3IQF
Structure of F420 dependent methylene-tetrahydromethanopterin dehydrogenase in complex with methenyl-tetrahydromethanopterin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| A | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| B | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| C | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| D | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| E | 0006730 | biological_process | one-carbon metabolic process |
| E | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| E | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| F | 0006730 | biological_process | one-carbon metabolic process |
| F | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| F | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| G | 0006730 | biological_process | one-carbon metabolic process |
| G | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| G | 0015948 | biological_process | methanogenesis |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| G | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| H | 0006730 | biological_process | one-carbon metabolic process |
| H | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| H | 0015948 | biological_process | methanogenesis |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| H | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| I | 0006730 | biological_process | one-carbon metabolic process |
| I | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| I | 0015948 | biological_process | methanogenesis |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| I | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| J | 0006730 | biological_process | one-carbon metabolic process |
| J | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| J | 0015948 | biological_process | methanogenesis |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| J | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| K | 0006730 | biological_process | one-carbon metabolic process |
| K | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| K | 0015948 | biological_process | methanogenesis |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| K | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
| L | 0006730 | biological_process | one-carbon metabolic process |
| L | 0008901 | molecular_function | ferredoxin hydrogenase activity |
| L | 0015948 | biological_process | methanogenesis |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| L | 0030268 | molecular_function | methylenetetrahydromethanopterin dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE E4M A 284 |
| Chain | Residue |
| A | ASN13 |
| A | GLU130 |
| A | ASN141 |
| A | LEU144 |
| A | CYS221 |
| A | TYR230 |
| A | HOH440 |
| D | GLU26 |
| D | ARG27 |
| D | ALA28 |
| A | LEU14 |
| A | GLY15 |
| A | VAL42 |
| A | MET124 |
| A | LEU125 |
| A | ALA127 |
| A | ARG128 |
| A | ARG129 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E4M B 284 |
| Chain | Residue |
| B | ASN13 |
| B | GLY15 |
| B | VAL42 |
| B | MET124 |
| B | LEU125 |
| B | ALA127 |
| B | ARG128 |
| B | ARG129 |
| B | GLU130 |
| B | ASN141 |
| B | LEU144 |
| B | CYS221 |
| B | TYR230 |
| B | HOH304 |
| B | HOH576 |
| B | HOH769 |
| B | HOH1248 |
| F | GLU26 |
| F | ARG27 |
| F | ALA28 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E4M C 284 |
| Chain | Residue |
| C | ASN13 |
| C | GLY15 |
| C | VAL42 |
| C | MET124 |
| C | LEU125 |
| C | ALA127 |
| C | ARG128 |
| C | ARG129 |
| C | GLU130 |
| C | MET137 |
| C | ASN141 |
| C | LEU144 |
| C | CYS221 |
| C | TYR230 |
| C | HOH286 |
| C | HOH299 |
| C | HOH1047 |
| E | GLU26 |
| E | ARG27 |
| E | ALA28 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE E4M D 284 |
| Chain | Residue |
| A | GLU26 |
| A | ARG27 |
| A | ALA28 |
| D | ASN13 |
| D | GLY15 |
| D | VAL42 |
| D | MET124 |
| D | LEU125 |
| D | ALA127 |
| D | ARG128 |
| D | ARG129 |
| D | GLU130 |
| D | ASN141 |
| D | LEU144 |
| D | CYS221 |
| D | TYR230 |
| D | HOH296 |
| D | HOH777 |
| D | HOH1172 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E4M E 284 |
