3JCT

Cryo-em structure of eukaryotic pre-60S ribosomal subunits

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
4	0000055	biological_process	ribosomal large subunit export from nucleus
4	0003674	molecular_function	molecular_function
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005730	cellular_component	nucleolus
4	0005737	cellular_component	cytoplasm
4	0006508	biological_process	proteolysis
4	0008237	molecular_function	metallopeptidase activity
4	0030687	cellular_component	preribosome, large subunit precursor
4	0046872	molecular_function	metal ion binding
5	0003674	molecular_function	molecular_function
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005730	cellular_component	nucleolus
5	0006364	biological_process	rRNA processing
5	0030687	cellular_component	preribosome, large subunit precursor
5	0042254	biological_process	ribosome biogenesis
A	0002181	biological_process	cytoplasmic translation
A	0003723	molecular_function	RNA binding
A	0003735	molecular_function	structural constituent of ribosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005840	cellular_component	ribosome
A	0006412	biological_process	translation
A	0019843	molecular_function	rRNA binding
A	0022625	cellular_component	cytosolic large ribosomal subunit
A	0022626	cellular_component	cytosolic ribosome
A	0042273	biological_process	ribosomal large subunit biogenesis
A	1990145	biological_process	maintenance of translational fidelity
A	1990904	cellular_component	ribonucleoprotein complex
B	0000027	biological_process	ribosomal large subunit assembly
B	0002181	biological_process	cytoplasmic translation
B	0003723	molecular_function	RNA binding
B	0003735	molecular_function	structural constituent of ribosome
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005840	cellular_component	ribosome
B	0006364	biological_process	rRNA processing
B	0006412	biological_process	translation
B	0006414	biological_process	translational elongation
B	0022625	cellular_component	cytosolic large ribosomal subunit
B	1990145	biological_process	maintenance of translational fidelity
B	1990904	cellular_component	ribonucleoprotein complex
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005840	cellular_component	ribosome
C	0006412	biological_process	translation
C	0022625	cellular_component	cytosolic large ribosomal subunit
C	1990904	cellular_component	ribonucleoprotein complex
D	0000027	biological_process	ribosomal large subunit assembly
D	0002181	biological_process	cytoplasmic translation
D	0003735	molecular_function	structural constituent of ribosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0008097	molecular_function	5S rRNA binding
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0000027	biological_process	ribosomal large subunit assembly
E	0002181	biological_process	cytoplasmic translation
E	0003723	molecular_function	RNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006412	biological_process	translation
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	1990904	cellular_component	ribonucleoprotein complex
F	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F	0000470	biological_process	maturation of LSU-rRNA
F	0002181	biological_process	cytoplasmic translation
F	0003723	molecular_function	RNA binding
F	0003735	molecular_function	structural constituent of ribosome
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005840	cellular_component	ribosome
F	0022625	cellular_component	cytosolic large ribosomal subunit
F	0042273	biological_process	ribosomal large subunit biogenesis
F	1990904	cellular_component	ribonucleoprotein complex
G	0000470	biological_process	maturation of LSU-rRNA
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0006364	biological_process	rRNA processing
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	0042254	biological_process	ribosome biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0002181	biological_process	cytoplasmic translation
H	0003735	molecular_function	structural constituent of ribosome
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0006412	biological_process	translation
H	0019843	molecular_function	rRNA binding
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	1990904	cellular_component	ribonucleoprotein complex
I	0000055	biological_process	ribosomal large subunit export from nucleus
I	0003676	molecular_function	nucleic acid binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0008270	molecular_function	zinc ion binding
