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3J4R

Pseudo-atomic model of the AKAP18-PKA Complex in a linear conformation derived from electron microscopy

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0010738biological_processregulation of protein kinase A signaling
A0016020cellular_componentmembrane
A0016208molecular_functionAMP binding
A0016324cellular_componentapical plasma membrane
A0016328cellular_componentlateral plasma membrane
A0016529cellular_componentsarcoplasmic reticulum
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030315cellular_componentT-tubule
A0032991cellular_componentprotein-containing complex
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0050804biological_processmodulation of chemical synaptic transmission
A0051018molecular_functionprotein kinase A binding
A0060306biological_processregulation of membrane repolarization
A0070382cellular_componentexocytic vesicle
A0071320biological_processcellular response to cAMP
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A1901381biological_processpositive regulation of potassium ion transmembrane transport
B0000166molecular_functionnucleotide binding
B0001932biological_processregulation of protein phosphorylation
B0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005952cellular_componentcAMP-dependent protein kinase complex
B0008603molecular_functioncAMP-dependent protein kinase regulator activity
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0030315cellular_componentT-tubule
B0030552molecular_functioncAMP binding
B0031698molecular_functionbeta-2 adrenergic receptor binding
B0032991cellular_componentprotein-containing complex
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0036094molecular_functionsmall molecule binding
B0042802molecular_functionidentical protein binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0048471cellular_componentperinuclear region of cytoplasm
B0050804biological_processmodulation of chemical synaptic transmission
B0098978cellular_componentglutamatergic synapse
C0000166molecular_functionnucleotide binding
C0001932biological_processregulation of protein phosphorylation
C0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005952cellular_componentcAMP-dependent protein kinase complex
C0008603molecular_functioncAMP-dependent protein kinase regulator activity
C0016020cellular_componentmembrane
C0019904molecular_functionprotein domain specific binding
C0030315cellular_componentT-tubule
C0030552molecular_functioncAMP binding
C0031698molecular_functionbeta-2 adrenergic receptor binding
C0032991cellular_componentprotein-containing complex
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0036094molecular_functionsmall molecule binding
C0042802molecular_functionidentical protein binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0098978cellular_componentglutamatergic synapse
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0001669cellular_componentacrosomal vesicle
D0001707biological_processmesoderm formation
D0001843biological_processneural tube closure
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004679molecular_functionAMP-activated protein kinase activity
D0004691molecular_functioncAMP-dependent protein kinase activity
D0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005929cellular_componentcilium
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0006611biological_processprotein export from nucleus
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0010737biological_processprotein kinase A signaling
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0019901molecular_functionprotein kinase binding
D0019904molecular_functionprotein domain specific binding
D0030145molecular_functionmanganese ion binding
D0031267molecular_functionsmall GTPase binding
D0031410cellular_componentcytoplasmic vesicle
D0031514cellular_componentmotile cilium
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0032024biological_processpositive regulation of insulin secretion
D0032991cellular_componentprotein-containing complex
D0034237molecular_functionprotein kinase A regulatory subunit binding
D0034605biological_processcellular response to heat
D0036126cellular_componentsperm flagellum
D0042995cellular_componentcell projection
D0043197cellular_componentdendritic spine
D0043457biological_processregulation of cellular respiration
D0044853cellular_componentplasma membrane raft
D0044877molecular_functionprotein-containing complex binding
D0045667biological_processregulation of osteoblast differentiation
D0045722biological_processpositive regulation of gluconeogenesis
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046827biological_processpositive regulation of protein export from nucleus
D0048240biological_processsperm capacitation
D0048471cellular_componentperinuclear region of cytoplasm
D0048792biological_processspontaneous exocytosis of neurotransmitter
D0050804biological_processmodulation of chemical synaptic transmission
D0051447biological_processnegative regulation of meiotic cell cycle
D0051726biological_processregulation of cell cycle
D0051966biological_processregulation of synaptic transmission, glutamatergic
D0061136biological_processregulation of proteasomal protein catabolic process
D0070417biological_processcellular response to cold
D0070613biological_processregulation of protein processing
D0071333biological_processcellular response to glucose stimulus
D0071374biological_processcellular response to parathyroid hormone stimulus
D0071377biological_processcellular response to glucagon stimulus
D0097546cellular_componentciliary base
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0106310molecular_functionprotein serine kinase activity
D1904262biological_processnegative regulation of TORC1 signaling
D1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
D1990044biological_processprotein localization to lipid droplet
D2000810biological_processregulation of bicellular tight junction assembly
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000166molecular_functionnucleotide binding
E0000287molecular_functionmagnesium ion binding
E0001669cellular_componentacrosomal vesicle
E0001707biological_processmesoderm formation
E0001843biological_processneural tube closure
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0004679molecular_functionAMP-activated protein kinase activity
E0004691molecular_functioncAMP-dependent protein kinase activity
E0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005813cellular_componentcentrosome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005929cellular_componentcilium
E0005930cellular_componentaxoneme
E0005952cellular_componentcAMP-dependent protein kinase complex
E0006397biological_processmRNA processing
E0006468biological_processprotein phosphorylation
E0006611biological_processprotein export from nucleus
E0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
E0008284biological_processpositive regulation of cell population proliferation
E0010737biological_processprotein kinase A signaling
E0016020cellular_componentmembrane
E0016301molecular_functionkinase activity
E0016310biological_processphosphorylation
E0016607cellular_componentnuclear speck
E0016740molecular_functiontransferase activity
E0018105biological_processpeptidyl-serine phosphorylation
E0019901molecular_functionprotein kinase binding
E0019904molecular_functionprotein domain specific binding
E0030145molecular_functionmanganese ion binding
E0031267molecular_functionsmall GTPase binding
E0031410cellular_componentcytoplasmic vesicle
E0031514cellular_componentmotile cilium
E0031594cellular_componentneuromuscular junction
E0031625molecular_functionubiquitin protein ligase binding
E0032024biological_processpositive regulation of insulin secretion
E0032991cellular_componentprotein-containing complex
E0034237molecular_functionprotein kinase A regulatory subunit binding
E0034605biological_processcellular response to heat
E0036126cellular_componentsperm flagellum
E0042995cellular_componentcell projection
E0043197cellular_componentdendritic spine
E0043457biological_processregulation of cellular respiration
E0044853cellular_componentplasma membrane raft
E0044877molecular_functionprotein-containing complex binding
E0045667biological_processregulation of osteoblast differentiation
E0045722biological_processpositive regulation of gluconeogenesis
E0045879biological_processnegative regulation of smoothened signaling pathway
E0046827biological_processpositive regulation of protein export from nucleus
E0048240biological_processsperm capacitation
E0048471cellular_componentperinuclear region of cytoplasm
E0048792biological_processspontaneous exocytosis of neurotransmitter
E0050804biological_processmodulation of chemical synaptic transmission
E0051447biological_processnegative regulation of meiotic cell cycle
E0051726biological_processregulation of cell cycle
E0051966biological_processregulation of synaptic transmission, glutamatergic
E0061136biological_processregulation of proteasomal protein catabolic process
E0070417biological_processcellular response to cold
E0070613biological_processregulation of protein processing
E0071333biological_processcellular response to glucose stimulus
E0071374biological_processcellular response to parathyroid hormone stimulus
E0071377biological_processcellular response to glucagon stimulus
E0097546cellular_componentciliary base
E0098793cellular_componentpresynapse
E0098794cellular_componentpostsynapse
E0098978cellular_componentglutamatergic synapse
E0099170biological_processpostsynaptic modulation of chemical synaptic transmission
E0106310molecular_functionprotein serine kinase activity
E1904262biological_processnegative regulation of TORC1 signaling
E1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
E1990044biological_processprotein localization to lipid droplet
E2000810biological_processregulation of bicellular tight junction assembly
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIdQGDdGDnFYVIerG
ChainResidueDetails
BVAL164-GLY180
BILE286-GLY302

