3JZ6
Crystal structure of Mycobacterium smegmatis Branched Chain Aminotransferase in complex with pyridoxal-5'-phosphate at 1.9 angstrom.
Replaces: 3DTHFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009081 | biological_process | branched-chain amino acid metabolic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0009099 | biological_process | L-valine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018272 | biological_process | protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0052654 | molecular_function | L-leucine-2-oxoglutarate transaminase activity |
| A | 0052655 | molecular_function | L-valine-2-oxoglutarate transaminase activity |
| A | 0052656 | molecular_function | L-isoleucine-2-oxoglutarate transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004084 | molecular_function | branched-chain-amino-acid transaminase activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009081 | biological_process | branched-chain amino acid metabolic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018272 | biological_process | protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0052654 | molecular_function | L-leucine-2-oxoglutarate transaminase activity |
| B | 0052655 | molecular_function | L-valine-2-oxoglutarate transaminase activity |
| B | 0052656 | molecular_function | L-isoleucine-2-oxoglutarate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP A 369 |
| Chain | Residue |
| A | ARG101 |
| A | ILE271 |
| A | THR272 |
| A | GLY313 |
| A | THR314 |
| A | GOL370 |
| A | HOH382 |
| A | HOH387 |
| A | HOH396 |
| A | HOH450 |
| A | ARG194 |
| A | LYS204 |
| A | TYR209 |
| A | GLU240 |
| A | GLY243 |
| A | ASN245 |
| A | LEU268 |
| A | GLY270 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP B 369 |
| Chain | Residue |
| B | ARG101 |
| B | ARG194 |
| B | LYS204 |
| B | TYR209 |
| B | GLU240 |
| B | GLY243 |
| B | ASN245 |
| B | LEU268 |
| B | GLY270 |
| B | ILE271 |
| B | THR272 |
| B | GLY313 |
| B | THR314 |
| B | GOL370 |
| B | HOH373 |
| B | HOH380 |
| B | HOH432 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 370 |
| Chain | Residue |
| A | ARG194 |
| A | ASN208 |
| A | TYR209 |
| A | SER212 |
| A | TRP229 |
| A | GLY242 |
| A | GLY243 |
| A | PLP369 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 370 |
| Chain | Residue |
| B | ARG194 |
| B | ASN208 |
| B | SER212 |
| B | TRP229 |
| B | GLY242 |
| B | PLP369 |
| B | HOH382 |
Functional Information from PROSITE/UniProt
| site_id | PS00770 |
| Number of Residues | 34 |
| Details | AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EmGgmNLFfvfgsggsar..LvTpelsgsl.LpGItR |
| Chain | Residue | Details |
| A | GLU240-ARG273 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20445230","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)","evidences":[{"source":"PubMed","id":"20094657","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