I	0030687	cellular_component	preribosome, large subunit precursor
I	0042254	biological_process	ribosome biogenesis
I	0043023	molecular_function	ribosomal large subunit binding
I	0046872	molecular_function	metal ion binding
J	0000027	biological_process	ribosomal large subunit assembly
J	0002181	biological_process	cytoplasmic translation
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	1990904	cellular_component	ribonucleoprotein complex
K	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K	0000502	cellular_component	proteasome complex
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005730	cellular_component	nucleolus
K	0019843	molecular_function	rRNA binding
K	0030163	biological_process	protein catabolic process
K	0030674	molecular_function	protein-macromolecule adaptor activity
K	0030687	cellular_component	preribosome, large subunit precursor
K	0042254	biological_process	ribosome biogenesis
K	0042802	molecular_function	identical protein binding
K	0070180	molecular_function	large ribosomal subunit rRNA binding
K	0070628	molecular_function	proteasome binding
K	1990904	cellular_component	ribonucleoprotein complex
L	0002181	biological_process	cytoplasmic translation
L	0003723	molecular_function	RNA binding
L	0003735	molecular_function	structural constituent of ribosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0006412	biological_process	translation
L	0022625	cellular_component	cytosolic large ribosomal subunit
L	1990904	cellular_component	ribonucleoprotein complex
M	0000027	biological_process	ribosomal large subunit assembly
M	0000470	biological_process	maturation of LSU-rRNA
M	0002181	biological_process	cytoplasmic translation
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0006412	biological_process	translation
M	0016236	biological_process	macroautophagy
M	0022625	cellular_component	cytosolic large ribosomal subunit
M	0032991	cellular_component	protein-containing complex
M	0042273	biological_process	ribosomal large subunit biogenesis
M	0043232	cellular_component	intracellular non-membrane-bounded organelle
M	1990904	cellular_component	ribonucleoprotein complex
N	0002181	biological_process	cytoplasmic translation
N	0003723	molecular_function	RNA binding
N	0003735	molecular_function	structural constituent of ribosome
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	0022626	cellular_component	cytosolic ribosome
N	1990904	cellular_component	ribonucleoprotein complex
O	0000470	biological_process	maturation of LSU-rRNA
O	0002181	biological_process	cytoplasmic translation
O	0003723	molecular_function	RNA binding
O	0003729	molecular_function	mRNA binding
O	0003735	molecular_function	structural constituent of ribosome
O	0005730	cellular_component	nucleolus
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0006412	biological_process	translation
O	0015934	cellular_component	large ribosomal subunit
O	0017148	biological_process	negative regulation of translation
O	0022625	cellular_component	cytosolic large ribosomal subunit
O	1990904	cellular_component	ribonucleoprotein complex
P	0000448	biological_process	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
P	0002181	biological_process	cytoplasmic translation
P	0003735	molecular_function	structural constituent of ribosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0015934	cellular_component	large ribosomal subunit
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	0030687	cellular_component	preribosome, large subunit precursor
P	1990904	cellular_component	ribonucleoprotein complex
Q	0002181	biological_process	cytoplasmic translation
Q	0003723	molecular_function	RNA binding
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0006412	biological_process	translation
Q	0022625	cellular_component	cytosolic large ribosomal subunit
Q	0043232	cellular_component	intracellular non-membrane-bounded organelle
Q	1990904	cellular_component	ribonucleoprotein complex
R	0002181	biological_process	cytoplasmic translation
R	0003723	molecular_function	RNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0006412	biological_process	translation
R	0022625	cellular_component	cytosolic large ribosomal subunit
R	1990904	cellular_component	ribonucleoprotein complex
S	0002181	biological_process	cytoplasmic translation
S	0003735	molecular_function	structural constituent of ribosome
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	1990904	cellular_component	ribonucleoprotein complex
