3IVS

Homocitrate Synthase Lys4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004410	molecular_function	homocitrate synthase activity
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0009085	biological_process	lysine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
A	0043436	biological_process	oxoacid metabolic process
A	0044283	biological_process	small molecule biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0003824	molecular_function	catalytic activity
B	0004410	molecular_function	homocitrate synthase activity
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0009085	biological_process	lysine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0019878	biological_process	lysine biosynthetic process via aminoadipic acid
B	0043436	biological_process	oxoacid metabolic process
B	0044283	biological_process	small molecule biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO A 500

Chain	Residue
A	GLU44
A	HIS224
A	HIS226
A	HOH516

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
A	HOH520
A	GLU222
A	HOH496
A	HOH497
A	HOH506
A	HOH517

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO B 500

Chain	Residue
B	GLU44
B	HIS224
B	HIS226
B	HOH528

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 501

Chain	Residue
B	GLU222
B	HOH496
B	HOH503
B	HOH513
B	HOH523
B	HOH524

---

Functional Information from PROSITE/UniProt

site_id	PS00815
Number of Residues	17
Details	AIPM_HOMOCIT_SYNTH_1 Alpha-isopropylmalate and homocitrate synthases signature 1. LREGeQfanaFfdtekK

Chain	Residue	Details
A	LEU42-LYS58

---

site_id	PS00816
Number of Residues	14
Details	AIPM_HOMOCIT_SYNTH_2 Alpha-isopropylmalate and homocitrate synthases signature 2. IecHfHNDtGmAiA

Chain	Residue	Details
A	ILE221-ALA234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:O87198

Chain	Residue	Details
A	HIS321
B	HIS321

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19776021, ECO:0007744|PDB:3IVT, ECO:0007744|PDB:3IVU

Chain	Residue	Details
A	ARG43
A	HIS103
A	ARG163
B	ARG43
B	HIS103
B	ARG163

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:19776021, ECO:0007744|PDB:3IVT, ECO:0007744|PDB:3MI3

Chain	Residue	Details
A	GLU44
A	HIS224
A	HIS226
B	GLU44
B	HIS224
B	HIS226

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20089861, ECO:0007744|PDB:3MI3

Chain	Residue	Details
A	ASP123
A	THR197
B	ASP123
B	THR197

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:19776021, ECO:0007744|PDB:3IVT

Chain	Residue	Details
A	SER165
B	SER165

---