| Chain | Residue |
| C | GLU26 |
| C | ARG27 |
| C | ALA28 |
| C | HOH306 |
| E | ASN13 |
| E | GLY15 |
| E | VAL42 |
| E | MET124 |
| E | LEU125 |
| E | ALA127 |
| E | ARG128 |
| E | ARG129 |
| E | GLU130 |
| E | ASN141 |
| E | LEU144 |
| E | CYS221 |
| E | TYR230 |
| E | HOH305 |
| E | HOH358 |
| E | HOH578 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA E 285 |
| Chain | Residue |
| E | GLU47 |
| E | GLU50 |
| B | GLU85 |
| B | ASP89 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE E4M F 284 |
| Chain | Residue |
| B | GLU26 |
| B | ARG27 |
| B | ALA28 |
| B | HOH822 |
| F | ASN13 |
| F | GLY15 |
| F | VAL42 |
| F | MET124 |
| F | LEU125 |
| F | ALA127 |
| F | ARG128 |
| F | ARG129 |
| F | GLU130 |
| F | ASN141 |
| F | CYS221 |
| F | TYR230 |
| F | HOH286 |
| F | HOH1100 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA F 285 |
| Chain | Residue |
| F | HOH1159 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E4M G 284 |
| Chain | Residue |
| G | ASN13 |
| G | GLY15 |
| G | VAL42 |
| G | MET124 |
| G | LEU125 |
| G | ALA127 |
| G | ARG128 |
| G | ARG129 |
| G | GLU130 |
| G | ASN141 |
| G | LEU144 |
| G | CYS221 |
| G | TYR230 |
| G | HOH294 |
| G | HOH303 |
| G | HOH417 |
| G | HOH947 |
| J | GLU26 |
| J | ARG27 |
| J | ALA28 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE E4M H 284 |
| Chain | Residue |
| H | ASN13 |
| H | GLY15 |
| H | MET124 |
| H | LEU125 |
| H | ALA127 |
| H | ARG128 |
| H | ARG129 |
| H | GLU130 |
| H | ASN141 |
| H | LEU144 |
| H | CYS221 |
| H | TYR230 |
| H | HOH306 |
| H | HOH310 |
| H | HOH735 |
| H | HOH1237 |
| L | GLU26 |
| L | ARG27 |
| site_id | BC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE E4M I 284 |
| Chain | Residue |
| I | ASN13 |
| I | GLY15 |
| I | VAL42 |
| I | MET124 |
| I | LEU125 |
| I | ALA127 |
| I | ARG128 |
| I | ARG129 |
| I | GLU130 |
| I | MET137 |
| I | ASN141 |
| I | LEU144 |
| I | CYS221 |
| I | TYR230 |
| I | HOH306 |
| I | HOH529 |
| I | HOH764 |
| I | HOH1225 |
| K | GLU26 |
| K | ARG27 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA I 285 |
| Chain | Residue |
| I | ARG129 |
| I | GLU130 |
| I | PHE131 |
| I | LEU132 |
| I | ASP133 |
| K | ARG263 |
| K | PRO265 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE E4M J 284 |
| Chain | Residue |
| G | GLU26 |
| G | ARG27 |
| J | ASN13 |
| J | GLY15 |
| J | MET124 |
| J | LEU125 |
| J | ALA127 |
| J | ARG128 |
| J | ARG129 |
| J | GLU130 |
| J | ASN141 |
| J | LEU144 |
| J | CYS221 |
| J | TYR230 |
| J | HOH298 |
| J | HOH661 |
| J | HOH684 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA J 285 |
| Chain | Residue |
| J | SER257 |
| J | ASN258 |
| K | SER257 |
| K | ASN258 |
| L | SER257 |
| L | ASN258 |
| site_id | BC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE E4M K 284 |
| Chain | Residue |
| I | GLU26 |
| I | ARG27 |
| I | ALA28 |
| K | ASN13 |
| K | GLY15 |
| K | VAL42 |
| K | MET124 |
| K | LEU125 |
| K | ALA127 |
| K | ARG128 |
| K | ARG129 |
| K | GLU130 |
| K | ASN141 |
| K | LEU144 |
| K | CYS221 |
| K | TYR230 |
| K | HOH295 |
| K | HOH430 |
| K | HOH783 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA K 285 |
| Chain | Residue |
| H | GLU47 |
| H | GLU50 |
| K | GLU85 |
| K | ASP89 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA K 286 |
| Chain | Residue |
| K | ASP259 |
| K | ALA260 |
| K | VAL261 |
| K | ARG276 |
| K | PHE278 |
| L | TYR198 |
| site_id | BC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE E4M L 284 |
| Chain | Residue |
| H | GLU26 |
| H | ARG27 |
| H | HOH305 |
| L | ASN13 |
| L | GLY15 |
| L | VAL42 |
| L | MET124 |
| L | LEU125 |
| L | ALA127 |
| L | ARG128 |
| L | ARG129 |
| L | GLU130 |
| L | ASN141 |
| L | LEU144 |
| L | CYS221 |
| L | TYR230 |
| L | HOH293 |
| L | HOH808 |
| L | HOH817 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA L 285 |
| Chain | Residue |
| J | TYR198 |
| L | ASP259 |
| L | ALA260 |
| L | VAL261 |
| L | ARG276 |
| L | PHE278 |
| L | HOH1218 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 336 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