T	0002181	biological_process	cytoplasmic translation
T	0003735	molecular_function	structural constituent of ribosome
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0002181	biological_process	cytoplasmic translation
U	0003723	molecular_function	RNA binding
U	0003735	molecular_function	structural constituent of ribosome
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0022625	cellular_component	cytosolic large ribosomal subunit
U	1990904	cellular_component	ribonucleoprotein complex
V	0002181	biological_process	cytoplasmic translation
V	0003735	molecular_function	structural constituent of ribosome
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005840	cellular_component	ribosome
V	0006412	biological_process	translation
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	0070180	molecular_function	large ribosomal subunit rRNA binding
V	1990904	cellular_component	ribonucleoprotein complex
W	0000027	biological_process	ribosomal large subunit assembly
W	0000055	biological_process	ribosomal large subunit export from nucleus
W	0000956	biological_process	nuclear-transcribed mRNA catabolic process
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005730	cellular_component	nucleolus
W	0005737	cellular_component	cytoplasm
W	0006364	biological_process	rRNA processing
W	0030490	biological_process	maturation of SSU-rRNA
W	0030687	cellular_component	preribosome, large subunit precursor
W	0032040	cellular_component	small-subunit processome
W	0042254	biological_process	ribosome biogenesis
W	0042273	biological_process	ribosomal large subunit biogenesis
W	0070180	molecular_function	large ribosomal subunit rRNA binding
X	0000027	biological_process	ribosomal large subunit assembly
X	0002181	biological_process	cytoplasmic translation
X	0003723	molecular_function	RNA binding
X	0003735	molecular_function	structural constituent of ribosome
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005840	cellular_component	ribosome
X	0006412	biological_process	translation
X	0019843	molecular_function	rRNA binding
X	0022625	cellular_component	cytosolic large ribosomal subunit
X	0030687	cellular_component	preribosome, large subunit precursor
X	1990904	cellular_component	ribonucleoprotein complex
Y	0002181	biological_process	cytoplasmic translation
Y	0003723	molecular_function	RNA binding
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005737	cellular_component	cytoplasm
Y	0005829	cellular_component	cytosol
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0015934	cellular_component	large ribosomal subunit
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	0032991	cellular_component	protein-containing complex
Y	0042273	biological_process	ribosomal large subunit biogenesis
Y	0043232	cellular_component	intracellular non-membrane-bounded organelle
Y	1990904	cellular_component	ribonucleoprotein complex
Z	0002181	biological_process	cytoplasmic translation
Z	0003735	molecular_function	structural constituent of ribosome
Z	0005737	cellular_component	cytoplasm
Z	0005829	cellular_component	cytosol
Z	0005840	cellular_component	ribosome
Z	0006412	biological_process	translation
Z	0022625	cellular_component	cytosolic large ribosomal subunit
Z	1990904	cellular_component	ribonucleoprotein complex
a	0002181	biological_process	cytoplasmic translation
a	0003723	molecular_function	RNA binding
a	0003735	molecular_function	structural constituent of ribosome
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005840	cellular_component	ribosome
a	0006412	biological_process	translation
a	0015934	cellular_component	large ribosomal subunit
a	0022625	cellular_component	cytosolic large ribosomal subunit
a	0043232	cellular_component	intracellular non-membrane-bounded organelle
a	1990904	cellular_component	ribonucleoprotein complex
b	0000054	biological_process	ribosomal subunit export from nucleus
b	0003723	molecular_function	RNA binding
b	0003924	molecular_function	GTPase activity
b	0005515	molecular_function	protein binding
b	0005525	molecular_function	GTP binding
b	0005634	cellular_component	nucleus
b	0005730	cellular_component	nucleolus
b	0005737	cellular_component	cytoplasm
b	0006364	biological_process	rRNA processing
b	0030687	cellular_component	preribosome, large subunit precursor
b	0042254	biological_process	ribosome biogenesis
b	0042273	biological_process	ribosomal large subunit biogenesis
