3JBZ

Crystal structure of mTOR docked into EM map of dimeric ATM kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0016301	molecular_function	kinase activity
A	0044877	molecular_function	protein-containing complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP A 2601

Chain	Residue
A	GLN2167
A	MG2602
A	MGF2604
A	LYS2187
A	ILE2237
A	GLY2238
A	TRP2239
A	VAL2240
A	THR2245
A	ILE2356
A	ASP2357

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 2602

Chain	Residue
A	SER2342
A	ASN2343
A	ASP2357
A	ADP2601
A	MGF2604

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2603

Chain	Residue
A	ASP2357
A	MGF2604

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MGF A 2604

Chain	Residue
A	ASP2338
A	HIS2340
A	ASN2343
A	ASP2357
A	ADP2601
A	MG2602
A	MG2603

---

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDLRQDervmQ

Chain	Residue	Details
A	LEU2186-GLN2200

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMvgYILgLgDRHpsN

Chain	Residue	Details
A	SER2323-ASN2343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:29236692, ECO:0007744|PDB:6BCU, ECO:0007744|PDB:6BCX

Chain	Residue	Details
A	SER2165
A	MET2345
A	ILE2356
A	GLN2167
A	LEU2185
A	GLU2190
A	TYR2225
A	GLY2238
A	TRP2239
A	VAL2240
A	THR2245

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:29236692, ECO:0007744|PDB:6BCX

Chain	Residue	Details
A	LYS2187
A	ASN2343
A	ASP2357

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:21576368, ECO:0000269|PubMed:29150432

Chain	Residue	Details
A	SER2159

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21576368

Chain	Residue	Details
A	THR2164

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:24247430

Chain	Residue	Details
A	THR2173

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by RPS6KB1 => ECO:0000269|PubMed:15905173

Chain	Residue	Details
A	THR2446

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine; by RPS6KB1 => ECO:0000269|PubMed:15905173, ECO:0000269|PubMed:19145465, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER2448

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER2478

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:21576368, ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER2481

---