3JZA

Crystal structure of human Rab1b in complex with the GEF domain of DrrA/SidM from Legionella pneumophila

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 365

Chain	Residue
A	GLY18
A	VAL19
A	GLY20
A	SER22

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. LLLiGDSGVGKscL

Chain	Residue	Details
A	LEU11-LEU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Region: {"description":"Switch 2 region; required for interaction with REP1/CHM"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"20064470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"20064470","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3JZA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I1O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23236136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HLQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27552051","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SZK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"(Microbial infection) O-(2-cholinephosphoryl)serine","evidences":[{"source":"PubMed","id":"21822290","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22158903","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22307087","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine","evidences":[{"source":"PubMed","id":"20651120","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	180
Details	Region: {"description":"Rab1 guanine nucleotide exchange factor"}

Chain

Residue

Details

---