3IV9
Structure of the B12-dependent Methionine Synthase (MetH) C-teminal half in a "His-On" conformation
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE B12 A 1301 |
| Chain | Residue |
| A | VAL758 |
| A | LEU806 |
| A | ILE807 |
| A | THR808 |
| A | GLY833 |
| A | GLY834 |
| A | ALA835 |
| A | THR836 |
| A | VAL857 |
| A | GLN858 |
| A | ASN859 |
| A | HIS759 |
| A | ALA860 |
| A | ASP1093 |
| A | ALA1136 |
| A | PRO1137 |
| A | GLY1138 |
| A | TYR1139 |
| A | HIS1145 |
| A | LYS1148 |
| A | MET1171 |
| A | GLY1174 |
| A | ASP760 |
| A | ALA1175 |
| A | SER1176 |
| A | VAL1177 |
| A | SER1178 |
| A | HOH1400 |
| A | ILE761 |
| A | GLY762 |
| A | ILE765 |
| A | VAL766 |
| A | GLY802 |
| A | SER804 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 135 |
| Details | Domain: {"description":"B12-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00666","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 330 |
| Details | Domain: {"description":"AdoMet activation","evidences":[{"source":"PROSITE-ProRule","id":"PRU00346","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7992050","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BMT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"7992050","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BMT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8939751","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| A | SER810 | |
| A | ASP757 | |
| A | HIS759 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| A | LEU770 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 268 |
| Chain | Residue | Details |
| A | ASP757 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | HIS759 | hydrogen bond acceptor, hydrogen bond donor, increase electrophilicity, increase nucleophilicity, metal ligand, proton acceptor, proton donor |
| A | SER810 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
