3JSP

Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006508	biological_process	proteolysis
A	0006974	biological_process	DNA damage response
A	0009432	biological_process	SOS response
A	0016787	molecular_function	hydrolase activity
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006281	biological_process	DNA repair
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006508	biological_process	proteolysis
B	0006974	biological_process	DNA damage response
B	0009432	biological_process	SOS response
B	0016787	molecular_function	hydrolase activity
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	DNA_BIND: H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00015

Chain	Residue	Details
A	ARG28-LYS48
B	ARG28-LYS48

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For autocatalytic cleavage activity => ECO:0000255|HAMAP-Rule:MF_00015

Chain	Residue	Details
A	SER119
A	ALA156
B	SER119
B	ALA156

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Cleavage; by autolysis

Chain	Residue	Details
A	ALA84
B	ALA84

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 724

Chain	Residue	Details
A	MET118	electrostatic stabiliser
A	SER119	electrostatic stabiliser
A	GLU152	electrostatic stabiliser
A	ALA156	proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 724

Chain	Residue	Details
B	MET118	electrostatic stabiliser
B	SER119	electrostatic stabiliser
B	GLU152	electrostatic stabiliser
B	ALA156	proton acceptor, proton donor

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