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3J41

Pseudo-atomic model of the Aquaporin-0/Calmodulin complex derived from electron microscopy

Functional Information from GO Data
ChainGOidnamespacecontents
A0002088biological_processlens development in camera-type eye
A0005212molecular_functionstructural constituent of eye lens
A0005516molecular_functioncalmodulin binding
A0005886cellular_componentplasma membrane
A0006833biological_processwater transport
A0007601biological_processvisual perception
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0034109biological_processhomotypic cell-cell adhesion
A0036438biological_processmaintenance of lens transparency
A0055085biological_processtransmembrane transport
A0070161cellular_componentanchoring junction
A0098631molecular_functioncell adhesion mediator activity
A1990349biological_processgap junction-mediated intercellular transport
B0002088biological_processlens development in camera-type eye
B0005212molecular_functionstructural constituent of eye lens
B0005516molecular_functioncalmodulin binding
B0005886cellular_componentplasma membrane
B0006833biological_processwater transport
B0007601biological_processvisual perception
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0034109biological_processhomotypic cell-cell adhesion
B0036438biological_processmaintenance of lens transparency
B0055085biological_processtransmembrane transport
B0070161cellular_componentanchoring junction
B0098631molecular_functioncell adhesion mediator activity
B1990349biological_processgap junction-mediated intercellular transport
C0002088biological_processlens development in camera-type eye
C0005212molecular_functionstructural constituent of eye lens
C0005516molecular_functioncalmodulin binding
C0005886cellular_componentplasma membrane
C0006833biological_processwater transport
C0007601biological_processvisual perception
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0034109biological_processhomotypic cell-cell adhesion
C0036438biological_processmaintenance of lens transparency
C0055085biological_processtransmembrane transport
C0070161cellular_componentanchoring junction
C0098631molecular_functioncell adhesion mediator activity
C1990349biological_processgap junction-mediated intercellular transport
D0002088biological_processlens development in camera-type eye
D0005212molecular_functionstructural constituent of eye lens
D0005516molecular_functioncalmodulin binding
D0005886cellular_componentplasma membrane
D0006833biological_processwater transport
D0007601biological_processvisual perception
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0034109biological_processhomotypic cell-cell adhesion
D0036438biological_processmaintenance of lens transparency
D0055085biological_processtransmembrane transport
D0070161cellular_componentanchoring junction
D0098631molecular_functioncell adhesion mediator activity
D1990349biological_processgap junction-mediated intercellular transport
E0000086biological_processG2/M transition of mitotic cell cycle
E0000922cellular_componentspindle pole
E0002027biological_processregulation of heart rate
E0005246molecular_functioncalcium channel regulator activity
E0005509molecular_functioncalcium ion binding
E0005513biological_processdetection of calcium ion
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005813cellular_componentcentrosome
E0005819cellular_componentspindle
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005876cellular_componentspindle microtubule
E0005886cellular_componentplasma membrane
E0005929cellular_componentcilium
E0007186biological_processG protein-coupled receptor signaling pathway
E0007259biological_processcell surface receptor signaling pathway via JAK-STAT
E0008076cellular_componentvoltage-gated potassium channel complex
E0010856molecular_functionadenylate cyclase activator activity
E0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E0016020cellular_componentmembrane
E0016240biological_processautophagosome membrane docking
E0019855molecular_functioncalcium channel inhibitor activity
E0019901molecular_functionprotein kinase binding
E0021762biological_processsubstantia nigra development
E0030017cellular_componentsarcomere
E0030672cellular_componentsynaptic vesicle membrane
E0031432molecular_functiontitin binding
E0031514cellular_componentmotile cilium
E0031982cellular_componentvesicle
E0032465biological_processregulation of cytokinesis
E0032991cellular_componentprotein-containing complex
E0034704cellular_componentcalcium channel complex
E0035458biological_processcellular response to interferon-beta
E0042995cellular_componentcell projection
E0043209cellular_componentmyelin sheath
