3IVS
Homocitrate Synthase Lys4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004410 | molecular_function | homocitrate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009085 | biological_process | L-lysine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0019878 | biological_process | L-lysine biosynthetic process via aminoadipic acid |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004410 | molecular_function | homocitrate synthase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009085 | biological_process | L-lysine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0019878 | biological_process | L-lysine biosynthetic process via aminoadipic acid |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CO A 500 |
| Chain | Residue |
| A | GLU44 |
| A | HIS224 |
| A | HIS226 |
| A | HOH516 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 501 |
| Chain | Residue |
| A | HOH520 |
| A | GLU222 |
| A | HOH496 |
| A | HOH497 |
| A | HOH506 |
| A | HOH517 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CO B 500 |
| Chain | Residue |
| B | GLU44 |
| B | HIS224 |
| B | HIS226 |
| B | HOH528 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 501 |
| Chain | Residue |
| B | GLU222 |
| B | HOH496 |
| B | HOH503 |
| B | HOH513 |
| B | HOH523 |
| B | HOH524 |
Functional Information from PROSITE/UniProt
| site_id | PS00815 |
| Number of Residues | 17 |
| Details | AIPM_HOMOCIT_SYNTH_1 Alpha-isopropylmalate and homocitrate synthases signature 1. LREGeQfanaFfdtekK |
| Chain | Residue | Details |
| A | LEU42-LYS58 |
| site_id | PS00816 |
| Number of Residues | 14 |
| Details | AIPM_HOMOCIT_SYNTH_2 Alpha-isopropylmalate and homocitrate synthases signature 2. IecHfHNDtGmAiA |
| Chain | Residue | Details |
| A | ILE221-ALA234 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"O87198","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19776021","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IVU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19776021","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MI3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19776021","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3IVT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20089861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MI3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
