Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 929 A 500 |
| Chain | Residue |
| A | GLY59 |
| A | THR120 |
| A | GLN121 |
| A | GLY122 |
| A | LYS155 |
| A | PHE156 |
| A | ILE158 |
| A | ILE174 |
| A | TYR246 |
| A | ASP276 |
| A | SER277 |
| A | GLN60 |
| A | GLY278 |
| A | THR279 |
| A | THR280 |
| A | ASN281 |
| A | ARG283 |
| A | SER373 |
| A | HOH501 |
| A | GLY61 |
| A | ASP80 |
| A | GLY82 |
| A | SER83 |
| A | VAL117 |
| A | PRO118 |
| A | TYR119 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE 929 B 500 |
| Chain | Residue |
| B | GLY59 |
| B | GLN60 |
| B | GLY61 |
| B | ASP80 |
| B | GLY82 |
| B | VAL117 |
| B | PRO118 |
| B | TYR119 |
| B | THR120 |
| B | GLN121 |
| B | GLY122 |
| B | LYS155 |
| B | PHE156 |
| B | ILE158 |
| B | TRP163 |
| B | ILE174 |
| B | TYR246 |
| B | ASP276 |
| B | SER277 |
| B | GLY278 |
| B | THR279 |
| B | THR280 |
| B | ASN281 |
| B | ARG283 |
| B | SER373 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE 929 C 500 |
| Chain | Residue |
| C | GLY59 |
| C | GLN60 |
| C | GLY61 |
| C | ASP80 |
| C | GLY82 |
| C | VAL117 |
| C | PRO118 |
| C | TYR119 |
| C | THR120 |
| C | GLN121 |
| C | GLY122 |
| C | LYS155 |
| C | PHE156 |
| C | ILE158 |
| C | TYR246 |
| C | ASP276 |
| C | SER277 |
| C | GLY278 |
| C | THR279 |
| C | THR280 |
| C | ASN281 |
| C | ARG283 |
| C | SER373 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE77-VAL88 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
