3J4Q

Pseudo-atomic model of the AKAP18-PKA complex in a bent conformation derived from electron microscopy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001508	biological_process	action potential
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0016208	molecular_function	AMP binding
A	0016324	cellular_component	apical plasma membrane
A	0016328	cellular_component	lateral plasma membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030315	cellular_component	T-tubule
A	0032991	cellular_component	protein-containing complex
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051018	molecular_function	protein kinase A binding
A	0060306	biological_process	regulation of membrane repolarization
A	0070382	cellular_component	exocytic vesicle
A	0071320	biological_process	cellular response to cAMP
A	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
A	0141156	biological_process	cAMP/PKA signal transduction
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0001932	biological_process	regulation of protein phosphorylation
B	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005930	cellular_component	axoneme
B	0005952	cellular_component	cAMP-dependent protein kinase complex
B	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
B	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
B	0019904	molecular_function	protein domain specific binding
B	0030315	cellular_component	T-tubule
B	0030552	molecular_function	cAMP binding
B	0031588	cellular_component	nucleotide-activated protein kinase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031698	molecular_function	beta-2 adrenergic receptor binding
B	0032991	cellular_component	protein-containing complex
B	0034236	molecular_function	protein kinase A catalytic subunit binding
B	0036094	molecular_function	small molecule binding
B	0042802	molecular_function	identical protein binding
B	0044853	cellular_component	plasma membrane raft
B	0044877	molecular_function	protein-containing complex binding
B	0045202	cellular_component	synapse
B	0045859	biological_process	regulation of protein kinase activity
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0098978	cellular_component	glutamatergic synapse
B	0141162	biological_process	negative regulation of cAMP/PKA signal transduction
C	0000166	molecular_function	nucleotide binding
C	0001932	biological_process	regulation of protein phosphorylation
C	0004862	molecular_function	cAMP-dependent protein kinase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0005952	cellular_component	cAMP-dependent protein kinase complex
C	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
C	0008603	molecular_function	cAMP-dependent protein kinase regulator activity
C	0019904	molecular_function	protein domain specific binding
C	0030315	cellular_component	T-tubule
C	0030552	molecular_function	cAMP binding
C	0031588	cellular_component	nucleotide-activated protein kinase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031698	molecular_function	beta-2 adrenergic receptor binding
C	0032991	cellular_component	protein-containing complex
C	0034236	molecular_function	protein kinase A catalytic subunit binding
C	0036094	molecular_function	small molecule binding
C	0042802	molecular_function	identical protein binding
C	0044853	cellular_component	plasma membrane raft
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0045859	biological_process	regulation of protein kinase activity
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0098978	cellular_component	glutamatergic synapse
C	0141162	biological_process	negative regulation of cAMP/PKA signal transduction
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0001669	cellular_component	acrosomal vesicle
D	0001707	biological_process	mesoderm formation
D	0001843	biological_process	neural tube closure
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004691	molecular_function	cAMP-dependent protein kinase activity
D	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005811	cellular_component	lipid droplet
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005930	cellular_component	axoneme
D	0005952	cellular_component	cAMP-dependent protein kinase complex
D	0006338	biological_process	chromatin remodeling
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
D	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0010898	biological_process	positive regulation of triglyceride catabolic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0018105	biological_process	peptidyl-serine phosphorylation
D	0018107	biological_process	peptidyl-threonine phosphorylation
D	0019870	molecular_function	potassium channel inhibitor activity
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0030007	biological_process	intracellular potassium ion homeostasis
D	0030145	molecular_function	manganese ion binding
D	0031267	molecular_function	small GTPase binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0031514	cellular_component	motile cilium
D	0031588	cellular_component	nucleotide-activated protein kinase complex
D	0031594	cellular_component	neuromuscular junction
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032991	cellular_component	protein-containing complex
D	0034237	molecular_function	protein kinase A regulatory subunit binding
D	0034605	biological_process	cellular response to heat
D	0036126	cellular_component	sperm flagellum
D	0038110	biological_process	interleukin-2-mediated signaling pathway
D	0038202	biological_process	TORC1 signaling
D	0043457	biological_process	regulation of cellular respiration
D	0044853	cellular_component	plasma membrane raft
D	0044877	molecular_function	protein-containing complex binding
D	0045542	biological_process	positive regulation of cholesterol biosynthetic process
D	0045667	biological_process	regulation of osteoblast differentiation
D	0045722	biological_process	positive regulation of gluconeogenesis
D	0045820	biological_process	negative regulation of glycolytic process
D	0045879	biological_process	negative regulation of smoothened signaling pathway
D	0046777	biological_process	protein autophosphorylation
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0048240	biological_process	sperm capacitation
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0048792	biological_process	spontaneous exocytosis of neurotransmitter
D	0050766	biological_process	positive regulation of phagocytosis
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0051447	biological_process	negative regulation of meiotic cell cycle
D	0051726	biological_process	regulation of cell cycle
D	0051966	biological_process	regulation of synaptic transmission, glutamatergic
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0070417	biological_process	cellular response to cold
D	0070507	biological_process	regulation of microtubule cytoskeleton organization
D	0070613	biological_process	regulation of protein processing