E0043539molecular_functionprotein serine/threonine kinase activator activity
E0044305cellular_componentcalyx of Held
E0044325molecular_functiontransmembrane transporter binding
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0048306molecular_functioncalcium-dependent protein binding
E0050848biological_processregulation of calcium-mediated signaling
E0051592biological_processresponse to calcium ion
E0055117biological_processregulation of cardiac muscle contraction
E0060291biological_processlong-term synaptic potentiation
E0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
E0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
E0071346biological_processcellular response to type II interferon
E0072542molecular_functionprotein phosphatase activator activity
E0097225cellular_componentsperm midpiece
E0097720biological_processcalcineurin-mediated signaling
E0098901biological_processregulation of cardiac muscle cell action potential
E0099523cellular_componentpresynaptic cytosol
E0140056biological_processorganelle localization by membrane tethering
E0140238biological_processpresynaptic endocytosis
E0141110molecular_functiontransporter inhibitor activity
E1901842biological_processnegative regulation of high voltage-gated calcium channel activity
E1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
E1902494cellular_componentcatalytic complex
E1905913biological_processnegative regulation of calcium ion export across plasma membrane
E1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
F0000086biological_processG2/M transition of mitotic cell cycle
F0000922cellular_componentspindle pole
F0002027biological_processregulation of heart rate
F0005246molecular_functioncalcium channel regulator activity
F0005509molecular_functioncalcium ion binding
F0005513biological_processdetection of calcium ion
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005819cellular_componentspindle
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005876cellular_componentspindle microtubule
F0005886cellular_componentplasma membrane
F0005929cellular_componentcilium
F0007186biological_processG protein-coupled receptor signaling pathway
F0007259biological_processcell surface receptor signaling pathway via JAK-STAT
F0008076cellular_componentvoltage-gated potassium channel complex
F0010856molecular_functionadenylate cyclase activator activity
F0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F0016020cellular_componentmembrane
F0016240biological_processautophagosome membrane docking
F0019855molecular_functioncalcium channel inhibitor activity
F0019901molecular_functionprotein kinase binding
F0021762biological_processsubstantia nigra development
F0030017cellular_componentsarcomere
F0030672cellular_componentsynaptic vesicle membrane
F0031432molecular_functiontitin binding
F0031514cellular_componentmotile cilium
F0031982cellular_componentvesicle
F0032465biological_processregulation of cytokinesis
F0032991cellular_componentprotein-containing complex
F0034704cellular_componentcalcium channel complex
F0035458biological_processcellular response to interferon-beta
F0042995cellular_componentcell projection
F0043209cellular_componentmyelin sheath
F0043539molecular_functionprotein serine/threonine kinase activator activity
F0044305cellular_componentcalyx of Held
F0044325molecular_functiontransmembrane transporter binding
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0048306molecular_functioncalcium-dependent protein binding
F0050848biological_processregulation of calcium-mediated signaling
F0051592biological_processresponse to calcium ion
F0055117biological_processregulation of cardiac muscle contraction
F0060291biological_processlong-term synaptic potentiation
F0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
F0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
F0071346biological_processcellular response to type II interferon
F0072542molecular_functionprotein phosphatase activator activity
F0097225cellular_componentsperm midpiece
F0097720biological_processcalcineurin-mediated signaling
F0098901biological_processregulation of cardiac muscle cell action potential
F0099523cellular_componentpresynaptic cytosol
F0140056biological_processorganelle localization by membrane tethering
F0140238biological_processpresynaptic endocytosis
F0141110molecular_functiontransporter inhibitor activity
F1901842biological_processnegative regulation of high voltage-gated calcium channel activity
F1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
F1902494cellular_componentcatalytic complex
F1905913biological_processnegative regulation of calcium ion export across plasma membrane
F1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 201
ChainResidue
EASP20
EASP22
EASP24
ETHR26