site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALmyntp......RAAtIiA
ChainResidueDetails
BPHE204-ALA221
BPHE334-ALA351

site_idPS00430
Number of Residues56
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mshiqipagltellqgytvevlrqqppdlvdfaveyftrlrearrqes...................................................................DTFIVSPT
ChainResidueDetails
BMET1-THR56

site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK
ChainResidueDetails
DLEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
DLEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING:
ChainResidueDetails
BLEU137
CLEU259
CGLU336
CARG345
BGLU206
BARG215
BLEU259
BGLU336
BARG345
CLEU137
CGLU206
CARG215

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P13861, ECO:0000305
ChainResidueDetails
BSER2
CSER2
DGLU121
DLYS168
ELEU49
ELYS72
EGLU121
ELYS168

site_idSWS_FT_FI3
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13861
ChainResidueDetails
BSER48
BSER75
BSER77
BSER348
CSER48
CSER75
CSER77
CSER348

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER97
CSER97

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000250|UniProtKB:P00515
ChainResidueDetails
BTHR213
CTHR213
ETHR48
ETHR195

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BSER393
CSER393

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:22323819, ECO:0000269|PubMed:8395513, ECO:0000269|PubMed:9707564
ChainResidueDetails
DTHR197
ETHR197

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21866565
ChainResidueDetails
DTYR330
ETYR330

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000305|PubMed:8395513
ChainResidueDetails
DSER338
ESER338

site_idSWS_FT_FI10
Number of Residues2
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:11141074
ChainResidueDetails
DGLY1
EGLY1

218853

PDB entries from 2024-04-24

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