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3JW8

Crystal structure of human mono-glyceride lipase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004622molecular_functionlysophospholipase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006633biological_processfatty acid biosynthetic process
A0006639biological_processacylglycerol metabolic process
A0006954biological_processinflammatory response
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0019369biological_processarachidonic acid metabolic process
A0019433biological_processtriglyceride catabolic process
A0042803molecular_functionprotein homodimerization activity
A0046464biological_processacylglycerol catabolic process
A0047372molecular_functionacylglycerol lipase activity
A0050727biological_processregulation of inflammatory response
A0051930biological_processregulation of sensory perception of pain
A0052651biological_processmonoacylglycerol catabolic process
A0052689molecular_functioncarboxylic ester hydrolase activity
A2000124biological_processregulation of endocannabinoid signaling pathway
B0004622molecular_functionlysophospholipase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006633biological_processfatty acid biosynthetic process
B0006639biological_processacylglycerol metabolic process
B0006954biological_processinflammatory response
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0019369biological_processarachidonic acid metabolic process
B0019433biological_processtriglyceride catabolic process
B0042803molecular_functionprotein homodimerization activity
B0046464biological_processacylglycerol catabolic process
B0047372molecular_functionacylglycerol lipase activity
B0050727biological_processregulation of inflammatory response
B0051930biological_processregulation of sensory perception of pain
B0052651biological_processmonoacylglycerol catabolic process
B0052689molecular_functioncarboxylic ester hydrolase activity
B2000124biological_processregulation of endocannabinoid signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MPD A 707
ChainResidue
ALEU158
AALA161
AASN162
ASER165
AALA166
AGLY220
AMRD831
AMRD886

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MRD A 831
ChainResidue
AHOH445
AHOH513
AMPD707
ASER132

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MRD A 866
ChainResidue
AALA61
AHIS131
AILE189
ALEU251
AHIS279
AVAL280
AHOH445
AHOH529

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MRD A 886
ChainResidue
ASER165
ALYS170
ALEU186
AMPD707

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MPD B 812
ChainResidue
BALA161
BASN162
BSER165
BLEU215
BLEU223
BHOH456
BMRD830

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MRD B 830
ChainResidue
BSER132
BHOH444
BHOH516
BMPD812

site_idAC7
Number of Residues12
DetailsBINDING SITE FOR RESIDUE MRD B 865
ChainResidue
BGLY60
BALA61
BGLU63
BHIS131
BLEU194
BTYR204
BLEU251
BHIS279
BVAL280
BHOH444
BHOH447
BHOH516

Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. VFLLGHSMGG
ChainResidueDetails
AVAL126-GLY135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:19957260
ChainResidueDetails
APRO122
BPRO122

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Charge relay system => ECO:0000305|PubMed:19957260
ChainResidueDetails
AVAL239
ALYS269
BVAL239
BLYS269

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ASER10
BSER10

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:O35678
ChainResidueDetails
ASER58
BSER58

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PDB entries from 2024-09-04

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