D	0071333	biological_process	cellular response to glucose stimulus
D	0071374	biological_process	cellular response to parathyroid hormone stimulus
D	0071377	biological_process	cellular response to glucagon stimulus
D	0097225	cellular_component	sperm midpiece
D	0097546	cellular_component	ciliary base
D	0098793	cellular_component	presynapse
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
D	0106310	molecular_function	protein serine kinase activity
D	0120186	biological_process	negative regulation of protein localization to chromatin
D	0140198	molecular_function	histone H1-4S35 kinase activity
D	0141156	biological_process	cAMP/PKA signal transduction
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
D	1990044	biological_process	protein localization to lipid droplet
D	2000810	biological_process	regulation of bicellular tight junction assembly
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0001669	cellular_component	acrosomal vesicle
E	0001707	biological_process	mesoderm formation
E	0001843	biological_process	neural tube closure
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004691	molecular_function	cAMP-dependent protein kinase activity
E	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005811	cellular_component	lipid droplet
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005930	cellular_component	axoneme
E	0005952	cellular_component	cAMP-dependent protein kinase complex
E	0006338	biological_process	chromatin remodeling
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
E	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
E	0008284	biological_process	positive regulation of cell population proliferation
E	0010898	biological_process	positive regulation of triglyceride catabolic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016607	cellular_component	nuclear speck
E	0016740	molecular_function	transferase activity
E	0018105	biological_process	peptidyl-serine phosphorylation
E	0018107	biological_process	peptidyl-threonine phosphorylation
E	0019870	molecular_function	potassium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030007	biological_process	intracellular potassium ion homeostasis
E	0030145	molecular_function	manganese ion binding
E	0031267	molecular_function	small GTPase binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0031588	cellular_component	nucleotide-activated protein kinase complex
E	0031594	cellular_component	neuromuscular junction
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031669	biological_process	cellular response to nutrient levels
E	0032991	cellular_component	protein-containing complex
E	0034237	molecular_function	protein kinase A regulatory subunit binding
E	0034605	biological_process	cellular response to heat
E	0036126	cellular_component	sperm flagellum
E	0038110	biological_process	interleukin-2-mediated signaling pathway
E	0038202	biological_process	TORC1 signaling
E	0043457	biological_process	regulation of cellular respiration
E	0044853	cellular_component	plasma membrane raft
E	0044877	molecular_function	protein-containing complex binding
E	0045542	biological_process	positive regulation of cholesterol biosynthetic process
E	0045667	biological_process	regulation of osteoblast differentiation
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045820	biological_process	negative regulation of glycolytic process
E	0045879	biological_process	negative regulation of smoothened signaling pathway
E	0046777	biological_process	protein autophosphorylation
E	0046827	biological_process	positive regulation of protein export from nucleus
E	0048240	biological_process	sperm capacitation
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048792	biological_process	spontaneous exocytosis of neurotransmitter
E	0050766	biological_process	positive regulation of phagocytosis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0051447	biological_process	negative regulation of meiotic cell cycle
E	0051726	biological_process	regulation of cell cycle
E	0051966	biological_process	regulation of synaptic transmission, glutamatergic
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0070417	biological_process	cellular response to cold
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0070613	biological_process	regulation of protein processing
E	0071333	biological_process	cellular response to glucose stimulus
E	0071374	biological_process	cellular response to parathyroid hormone stimulus
E	0071377	biological_process	cellular response to glucagon stimulus
E	0097225	cellular_component	sperm midpiece
E	0097546	cellular_component	ciliary base
E	0098793	cellular_component	presynapse
E	0098794	cellular_component	postsynapse
E	0098978	cellular_component	glutamatergic synapse
E	0099170	biological_process	postsynaptic modulation of chemical synaptic transmission
E	0106310	molecular_function	protein serine kinase activity
E	0120186	biological_process	negative regulation of protein localization to chromatin
E	0140198	molecular_function	histone H1-4S35 kinase activity
E	0141156	biological_process	cAMP/PKA signal transduction
E	1904262	biological_process	negative regulation of TORC1 signaling
E	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
E	1990044	biological_process	protein localization to lipid droplet
E	2000810	biological_process	regulation of bicellular tight junction assembly

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhkesgnh..........YAMK

Chain	Residue	Details
D	LEU49-LYS72

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI

Chain	Residue	Details
D	LEU162-ILE174

---

site_id	PS00430
Number of Residues	56
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mshiqipagltellqgytvevlrqqppdlvdfaveyftrlrearrqes...................................................................DTFIVSPT

Chain	Residue	Details
B	MET1-THR56

---

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIdQGDdGDnFYVIerG

Chain	Residue	Details
B	VAL164-GLY180
B	ILE286-GLY302

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALmyntp......RAAtIiA

Chain	Residue	Details
B	PHE204-ALA221
B	PHE334-ALA351

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Region: {"description":"RII-binding","evidences":[{"source":"UniProtKB","id":"O43687","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18082768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	278
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P13861","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"UniProtKB","id":"P00515","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	508
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P17612","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"22323819","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9707564","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"8395513","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---