3JW8

Crystal structure of human mono-glyceride lipase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005515	molecular_function	protein binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006954	biological_process	inflammatory response
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019369	biological_process	arachidonate metabolic process
A	0019433	biological_process	triglyceride catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0046464	biological_process	acylglycerol catabolic process
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0050727	biological_process	regulation of inflammatory response
A	0051930	biological_process	regulation of sensory perception of pain
A	0052651	biological_process	monoacylglycerol catabolic process
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	2000124	biological_process	regulation of endocannabinoid signaling pathway
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005515	molecular_function	protein binding
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006954	biological_process	inflammatory response
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019369	biological_process	arachidonate metabolic process
B	0019433	biological_process	triglyceride catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0046464	biological_process	acylglycerol catabolic process
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0050727	biological_process	regulation of inflammatory response
B	0051930	biological_process	regulation of sensory perception of pain
B	0052651	biological_process	monoacylglycerol catabolic process
B	0052689	molecular_function	carboxylic ester hydrolase activity
B	2000124	biological_process	regulation of endocannabinoid signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 707

Chain	Residue
A	LEU158
A	ALA161
A	ASN162
A	SER165
A	ALA166
A	GLY220
A	MRD831
A	MRD886

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 831

Chain	Residue
A	HOH445
A	HOH513
A	MPD707
A	SER132

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MRD A 866

Chain	Residue
A	ALA61
A	HIS131
A	ILE189
A	LEU251
A	HIS279
A	VAL280
A	HOH445
A	HOH529

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 886

Chain	Residue
A	SER165
A	LYS170
A	LEU186
A	MPD707

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD B 812

Chain	Residue
B	ALA161
B	ASN162
B	SER165
B	LEU215
B	LEU223
B	HOH456
B	MRD830

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD B 830

Chain	Residue
B	SER132
B	HOH444
B	HOH516
B	MPD812

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MRD B 865

Chain	Residue
B	GLY60
B	ALA61
B	GLU63
B	HIS131
B	LEU194
B	TYR204
B	LEU251
B	HIS279
B	VAL280
B	HOH444
B	HOH447
B	HOH516

---

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VFLLGHSMGG

Chain	Residue	Details
A	VAL126-GLY135

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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