3JW8
Crystal structure of human mono-glyceride lipase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004622 | molecular_function | phosphatidylcholine lysophospholipase A1 activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0009966 | biological_process | regulation of signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0019369 | biological_process | arachidonate metabolic process |
| A | 0019433 | biological_process | triglyceride catabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046464 | biological_process | acylglycerol catabolic process |
| A | 0047372 | molecular_function | monoacylglycerol lipase activity |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051930 | biological_process | regulation of sensory perception of pain |
| A | 0052651 | biological_process | monoacylglycerol catabolic process |
| A | 2000124 | biological_process | regulation of endocannabinoid signaling pathway |
| B | 0004622 | molecular_function | phosphatidylcholine lysophospholipase A1 activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0009966 | biological_process | regulation of signal transduction |
| B | 0016020 | cellular_component | membrane |
| B | 0019369 | biological_process | arachidonate metabolic process |
| B | 0019433 | biological_process | triglyceride catabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046464 | biological_process | acylglycerol catabolic process |
| B | 0047372 | molecular_function | monoacylglycerol lipase activity |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 0051930 | biological_process | regulation of sensory perception of pain |
| B | 0052651 | biological_process | monoacylglycerol catabolic process |
| B | 2000124 | biological_process | regulation of endocannabinoid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD A 707 |
| Chain | Residue |
| A | LEU158 |
| A | ALA161 |
| A | ASN162 |
| A | SER165 |
| A | ALA166 |
| A | GLY220 |
| A | MRD831 |
| A | MRD886 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 831 |
| Chain | Residue |
| A | HOH445 |
| A | HOH513 |
| A | MPD707 |
| A | SER132 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MRD A 866 |
| Chain | Residue |
| A | ALA61 |
| A | HIS131 |
| A | ILE189 |
| A | LEU251 |
| A | HIS279 |
| A | VAL280 |
| A | HOH445 |
| A | HOH529 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 886 |
| Chain | Residue |
| A | SER165 |
| A | LYS170 |
| A | LEU186 |
| A | MPD707 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD B 812 |
| Chain | Residue |
| B | ALA161 |
| B | ASN162 |
| B | SER165 |
| B | LEU215 |
| B | LEU223 |
| B | HOH456 |
| B | MRD830 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD B 830 |
| Chain | Residue |
| B | SER132 |
| B | HOH444 |
| B | HOH516 |
| B | MPD812 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MRD B 865 |
| Chain | Residue |
| B | GLY60 |
| B | ALA61 |
| B | GLU63 |
| B | HIS131 |
| B | LEU194 |
| B | TYR204 |
| B | LEU251 |
| B | HIS279 |
| B | VAL280 |
| B | HOH444 |
| B | HOH447 |
| B | HOH516 |
Functional Information from PROSITE/UniProt
| site_id | PS00120 |
| Number of Residues | 10 |
| Details | LIPASE_SER Lipases, serine active site. VFLLGHSMGG |
| Chain | Residue | Details |
| A | VAL126-GLY135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19957260","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"O35678","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