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 202
ChainResidue
EASP58
EASN60
ETHR62
EASP64

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 203
ChainResidue
EASP95
EASN97
ETYR99
EGLU104
EASP93

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA E 204
ChainResidue
EASP129
EASP131
EASP133
EGLN135
EGLU140

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 201
ChainResidue
FASP20
FASP22
FASP24
FTHR26

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 202
ChainResidue
FASP58
FASN60
FTHR62
FASP64

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 203
ChainResidue
FASP93
FASP95
FASN97
FTYR99
FGLU104

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA F 204
ChainResidue
FASP129
FASP131
FASP133
FGLN135
FGLU140

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
EASP20-LEU32
EASP56-PHE68
EASP93-LEU105
EASP129-PHE141

site_idPS00107
Number of Residues29
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGLGSLLYdFllfprlksvserl.....SILK
ChainResidueDetails
AILE210-LYS238

site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HVNPAVTFA
ChainResidueDetails
AHIS66-ALA74

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues300
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:16319884
ChainResidueDetails
AMET1-ALA12
BTYR219-LEU263
CMET1-ALA12
CGLY60-SER63
CVAL77-ARG85
CTHR148-LEU157
CTYR219-LEU263
DMET1-ALA12
DGLY60-SER63
DVAL77-ARG85
DTHR148-LEU157
AGLY60-SER63
DTYR219-LEU263
AVAL77-ARG85
ATHR148-LEU157
ATYR219-LEU263
BMET1-ALA12
BGLY60-SER63
BVAL77-ARG85
BTHR148-LEU157

site_idSWS_FT_FI2
Number of Residues68
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AILE13-ALA30
FGLU104
BILE13-ALA30
CILE13-ALA30
DILE13-ALA30
EGLU104
FASP93
FASP95
FASN97
FTYR99

site_idSWS_FT_FI3
Number of Residues140
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:16319884
ChainResidueDetails
ASER31-HIS40
CVAL107-SER126
CMET176-TYR177
CLEU194-ASN200
DSER31-HIS40
DVAL107-SER126
DMET176-TYR177
DLEU194-ASN200
AVAL107-SER126
AMET176-TYR177
ALEU194-ASN200
BSER31-HIS40
BVAL107-SER126
BMET176-TYR177
BLEU194-ASN200
CSER31-HIS40

site_idSWS_FT_FI4
Number of Residues72
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AVAL41-VAL59
BVAL41-VAL59
CVAL41-VAL59
DVAL41-VAL59

site_idSWS_FT_FI5
Number of Residues108
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AGLY64-LEU76
ATYR178-ILE193
BGLY64-LEU76
BTYR178-ILE193
CGLY64-LEU76
CTYR178-ILE193
DGLY64-LEU76
DTYR178-ILE193

site_idSWS_FT_FI6
Number of Residues80
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AALA86-SER106
BALA86-SER106
CALA86-SER106
DALA86-SER106

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AVAL127-ALA147
BVAL127-ALA147
CVAL127-ALA147
DVAL127-ALA147

site_idSWS_FT_FI8
Number of Residues68
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AGLY158-GLY175
BGLY158-GLY175
CGLY158-GLY175
DGLY158-GLY175

site_idSWS_FT_FI9
Number of Residues68
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:16319884, ECO:0007744|PDB:2B6O
ChainResidueDetails
AHIS201-LEU218
BHIS201-LEU218
CHIS201-LEU218
DHIS201-LEU218

site_idSWS_FT_FI10
Number of Residues4
DetailsSITE: Important for water channel gating => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
ATYR149
BTYR149
CTYR149
DTYR149

site_idSWS_FT_FI11
Number of Residues8
DetailsSITE: Cleavage; promotes interactions between tetramers from adjoining membranes => ECO:0000269|PubMed:15351655
ChainResidueDetails
ALEU234
ASER243
BLEU234
BSER243
CLEU234
CSER243
DLEU234
DSER243

site_idSWS_FT_FI12
Number of Residues4
DetailsSITE: Interaction with BFSP1 => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
AASN246
BASN246
CASN246
DASN246

site_idSWS_FT_FI13
Number of Residues4
DetailsSITE: interaction with BFSP1 => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
AGLU250
BGLU250
CGLU250
DGLU250

site_idSWS_FT_FI14
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06624
ChainResidueDetails
ASER235
DSER235
DSER243
DSER245
ASER243
ASER245
BSER235
BSER243
BSER245
CSER235
CSER243
CSER245

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PDB entries from 2025-06-11

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