3ITJ

Crystal structure of Saccharomyces cerevisiae thioredoxin reductase 1 (Trr1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0008198	molecular_function	ferrous iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0034599	biological_process	cellular response to oxidative stress
A	0045454	biological_process	cell redox homeostasis
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0008198	molecular_function	ferrous iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0034599	biological_process	cellular response to oxidative stress
B	0045454	biological_process	cell redox homeostasis
C	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0008198	molecular_function	ferrous iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0034599	biological_process	cellular response to oxidative stress
C	0045454	biological_process	cell redox homeostasis
D	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0008198	molecular_function	ferrous iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0034599	biological_process	cellular response to oxidative stress
D	0045454	biological_process	cell redox homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD A 400

Chain	Residue
A	ILE8
A	ALA36
A	ASN37
A	ILE39
A	ALA40
A	GLY43
A	GLN44
A	LEU45
A	THR48
A	ILE51
A	ASN53
A	GLY9
A	THR85
A	VAL86
A	THR118
A	GLY119
A	TRP134
A	CYS144
A	GLY286
A	ASP287
A	ARG294
A	GLN295
A	SER10
A	ALA296
A	SER299
A	HOH323
A	HOH328
A	HOH332
A	HOH335
A	HOH337
A	HOH352
A	HOH377
D	TYR20
A	GLY11
A	PRO12
A	ALA13
A	TYR31
A	GLU32
A	GLY33

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CIT A 501

Chain	Residue
A	ASP163
A	SER164
A	ARG189
A	GLY248
A	HIS249
A	HOH386

---

site_id	AC3
Number of Residues	39
Details	BINDING SITE FOR RESIDUE FAD B 401

Chain	Residue
B	ILE8
B	GLY9
B	SER10
B	GLY11
B	PRO12
B	ALA13
B	TYR31
B	GLU32
B	GLY33
B	ALA36
B	ASN37
B	ILE39
B	ALA40
B	GLY43
B	GLN44
B	LEU45
B	THR48
B	ILE51
B	ASN53
B	GLU84
B	THR85
B	VAL86
B	THR118
B	GLY119
B	TRP134
B	GLN135
B	CYS144
B	GLY286
B	ASP287
B	ARG294
B	GLN295
B	ALA296
B	SER299
B	HOH323
B	HOH326
B	HOH327
B	HOH329
B	HOH334
C	TYR20

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CIT B 502

Chain	Residue
B	GLY160
B	GLY161
B	ARG184
B	LYS185
B	ARG189
B	ILE247
B	HOH341
B	HOH355
B	HOH356
B	HOH358
B	HOH391

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT B 506

Chain	Residue
B	HIS249
B	HOH325
B	HOH380
B	ASP163
B	SER164
B	ARG189
B	GLY248

---

site_id	AC6
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD C 402

Chain	Residue
B	TYR20
C	ILE8
C	GLY9
C	SER10
C	GLY11
C	PRO12
C	ALA13
C	TYR31
C	GLU32
C	GLY33
C	ALA36
C	ILE39
C	ALA40
C	GLY43
C	GLN44
C	LEU45
C	THR48
C	ILE51
C	ASN53
C	GLU84
C	THR85
C	VAL86
C	THR118
C	GLY119
C	CYS141
C	CYS144
C	GLY286
C	ASP287
C	ARG294
C	GLN295
C	ALA296
C	SER299
C	HOH325
C	HOH326
C	HOH331
C	HOH332
C	HOH333
C	HOH337

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CIT C 503

Chain	Residue
A	GLU234
C	MET125
C	GLY161
C	ARG184
C	ARG189
C	ILE247
C	HOH366

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CIT C 505

Chain	Residue
C	GLY162
C	ASP163
C	SER164
C	ARG189
C	GLY248
C	HIS249
C	ARG294
C	HOH371
C	HOH380

---

site_id	AC9
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD D 403

Chain	Residue
A	TYR20
D	ILE8
D	GLY9
D	SER10
D	GLY11
D	PRO12
D	ALA13
D	TYR31
D	GLU32
D	GLY33
D	ALA36
D	ASN37
D	ILE39
D	ALA40
D	GLY43
D	GLN44
D	THR48
D	ILE51
D	ASN53
D	GLU84
D	THR85
D	VAL86
D	ALA117
D	THR118
D	GLY119
D	ALA140
D	ILE255
D	GLY286
D	ASP287
D	ARG294
D	GLN295
D	ALA296
D	SER299
D	HOH324
D	HOH334
D	HOH336
D	HOH339
D	HOH341

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CIT D 504

Chain	Residue
C	LYS232
D	ARG184
D	ILE247
D	HOH352
D	HOH357

---

Functional Information from PROSITE/UniProt

site_id	PS00573
Number of Residues	23
Details	PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CavCDGavpiFrnkpLaVIGGGD

Chain	Residue	Details
A	CYS141-ASP163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18930846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20235561","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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