b	1902626	biological_process	assembly of large subunit precursor of preribosome
c	0002181	biological_process	cytoplasmic translation
c	0003723	molecular_function	RNA binding
c	0003735	molecular_function	structural constituent of ribosome
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005840	cellular_component	ribosome
c	0006364	biological_process	rRNA processing
c	0022625	cellular_component	cytosolic large ribosomal subunit
c	0030627	molecular_function	pre-mRNA 5'-splice site binding
c	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
c	1990904	cellular_component	ribonucleoprotein complex
d	0002181	biological_process	cytoplasmic translation
d	0003735	molecular_function	structural constituent of ribosome
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005840	cellular_component	ribosome
d	0006412	biological_process	translation
d	0006450	biological_process	regulation of translational fidelity
d	0022625	cellular_component	cytosolic large ribosomal subunit
d	1990904	cellular_component	ribonucleoprotein complex
e	0002181	biological_process	cytoplasmic translation
e	0003735	molecular_function	structural constituent of ribosome
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005840	cellular_component	ribosome
e	0006412	biological_process	translation
e	0022625	cellular_component	cytosolic large ribosomal subunit
e	1990904	cellular_component	ribonucleoprotein complex
f	0000027	biological_process	ribosomal large subunit assembly
f	0002181	biological_process	cytoplasmic translation
f	0003735	molecular_function	structural constituent of ribosome
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005840	cellular_component	ribosome
f	0006364	biological_process	rRNA processing
f	0006412	biological_process	translation
f	0022625	cellular_component	cytosolic large ribosomal subunit
f	0042273	biological_process	ribosomal large subunit biogenesis
f	1990904	cellular_component	ribonucleoprotein complex
g	0002181	biological_process	cytoplasmic translation
g	0003735	molecular_function	structural constituent of ribosome
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005840	cellular_component	ribosome
g	0006412	biological_process	translation
g	0022625	cellular_component	cytosolic large ribosomal subunit
g	0030687	cellular_component	preribosome, large subunit precursor
g	0042254	biological_process	ribosome biogenesis
g	1990904	cellular_component	ribonucleoprotein complex
h	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
h	0002181	biological_process	cytoplasmic translation
h	0003729	molecular_function	mRNA binding
h	0003735	molecular_function	structural constituent of ribosome
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005840	cellular_component	ribosome
h	0006412	biological_process	translation
h	0022625	cellular_component	cytosolic large ribosomal subunit
h	0030687	cellular_component	preribosome, large subunit precursor
h	1990904	cellular_component	ribonucleoprotein complex
i	0002181	biological_process	cytoplasmic translation
i	0003723	molecular_function	RNA binding
i	0003735	molecular_function	structural constituent of ribosome
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0005840	cellular_component	ribosome
i	0006412	biological_process	translation
i	0022625	cellular_component	cytosolic large ribosomal subunit
i	1990904	cellular_component	ribonucleoprotein complex
j	0000448	biological_process	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
j	0002181	biological_process	cytoplasmic translation
j	0003723	molecular_function	RNA binding
j	0003735	molecular_function	structural constituent of ribosome
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005840	cellular_component	ribosome
j	0006412	biological_process	translation
j	0008270	molecular_function	zinc ion binding
j	0019843	molecular_function	rRNA binding
j	0022625	cellular_component	cytosolic large ribosomal subunit
j	0030687	cellular_component	preribosome, large subunit precursor
j	0044391	cellular_component	ribosomal subunit
j	0046872	molecular_function	metal ion binding
j	1990904	cellular_component	ribonucleoprotein complex
k	0002181	biological_process	cytoplasmic translation
k	0003735	molecular_function	structural constituent of ribosome
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005840	cellular_component	ribosome
k	0006412	biological_process	translation
k	0022618	biological_process	protein-RNA complex assembly
k	0022625	cellular_component	cytosolic large ribosomal subunit
