Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 899 |
| Chain | Residue |
| A | ARG157 |
| A | ALA158 |
| A | ASN159 |
| A | GLU195 |
| A | GLN204 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 900 |
| Chain | Residue |
| A | ARG296 |
| A | HOH465 |
| A | GOL901 |
| A | 2LI1 |
| A | THR292 |
| A | THR293 |
| A | ASN294 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 901 |
| Chain | Residue |
| A | 2LI1 |
| A | GLY72 |
| A | GLN73 |
| A | GLY74 |
| A | GLY291 |
| A | THR293 |
| A | SO4900 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 2LI A 1 |
| Chain | Residue |
| A | HOH33 |
| A | LEU91 |
| A | ASP93 |
| A | GLY95 |
| A | SER96 |
| A | VAL130 |
| A | PRO131 |
| A | TYR132 |
| A | THR133 |
| A | PHE169 |
| A | TRP176 |
| A | TYR259 |
| A | LYS285 |
| A | ILE287 |
| A | ASP289 |
| A | GLY291 |
| A | THR292 |
| A | THR390 |
| A | VAL393 |
| A | SO4900 |
| A | GOL901 |
| B | ASN223 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 899 |
| Chain | Residue |
| B | THR143 |
| B | ARG157 |
| B | ASN159 |
| B | GLU195 |
| B | SER200 |
| B | GLN204 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 900 |
| Chain | Residue |
| B | 2LI2 |
| B | THR292 |
| B | THR293 |
| B | ASN294 |
| B | HOH468 |
| B | GOL901 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 901 |
| Chain | Residue |
| B | 2LI2 |
| B | GLY72 |
| B | GLN73 |
| B | GLY74 |
| B | ILE171 |
| B | GLY291 |
| B | THR293 |
| B | HOH483 |
| B | SO4900 |
| site_id | AC8 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 2LI B 2 |
| Chain | Residue |
| B | HOH11 |
| B | LEU91 |
| B | ASP93 |
| B | GLY95 |
| B | SER96 |
| B | VAL130 |
| B | PRO131 |
| B | TYR132 |
| B | THR133 |
| B | GLY135 |
| B | PHE169 |
| B | TRP176 |
| B | TYR259 |
| B | LYS285 |
| B | ILE287 |
| B | ASP289 |
| B | GLY291 |
| B | THR292 |
| B | THR390 |
| B | VAL393 |
| B | SO4900 |
| B | GOL901 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 899 |
| Chain | Residue |
| C | ARG157 |
| C | GLU195 |
| C | SER200 |
| C | GLN204 |
| C | HOH501 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 900 |
| Chain | Residue |
| C | 2LI3 |
| C | HOH45 |
| C | THR292 |
| C | THR293 |
| C | ASN294 |
| C | GOL901 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 901 |
| Chain | Residue |
| C | GLY291 |
| C | THR293 |
| C | SO4900 |
| C | 2LI3 |
| C | GLY72 |
| C | GLY74 |
| C | ILE171 |
| site_id | BC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 2LI C 3 |
| Chain | Residue |
| C | HOH39 |
| C | LEU91 |
| C | ASP93 |
| C | GLY95 |
| C | SER96 |
| C | PRO131 |
| C | TYR132 |
| C | THR133 |
| C | PHE169 |
| C | TRP176 |
| C | TYR259 |
| C | LYS285 |
| C | ILE287 |
| C | ASP289 |
| C | GLY291 |
| C | THR292 |
| C | THR390 |
| C | SO4900 |
| C | GOL901 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | THR292 | |
| A | ASP289 | |
| A | SER96 | |
| A | ASP93 | |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP289 | |
| A | SER96 | |
| A | ASP93 | |
| A | TYR132 | |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP289 | |
| B | SER96 | |
| B | ASP93 | |
| B | TYR132 | |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | ASP289 | |
| C | SER96 | |
| C | ASP93 | |
| C | TYR132 | |
| site_id | CSA13 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | THR292 | |
| A | ASP289 | |
| A | ASP93 | |
| A | THR94 | |
| site_id | CSA14 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | THR292 | |
| B | ASP289 | |
| B | ASP93 | |
| B | THR94 | |
| site_id | CSA15 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | THR292 | |
| C | ASP289 | |
| C | ASP93 | |
| C | THR94 | |
| site_id | CSA16 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP93 | |
| site_id | CSA17 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP93 | |
| site_id | CSA18 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | ASP93 | |
| site_id | CSA19 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP289 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | THR292 | |
| B | ASP289 | |
| B | SER96 | |
| B | ASP93 | |
| site_id | CSA20 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP289 | |
| site_id | CSA21 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | ASP289 | |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | THR292 | |
| C | ASP289 | |
| C | SER96 | |
| C | ASP93 | |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP289 | |
| A | SER290 | |
| A | ASP93 | |
| A | THR94 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP289 | |
| B | SER290 | |
| B | ASP93 | |
| B | THR94 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | ASP289 | |
| C | SER290 | |
| C | ASP93 | |
| C | THR94 | |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| A | ASP289 | |
| A | SER96 | |
| A | ASP93 | |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| B | ASP289 | |
| B | SER96 | |
| B | ASP93 | |
| site_id | CSA9 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1am5 |
| Chain | Residue | Details |
| C | ASP289 | |
| C | SER96 | |
| C | ASP93 | |
