Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP A 207 |
| Chain | Residue |
| A | VAL7 |
| A | LYS46 |
| A | LYS46 |
| A | ASN47 |
| A | VAL63 |
| A | THR64 |
| A | ARG65 |
| A | HIS78 |
| A | PHE96 |
| A | GLY97 |
| A | GLY98 |
| A | ALA8 |
| A | ALA99 |
| A | GLN100 |
| A | ILE101 |
| A | LEU104 |
| A | THR125 |
| A | HOH165 |
| A | HOH203 |
| A | 5WA208 |
| A | ILE15 |
| A | GLY16 |
| A | ASN19 |
| A | ASN20 |
| A | LEU21 |
| A | GLY44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 5WA A 208 |
| Chain | Residue |
| A | MET6 |
| A | VAL7 |
| A | ALA8 |
| A | ASN20 |
| A | LEU21 |
| A | GLU28 |
| A | VAL32 |
| A | ASN47 |
| A | ILE51 |
| A | PHE96 |
| A | THR115 |
| A | NDP207 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP B 207 |
| Chain | Residue |
| B | VAL7 |
| B | ALA8 |
| B | ILE15 |
| B | GLY16 |
| B | ASN19 |
| B | ASN20 |
| B | LEU21 |
| B | GLY44 |
| B | ARG45 |
| B | LYS46 |
| B | LYS46 |
| B | ASN47 |
| B | VAL63 |
| B | THR64 |
| B | ARG65 |
| B | HIS78 |
| B | PHE96 |
| B | GLY97 |
| B | GLY98 |
| B | ALA99 |
| B | GLN100 |
| B | ILE101 |
| B | LEU104 |
| B | HOH164 |
| B | HOH179 |
| B | HOH189 |
| B | 5WA208 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 5WA B 208 |
| Chain | Residue |
| B | MET6 |
| B | VAL7 |
| B | ALA8 |
| B | GLU28 |
| B | VAL32 |
| B | ASN47 |
| B | ILE51 |
| B | PHE96 |
| B | THR115 |
| B | NDP207 |
| B | HOH219 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT |
| Chain | Residue | Details |
| A | VAL14-THR36 | |