k	1990904	cellular_component	ribonucleoprotein complex
l	0002181	biological_process	cytoplasmic translation
l	0003735	molecular_function	structural constituent of ribosome
l	0005515	molecular_function	protein binding
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005840	cellular_component	ribosome
l	0006412	biological_process	translation
l	0022625	cellular_component	cytosolic large ribosomal subunit
l	1990904	cellular_component	ribonucleoprotein complex
m	0000055	biological_process	ribosomal large subunit export from nucleus
m	0003924	molecular_function	GTPase activity
m	0005515	molecular_function	protein binding
m	0005525	molecular_function	GTP binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005730	cellular_component	nucleolus
m	0030687	cellular_component	preribosome, large subunit precursor
m	0042254	biological_process	ribosome biogenesis
m	0070180	molecular_function	large ribosomal subunit rRNA binding
m	2000200	biological_process	regulation of ribosomal subunit export from nucleus
n	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
n	0003723	molecular_function	RNA binding
n	0003729	molecular_function	mRNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005730	cellular_component	nucleolus
n	0006364	biological_process	rRNA processing
n	0030687	cellular_component	preribosome, large subunit precursor
n	0042254	biological_process	ribosome biogenesis
n	0042273	biological_process	ribosomal large subunit biogenesis
n	0043021	molecular_function	ribonucleoprotein complex binding
n	0070180	molecular_function	large ribosomal subunit rRNA binding
n	0070545	cellular_component	PeBoW complex
o	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
o	0003674	molecular_function	molecular_function
o	0003676	molecular_function	nucleic acid binding
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005730	cellular_component	nucleolus
o	0005737	cellular_component	cytoplasm
o	0006364	biological_process	rRNA processing
o	0019843	molecular_function	rRNA binding
o	0030687	cellular_component	preribosome, large subunit precursor
o	0042254	biological_process	ribosome biogenesis
o	0042273	biological_process	ribosomal large subunit biogenesis
o	1990904	cellular_component	ribonucleoprotein complex
p	0002181	biological_process	cytoplasmic translation
p	0003735	molecular_function	structural constituent of ribosome
p	0005737	cellular_component	cytoplasm
p	0005829	cellular_component	cytosol
p	0005840	cellular_component	ribosome
p	0006412	biological_process	translation
p	0022625	cellular_component	cytosolic large ribosomal subunit
p	0044391	cellular_component	ribosomal subunit
p	0046872	molecular_function	metal ion binding
p	0070180	molecular_function	large ribosomal subunit rRNA binding
p	1990904	cellular_component	ribonucleoprotein complex
q	0000027	biological_process	ribosomal large subunit assembly
q	0000055	biological_process	ribosomal large subunit export from nucleus
q	0000176	cellular_component	nuclear exosome (RNase complex)
q	0000460	biological_process	maturation of 5.8S rRNA
q	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
q	0003723	molecular_function	RNA binding
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005730	cellular_component	nucleolus
q	0006364	biological_process	rRNA processing
q	0008097	molecular_function	5S rRNA binding
q	0019843	molecular_function	rRNA binding
q	0042254	biological_process	ribosome biogenesis
r	0000460	biological_process	maturation of 5.8S rRNA
r	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
r	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
r	0000470	biological_process	maturation of LSU-rRNA
r	0003674	molecular_function	molecular_function
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005730	cellular_component	nucleolus
r	0006364	biological_process	rRNA processing
r	0030687	cellular_component	preribosome, large subunit precursor
r	0042254	biological_process	ribosome biogenesis
r	0042273	biological_process	ribosomal large subunit biogenesis
s	0000055	biological_process	ribosomal large subunit export from nucleus
s	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
s	0003723	molecular_function	RNA binding
s	0003729	molecular_function	mRNA binding
s	0003924	molecular_function	GTPase activity
s	0005515	molecular_function	protein binding
s	0005525	molecular_function	GTP binding
s	0005634	cellular_component	nucleus
s	0005730	cellular_component	nucleolus
