 5-aminoimadazole ribonucleotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004638 | molecular_function | phosphoribosylaminoimidazole carboxylase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 384 |
| Chain | Residue |
| A | GLN211 |
| A | HOH460 |
| A | HOH461 |
| A | HOH504 |
| A | HOH558 |
| A | HOH706 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NHE A 385 |
| Chain | Residue |
| A | PHE158 |
| A | ARG159 |
| A | ASP213 |
| A | SER214 |
| A | HOH615 |
| A | GLY154 |
| A | ARG155 |
| A | ASN157 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP B 400 |
| Chain | Residue |
| B | LYS104 |
| B | LYS146 |
| B | ASN157 |
| B | GLU181 |
| B | LYS182 |
| B | TRP183 |
| B | ALA184 |
| B | PHE186 |
| B | GLU189 |
| B | GLN211 |
| B | GLU254 |
| B | CYS266 |
| B | GLU267 |
| B | HOH397 |
| B | HOH398 |
| B | MG401 |
| B | HOH563 |
| B | HOH584 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 401 |
| Chain | Residue |
| B | GLU254 |
| B | GLU267 |
| B | HOH397 |
| B | HOH398 |
| B | ADP400 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AIR B 402 |
| Chain | Residue |
| B | GLY13 |
| B | GLN14 |
| B | LEU15 |
| B | GLU73 |
| B | ARG271 |
| B | LYS345 |
| B | ARG352 |
| B | LYS353 |
| B | HOH528 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NHE C 384 |
| Chain | Residue |
| C | GLY154 |
| C | ARG155 |
| C | ASN157 |
| C | PHE158 |
| C | ARG159 |
| C | LEU173 |
| C | ASP213 |
| C | SER214 |
| C | HOH535 |
| site_id | AC7 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE ADP A 400 |
| Chain | Residue |
| A | LYS104 |
| A | LYS146 |
| A | ALA151 |
| A | TYR152 |
| A | ASP153 |
| A | GLY154 |
| A | ASN157 |
| A | GLU181 |
| A | LYS182 |
| A | TRP183 |
| A | ALA184 |
| A | PHE186 |
| A | GLU189 |
| A | GLN211 |
| A | SER214 |
| A | GLU254 |
| A | CYS266 |
| A | GLU267 |
| A | HOH392 |
| A | HOH393 |
| A | MG401 |
| A | HOH570 |
| A | HOH575 |
| A | HOH706 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | GLU254 |
| A | GLU267 |
| A | HOH392 |
| A | HOH393 |
| A | ADP400 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AIR A 402 |
| Chain | Residue |
| A | HOH573 |
| A | HOH599 |
| A | GLY13 |
| A | GLN14 |
| A | LEU15 |
| A | GLU73 |
| A | ILE74 |
| A | TYR152 |
| A | ASP153 |
| A | ARG155 |
| A | ARG271 |
| A | LYS345 |
| A | ARG352 |
| A | HOH395 |
| A | HOH414 |
| A | HOH556 |
| A | HOH557 |
| site_id | BC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE ADP C 400 |
| Chain | Residue |
| C | LYS104 |
| C | LYS146 |
| C | ALA151 |
| C | TYR152 |
| C | ASP153 |
| C | GLY154 |
| C | ASN157 |
| C | GLU181 |
| C | LYS182 |
| C | TRP183 |
| C | ALA184 |
| C | PHE186 |
| C | GLU189 |
| C | GLN211 |
| C | SER214 |
| C | GLU254 |
| C | CYS266 |
| C | GLU267 |
| C | HOH385 |
| C | HOH386 |
| C | HOH388 |
| C | MG401 |
| C | HOH525 |
| C | HOH540 |
| C | HOH629 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 401 |
| Chain | Residue |
| C | GLU254 |
| C | GLU267 |
| C | HOH385 |
| C | HOH386 |
| C | ADP400 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE AIR C 402 |
| Chain | Residue |
| C | GLY13 |
| C | GLN14 |
| C | LEU15 |
| C | GLU73 |
| C | TYR152 |
| C | ASP153 |
| C | ARG155 |
| C | ARG271 |
| C | LYS345 |
| C | ARG352 |
| C | HOH404 |
| C | HOH520 |
| C | HOH542 |
| C | HOH547 |
| C | HOH622 |
| C | HOH630 |
| site_id | BC4 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ADP D 400 |
| Chain | Residue |
| D | LYS104 |
| D | MET144 |
| D | LYS146 |
| D | ASN157 |
| D | GLU181 |
| D | LYS182 |
| D | TRP183 |
| D | ALA184 |
| D | PHE186 |
| D | GLU189 |
| D | GLU254 |
| D | CYS266 |
| D | GLU267 |
| D | HOH393 |
| D | HOH395 |
| D | MG401 |
| D | HOH510 |
| D | HOH520 |
| D | HOH543 |
| D | HOH619 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 401 |
| Chain | Residue |
| D | GLU254 |
| D | GLU267 |
| D | HOH393 |
| D | HOH395 |
| D | ADP400 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AIR D 402 |
| Chain | Residue |
| D | GLY13 |
| D | GLN14 |
| D | LEU15 |
| D | GLU73 |
| D | ILE74 |
| D | ARG271 |
| D | LYS345 |
| D | ARG352 |
| D | HOH490 |
| D | HOH499 |
