Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015204 | molecular_function | urea transmembrane transporter activity |
| A | 0015265 | molecular_function | urea channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0033219 | molecular_function | urea binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0071918 | biological_process | urea transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU A 338 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AU A 339 |
| Chain | Residue |
| A | CYS19 |
| A | THR31 |
| A | LEU35 |
| A | AU340 |
| A | AU341 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AU A 340 |
| Chain | Residue |
| A | AU341 |
| A | AU342 |
| A | CYS15 |
| A | CYS19 |
| A | AU339 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AU A 341 |
| Chain | Residue |
| A | CYS15 |
| A | ASP16 |
| A | AU339 |
| A | AU340 |
| A | AU342 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU A 342 |
| Chain | Residue |
| A | CYS15 |
| A | AU340 |
| A | AU341 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AU A 343 |
| Chain | Residue |
| A | THR47 |
| A | VAL50 |
| A | CYS51 |
| A | AU344 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE AU A 344 |
| Chain | Residue |
| A | THR47 |
| A | CYS51 |
| A | AU343 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU A 345 |
| Chain | Residue |
| A | CYS224 |
| A | AU346 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU A 346 |
| Chain | Residue |
| A | CYS224 |
| A | AU345 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MMU A 347 |
| Chain | Residue |
| A | GLU187 |
| A | VAL188 |
| A | PHE190 |
| A | PHE243 |
| A | HOH359 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MMU A 348 |
| Chain | Residue |
| A | GLN24 |
| A | VAL25 |
| A | PHE27 |
| A | LEU77 |
| A | PHE80 |
| A | LEU129 |
| A | THR130 |
| A | HOH370 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 55 |
| Details | INTRAMEM: Helical |
| Chain | Residue | Details |
| A | LEU11-MET26 | |
| A | THR31-TYR43 | |
| A | VAL172-MET189 | |
| A | ILE194-LEU205 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 163 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | THR47-LEU66 | |
| A | PRO71-PHE93 | |
| A | MET99-LEU121 | |
| A | VAL126-LYS146 | |
| A | ILE210-MET229 | |
| A | LEU238-TYR258 | |
| A | PHE264-LEU285 | |
| A | ILE288-GLY308 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | SER309-ARG337 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Important for channel permeability => ECO:0000250 |
| Chain | Residue | Details |
| A | THR294 | |