s	0015031	biological_process	protein transport
s	0030687	cellular_component	preribosome, large subunit precursor
s	0042254	biological_process	ribosome biogenesis
t	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
t	0000465	biological_process	exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
t	0003723	molecular_function	RNA binding
t	0003729	molecular_function	mRNA binding
t	0003735	molecular_function	structural constituent of ribosome
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005730	cellular_component	nucleolus
t	0022625	cellular_component	cytosolic large ribosomal subunit
t	0030687	cellular_component	preribosome, large subunit precursor
t	0042134	molecular_function	rRNA primary transcript binding
t	0042254	biological_process	ribosome biogenesis
t	0042273	biological_process	ribosomal large subunit biogenesis
u	0001671	molecular_function	ATPase activator activity
u	0005634	cellular_component	nucleus
u	0005730	cellular_component	nucleolus
u	0005737	cellular_component	cytoplasm
u	0030687	cellular_component	preribosome, large subunit precursor
u	0032781	biological_process	positive regulation of ATP-dependent activity
u	0042254	biological_process	ribosome biogenesis
u	0042273	biological_process	ribosomal large subunit biogenesis
u	0051117	molecular_function	ATPase binding
u	1902626	biological_process	assembly of large subunit precursor of preribosome
v	0000027	biological_process	ribosomal large subunit assembly
v	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
v	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
v	0000470	biological_process	maturation of LSU-rRNA
v	0005515	molecular_function	protein binding
v	0005634	cellular_component	nucleus
v	0005730	cellular_component	nucleolus
v	0006364	biological_process	rRNA processing
v	0008097	molecular_function	5S rRNA binding
v	0008312	molecular_function	7S RNA binding
v	0019843	molecular_function	rRNA binding
v	0030687	cellular_component	preribosome, large subunit precursor
v	1902626	biological_process	assembly of large subunit precursor of preribosome
w	0000055	biological_process	ribosomal large subunit export from nucleus
w	0000447	biological_process	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
w	0003674	molecular_function	molecular_function
w	0005515	molecular_function	protein binding
w	0005634	cellular_component	nucleus
w	0005654	cellular_component	nucleoplasm
w	0005730	cellular_component	nucleolus
w	0030687	cellular_component	preribosome, large subunit precursor
w	0034399	cellular_component	nuclear periphery
w	0042254	biological_process	ribosome biogenesis
w	0042273	biological_process	ribosomal large subunit biogenesis
x	0000027	biological_process	ribosomal large subunit assembly
x	0003674	molecular_function	molecular_function
x	0005515	molecular_function	protein binding
x	0005634	cellular_component	nucleus
x	0005730	cellular_component	nucleolus
x	0042254	biological_process	ribosome biogenesis
x	0110136	biological_process	protein-RNA complex remodeling
y	0000054	biological_process	ribosomal subunit export from nucleus
y	0000460	biological_process	maturation of 5.8S rRNA
y	0000463	biological_process	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
y	0000466	biological_process	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
y	0000470	biological_process	maturation of LSU-rRNA
y	0003743	molecular_function	translation initiation factor activity
y	0005515	molecular_function	protein binding
y	0005634	cellular_component	nucleus
y	0005730	cellular_component	nucleolus
y	0005737	cellular_component	cytoplasm
y	0005829	cellular_component	cytosol
y	0006364	biological_process	rRNA processing
y	0006412	biological_process	translation
y	0006413	biological_process	translational initiation
y	0030687	cellular_component	preribosome, large subunit precursor
y	0042254	biological_process	ribosome biogenesis
y	0042256	biological_process	cytosolic ribosome assembly
y	0042273	biological_process	ribosomal large subunit biogenesis
y	0043022	molecular_function	ribosome binding
y	0043023	molecular_function	ribosomal large subunit binding
y	1902626	biological_process	assembly of large subunit precursor of preribosome
z	0003674	molecular_function	molecular_function
z	0005634	cellular_component	nucleus
z	0005730	cellular_component	nucleolus
z	0008150	biological_process	biological_process
z	0030687	cellular_component	preribosome, large subunit precursor

