3JZ6
Crystal structure of Mycobacterium smegmatis Branched Chain Aminotransferase in complex with pyridoxal-5'-phosphate at 1.9 angstrom.
Replaces: 3DTHFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
A | 0008483 | molecular_function | transaminase activity |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009081 | biological_process | branched-chain amino acid metabolic process |
A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0009098 | biological_process | L-leucine biosynthetic process |
A | 0009099 | biological_process | valine biosynthetic process |
A | 0018272 | biological_process | protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
A | 0052654 | molecular_function | L-leucine transaminase activity |
A | 0052655 | molecular_function | L-valine transaminase activity |
A | 0052656 | molecular_function | L-isoleucine transaminase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
B | 0008483 | molecular_function | transaminase activity |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009081 | biological_process | branched-chain amino acid metabolic process |
B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0009098 | biological_process | L-leucine biosynthetic process |
B | 0009099 | biological_process | valine biosynthetic process |
B | 0018272 | biological_process | protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
B | 0052654 | molecular_function | L-leucine transaminase activity |
B | 0052655 | molecular_function | L-valine transaminase activity |
B | 0052656 | molecular_function | L-isoleucine transaminase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE PLP A 369 |
Chain | Residue |
A | ARG101 |
A | ILE271 |
A | THR272 |
A | GLY313 |
A | THR314 |
A | GOL370 |
A | HOH382 |
A | HOH387 |
A | HOH396 |
A | HOH450 |
A | ARG194 |
A | LYS204 |
A | TYR209 |
A | GLU240 |
A | GLY243 |
A | ASN245 |
A | LEU268 |
A | GLY270 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE PLP B 369 |
Chain | Residue |
B | ARG101 |
B | ARG194 |
B | LYS204 |
B | TYR209 |
B | GLU240 |
B | GLY243 |
B | ASN245 |
B | LEU268 |
B | GLY270 |
B | ILE271 |
B | THR272 |
B | GLY313 |
B | THR314 |
B | GOL370 |
B | HOH373 |
B | HOH380 |
B | HOH432 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 370 |
Chain | Residue |
A | ARG194 |
A | ASN208 |
A | TYR209 |
A | SER212 |
A | TRP229 |
A | GLY242 |
A | GLY243 |
A | PLP369 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 370 |
Chain | Residue |
B | ARG194 |
B | ASN208 |
B | SER212 |
B | TRP229 |
B | GLY242 |
B | PLP369 |
B | HOH382 |
Functional Information from PROSITE/UniProt
site_id | PS00770 |
Number of Residues | 34 |
Details | AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EmGgmNLFfvfgsggsar..LvTpelsgsl.LpGItR |
Chain | Residue | Details |
A | GLU240-ARG273 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:20445230 |
Chain | Residue | Details |
A | ARG101 | |
A | TYR209 | |
A | THR314 | |
B | ARG101 | |
B | TYR209 | |
B | THR314 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | ILE271 | |
B | ILE271 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
Chain | Residue | Details |
A | LYS204 | |
B | LYS204 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) => ECO:0000269|PubMed:20094657 |
Chain | Residue | Details |
A | LYS299 | |
B | LYS299 |