Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
| C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019430 | biological_process | removal of superoxide radicals |
| C | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE FAD A 348 |
| Chain | Residue |
| A | GLY8 |
| A | ILE46 |
| A | ASN48 |
| A | VAL81 |
| A | ALA109 |
| A | THR110 |
| A | GLY111 |
| A | GLY112 |
| A | THR132 |
| A | CYS136 |
| A | GLY280 |
| A | GLY10 |
| A | ASP281 |
| A | LYS288 |
| A | GLN289 |
| A | VAL290 |
| A | ALA293 |
| A | HOH313 |
| A | HOH315 |
| A | HOH316 |
| A | HOH397 |
| A | HOH449 |
| A | PRO11 |
| A | HOH454 |
| A | HOH538 |
| A | ALA12 |
| A | GLU32 |
| A | LYS33 |
| A | GLY38 |
| A | GLN39 |
| A | ILE40 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 348 |
| Chain | Residue |
| B | GLY8 |
| B | GLY9 |
| B | GLY10 |
| B | PRO11 |
| B | ALA12 |
| B | GLU32 |
| B | LYS33 |
| B | GLY38 |
| B | GLN39 |
| B | ILE40 |
| B | SER43 |
| B | ILE46 |
| B | ASN48 |
| B | THR79 |
| B | VAL81 |
| B | ALA109 |
| B | THR110 |
| B | GLY111 |
| B | CYS136 |
| B | ASN242 |
| B | GLY280 |
| B | ASP281 |
| B | LYS288 |
| B | GLN289 |
| B | VAL290 |
| B | ALA293 |
| B | HOH316 |
| B | HOH317 |
| B | HOH357 |
| B | HOH365 |
| B | HOH388 |
| B | HOH410 |
| B | HOH454 |
| B | HOH540 |
| B | HOH556 |
| site_id | AC3 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD C 348 |
| Chain | Residue |
| C | HOH356 |
| C | HOH481 |
| C | HOH526 |
| C | GLY8 |
| C | GLY9 |
| C | GLY10 |
| C | PRO11 |
| C | ALA12 |
| C | GLU32 |
| C | LYS33 |
| C | GLY38 |
| C | GLN39 |
| C | ILE40 |
| C | SER43 |
| C | ILE46 |
| C | ASN48 |
| C | THR79 |
| C | ALA80 |
| C | VAL81 |
| C | ALA109 |
| C | THR110 |
| C | GLY111 |
| C | GLY112 |
| C | CYS136 |
| C | ASN242 |
| C | GLY280 |
| C | ASP281 |
| C | LYS288 |
| C | GLN289 |
| C | VAL290 |
| C | ALA293 |
| C | HOH313 |
| C | HOH319 |
| C | HOH323 |
| C | HOH332 |
| C | HOH339 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YknkeVaVLGGGD |
| Chain | Residue | Details |
| A | CYS133-ASP153 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A9P4","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| A | CYS136 | |
| A | CYS133 | |
| A | ASP137 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| B | CYS136 | |
| B | CYS133 | |
| B | ASP137 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| C | CYS136 | |
| C | CYS133 | |
| C | ASP137 | |