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 201

Chain	Residue
I	CYS51
I	CYS54
I	HIS67
I	HIS73

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GTP b 701

Chain	Residue
b	SER182
b	ASP193
b	VAL194
b	PRO196
b	THR201
b	ASP220
b	ASN288
b	LYS289
b	ASP291
b	SER321
b	CYS322
b	GLN323
b	MG702
b	ASN177
b	VAL178
b	GLY179
b	LYS180
b	SER181

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG b 702

Chain	Residue
b	GLN195
b	TYR197
b	THR200
b	GTP701

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN j 100

Chain	Residue
j	CYS19
j	CYS22
j	CYS34
j	CYS37

---

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE GTP m 501

Chain	Residue
1	U2318
m	ASN260
m	LYS261
m	ASP263
m	LEU264
m	HIS287
m	ALA288
m	PRO324
m	ASN325
m	THR326
m	GLY327
m	LYS328
m	SER329
m	SER330
m	VAL343
m	ALA344
m	PRO345
m	PRO347
m	GLU349
m	THR350
m	MG502

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG m 502

Chain	Residue
m	ALA344
m	ILE346
m	PRO347
m	GTP501

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN p 501

Chain	Residue
p	CYS39
p	CYS42
p	CYS57
p	CYS59
p	CYS60

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN u 201

Chain	Residue
u	CYS9
u	ARG33
u	LYS35
u	CYS36
u	TRP51

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	23
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cih..CakyMetaialktHlkgkvH

Chain	Residue	Details
I	CYS51-HIS73

---

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AIVVrqakswrrr.DGvflyFedNagVI

Chain	Residue	Details
V	ALA76-ILE102

---

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVRLTadydaldI

Chain	Residue	Details
X	LYS120-ILE135

---

site_id	PS00051
Number of Residues	17
Details	RIBOSOMAL_L39E Ribosomal protein L39e signature. RTnntIryNakrRNWRR

Chain	Residue	Details
l	ARG30-ARG46

---

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LeqLSGQtpVqSkARyT

Chain	Residue	Details
J	LEU37-THR53

---

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinkyesspSHIELvV

Chain	Residue	Details
P	ARG126-VAL150

---

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PktRGVAmNPvD

Chain	Residue	Details
A	PRO197-ASP208

---

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FeqnemiDaiAvTkGHGfeGvthR

Chain	Residue	Details
B	PHE209-ARG232

---

site_id	PS00475
Number of Residues	32
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KILGkGrIpnvp.ViVkarfVSklAeekIraaG

Chain	Residue	Details
a	LYS111-GLY142

---

site_id	PS00526
Number of Residues	20
Details	RIBOSOMAL_L19E Ribosomal protein L19e signature. QKRLaAsvvgVGkrkVWLDP

Chain	Residue	Details
R	GLN7-PRO26

---

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. SLPKIKtVRKSIACV

Chain	Residue	Details
h	SER40-VAL54

---

site_id	PS00580
Number of Residues	21
Details	RIBOSOMAL_L32E Ribosomal protein L32e signature. FkRhhsdRyhRVaen..WRKqkG

Chain	Residue	Details
e	PHE17-GLY37

---

site_id	PS00634
Number of Residues	33
Details	RIBOSOMAL_L30 Ribosomal protein L30 signature. ILslLrLvEtnTgVfvkltknvypLLkvIapYV

Chain	Residue	Details
t	ILE162-VAL194
F	VAL102-VAL134

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. MVTGagDnTARIWDC

Chain	Residue	Details
x	MET159-CYS173
x	LEU251-THR265
x	LEU292-ILE306
x	ILE417-GLY431
x	LEU459-VAL473

---

site_id	PS00700
Number of Residues	22
Details	RIBOSOMAL_L6_2 Ribosomal protein L6 signature 2. QicrVrnKdiRkFlDGIYVshK

Chain	Residue	Details
H	GLN163-LYS184

---

site_id	PS00709
Number of Residues	25
Details	RIBOSOMAL_L30E_1 Ribosomal protein L30e signature 1. SgkytlGyKstVKslRqGksKlIII

