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3J41

Pseudo-atomic model of the Aquaporin-0/Calmodulin complex derived from electron microscopy

Functional Information from GO Data
ChainGOidnamespacecontents
A0002088biological_processlens development in camera-type eye
A0005212molecular_functionstructural constituent of eye lens
A0005516molecular_functioncalmodulin binding
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0006833biological_processwater transport
A0007601biological_processvisual perception
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0045785biological_processpositive regulation of cell adhesion
A0050896biological_processresponse to stimulus
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070161cellular_componentanchoring junction
A1990349biological_processgap junction-mediated intercellular transport
B0002088biological_processlens development in camera-type eye
B0005212molecular_functionstructural constituent of eye lens
B0005516molecular_functioncalmodulin binding
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0006833biological_processwater transport
B0007601biological_processvisual perception
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0045785biological_processpositive regulation of cell adhesion
B0050896biological_processresponse to stimulus
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070161cellular_componentanchoring junction
B1990349biological_processgap junction-mediated intercellular transport
C0002088biological_processlens development in camera-type eye
C0005212molecular_functionstructural constituent of eye lens
C0005516molecular_functioncalmodulin binding
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0006833biological_processwater transport
C0007601biological_processvisual perception
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0045785biological_processpositive regulation of cell adhesion
C0050896biological_processresponse to stimulus
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070161cellular_componentanchoring junction
C1990349biological_processgap junction-mediated intercellular transport
D0002088biological_processlens development in camera-type eye
D0005212molecular_functionstructural constituent of eye lens
D0005516molecular_functioncalmodulin binding
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0006833biological_processwater transport
D0007601biological_processvisual perception
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0045785biological_processpositive regulation of cell adhesion
D0050896biological_processresponse to stimulus
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070161cellular_componentanchoring junction
D1990349biological_processgap junction-mediated intercellular transport
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0005929cellular_componentcilium
E0007186biological_processG protein-coupled receptor signaling pathway
E0008076cellular_componentvoltage-gated potassium channel complex
E0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
E0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0030234molecular_functionenzyme regulator activity
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031954biological_processpositive regulation of protein autophosphorylation
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032516biological_processpositive regulation of phosphoprotein phosphatase activity
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035307biological_processpositive regulation of protein dephosphorylation
E0035458biological_processcellular response to interferon-beta
E0042995cellular_componentcell projection
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0071902biological_processpositive regulation of protein serine/threonine kinase activity
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0098901biological_processregulation of cardiac muscle cell action potential
E0140056biological_processorganelle localization by membrane tethering
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0007186biological_processG protein-coupled receptor signaling pathway
F0008076cellular_componentvoltage-gated potassium channel complex
F0010800biological_processpositive regulation of peptidyl-threonine phosphorylation
F0010801biological_processnegative regulation of peptidyl-threonine phosphorylation
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0030234molecular_functionenzyme regulator activity
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031954biological_processpositive regulation of protein autophosphorylation
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032516biological_processpositive regulation of phosphoprotein phosphatase activity
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035307biological_processpositive regulation of protein dephosphorylation
F0035458biological_processcellular response to interferon-beta
F0042995cellular_componentcell projection
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051343biological_processpositive regulation of cyclic-nucleotide phosphodiesterase activity
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0071902biological_processpositive regulation of protein serine/threonine kinase activity
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0098901biological_processregulation of cardiac muscle cell action potential
F0140056biological_processorganelle localization by membrane tethering
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 201
ChainResidue
EASP20
EASP22
EASP24
ETHR26

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 202
ChainResidue
EASP58
EASN60
ETHR62
EASP64

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 203
ChainResidue
EASP95
EASN97
ETYR99
EGLU104
EASP93

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 204
ChainResidue
EASP129
EASP131
EASP133
EGLN135
EGLU140

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 201
ChainResidue
FASP20
FASP22
FASP24
FTHR26

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 202
ChainResidue
FASP58
FASN60
FTHR62
FASP64

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 203
ChainResidue
FASP93
FASP95
FASN97
FTYR99
FGLU104

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 204
ChainResidue
FASP129
FASP131
FASP133
FGLN135
FGLU140

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGLGSLLYdFllfprlksvserl.....SILK
ChainResidueDetails
AILE210-LYS238

site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HVNPAVTFA
ChainResidueDetails
AHIS66-ALA74

site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
EASP20-LEU32
EASP56-PHE68
EASP93-LEU105
EASP129-PHE141

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues264
DetailsTOPO_DOM: Cytoplasmic
ChainResidueDetails
AMET1-SER8
CSER79-LEU84
CTHR148-SER159
CASP220-LEU263
DMET1-SER8
DSER79-LEU84
DTHR148-SER159
DASP220-LEU263
FASP58
FASN60
FTHR62
ASER79-LEU84
FGLU67
ATHR148-SER159
AASP220-LEU263
BMET1-SER8
BSER79-LEU84
BTHR148-SER159
BASP220-LEU263
CMET1-SER8

site_idSWS_FT_FI2
Number of Residues484
DetailsTRANSMEM: Helical
ChainResidueDetails
APHE9-LEU32
BVAL127-ALA147
BVAL160-MET176
BHIS201-TYR219
CPHE9-LEU32
CLEU39-HIS61
CARG85-VAL107
CVAL127-ALA147
CVAL160-MET176
CHIS201-TYR219
DPHE9-LEU32
ALEU39-HIS61
DLEU39-HIS61
DARG85-VAL107
DVAL127-ALA147
DVAL160-MET176
DHIS201-TYR219
AARG85-VAL107
AVAL127-ALA147
AVAL160-MET176
AHIS201-TYR219
BPHE9-LEU32
BLEU39-HIS61
BARG85-VAL107

site_idSWS_FT_FI3
Number of Residues112
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
AARG33-PRO38
DARG33-PRO38
DTHR108-SER126
DTHR195-ASN200
ATHR108-SER126
ATHR195-ASN200
BARG33-PRO38
BTHR108-SER126
BTHR195-ASN200
CARG33-PRO38
CTHR108-SER126
CTHR195-ASN200

site_idSWS_FT_FI4
Number of Residues44
DetailsINTRAMEM:
ChainResidueDetails
AILE62-VAL67
ATYR177-MET183
BILE62-VAL67
BTYR177-MET183
CILE62-VAL67
CTYR177-MET183
DILE62-VAL67
DTYR177-MET183

site_idSWS_FT_FI5
Number of Residues80
DetailsINTRAMEM: Helical
ChainResidueDetails
AASN68-GLY78
AASN184-LEU194
BASN68-GLY78
BASN184-LEU194
CASN68-GLY78
CASN184-LEU194
DASN68-GLY78
DASN184-LEU194

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Important for water channel gating => ECO:0000250
ChainResidueDetails
ATYR149
BTYR149
CTYR149
DTYR149

site_idSWS_FT_FI7
Number of Residues4
DetailsSITE: Interaction with BFSP1 => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
AASN246
BASN246
CASN246
DASN246

site_idSWS_FT_FI8
Number of Residues4
DetailsSITE: interaction with BFSP1 => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
AGLU250
BGLU250
CGLU250
DGLU250

site_idSWS_FT_FI9
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
ASER235
DSER235
DSER243
DSER245
ASER243
ASER245
BSER235
BSER243
BSER245
CSER235
CSER243
CSER245

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ETHR110
FTHR110

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
ELYS115
FLYS115

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ETYR138
FTYR138

site_idSWS_FT_FI13
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ELYS21
FLYS21

218853

PDB entries from 2024-04-24

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