Chain	Residue	Details
c	SER20-ILE44

---

site_id	PS00783
Number of Residues	24
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. LRGMVShktarGKaalerLkVFeG

Chain	Residue	Details
O	LEU84-GLY107

---

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NhneKryATaSAIaATAvaslvlaRGH

Chain	Residue	Details
C	ASN114-HIS140

---

site_id	PS00993
Number of Residues	21
Details	RIBOSOMAL_L30E_2 Ribosomal protein L30e signature 2. ELGTavGKlfrvgvVsIlEaG

Chain	Residue	Details
c	GLU76-GLY96

---

site_id	PS01077
Number of Residues	20
Details	RIBOSOMAL_L37E Ribosomal protein L37e signature. GTpSfGkRhnks.HtlCnRCG

Chain	Residue	Details
j	GLY4-GLY23

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CkkmgVPYaiVkGKarLG

Chain	Residue	Details
G	CYS170-GLY187

---

site_id	PS01104
Number of Residues	15
Details	RIBOSOMAL_L13E Ribosomal protein L13e signature. RaGRGFTLaEVkaaG

Chain	Residue	Details
L	ARG70-GLY84

---

site_id	PS01105
Number of Residues	22
Details	RIBOSOMAL_L35AE Ribosomal protein L35Ae signature. GKVtRtHGnsGvVrAtFrnnLP

Chain	Residue	Details
f	GLY69-PRO90

---

site_id	PS01106
Number of Residues	18
Details	RIBOSOMAL_L18E Ribosomal protein L18e signature. KaLflSKinRPpVSVsRI

Chain	Residue	Details
Q	LYS50-ILE67

---

site_id	PS01107
Number of Residues	12
Details	RIBOSOMAL_L27E Ribosomal protein L27e signature. GKNqWFFskLRF

Chain	Residue	Details
Z	GLY125-PHE136

---

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeVlVVrGskKGqe.GkI

Chain	Residue	Details
Y	ASP53-ILE70

---

site_id	PS01144
Number of Residues	15
Details	RIBOSOMAL_L31E Ribosomal protein L31e signature. VRLApeLNqAiWkRG

Chain	Residue	Details
d	VAL49-GLY63

---

site_id	PS01145
Number of Residues	14
Details	RIBOSOMAL_L34E Ribosomal protein L34e signature. TrSnKikvvKTPGG

Chain	Residue	Details
g	THR15-GLY28

---

site_id	PS01170
Number of Residues	19
Details	RIBOSOMAL_L6E Ribosomal protein L6e signature. NgvPLRRvnarYVIATSt.K

Chain	Residue	Details
E	ASN72-LYS90

---

site_id	PS01171
Number of Residues	26
Details	RIBOSOMAL_L21E Ribosomal protein L21e signature. GDiVdikangsiqk.GmpHkfYqGkTG

Chain	Residue	Details
T	GLY37-GLY62

---

site_id	PS01190
Number of Residues	11
Details	RIBOSOMAL_L36E Ribosomal protein L36e signature. PYERRlIDLIR

Chain	Residue	Details
i	PRO52-ARG62

---

site_id	PS01194
Number of Residues	24
Details	RIBOSOMAL_L15E Ribosomal protein L15e signature. DKARrLGYkAkqGFVIYRvRVrRG

Chain	Residue	Details
N	ASP46-GLY69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CK1 => ECO:0000255|HAMAP-Rule:MF_03132

Chain	Residue	Details
y	SER174
y	SER175
s	ASP336
c	LYS83

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198

Chain	Residue	Details
y	SER231
j	CYS22
j	CYS34
j	CYS37
R	LYS146
R	LYS186

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
t	THR120
A	LYS93
A	LYS119
A	LYS145

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358, ECO:0007744|PubMed:18407956

Chain	Residue	Details
t	SER278

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
B	LYS39
B	LYS136

---