Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005764 | cellular_component | lysosome |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE E64 A 301 |
| Chain | Residue |
| A | GLN19 |
| A | GLY65 |
| A | GLY66 |
| A | PRO68 |
| A | VAL133 |
| A | ASP158 |
| A | HIS159 |
| A | ARG213 |
| A | HOH268 |
| A | HOH308 |
| A | HOH356 |
| A | GLY23 |
| A | SO4406 |
| A | HOH430 |
| A | EDO506 |
| A | SER24 |
| A | CYS25 |
| A | TRP26 |
| A | THR42 |
| A | GLY43 |
| A | TYR61 |
| A | ARG64 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | PRO15 |
| A | PRO15 |
| A | ARG17 |
| A | ARG17 |
| A | SER47 |
| A | SER47 |
| A | ARG83 |
| A | ARG83 |
| A | HOH261 |
| A | HOH261 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | ASN18 |
| A | TYR85 |
| A | PRO103 |
| A | GLY178 |
| A | THR179 |
| A | GLY180 |
| A | HOH254 |
| A | HOH274 |
| A | HOH309 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | ARG93 |
| A | GLN94 |
| A | ARG96 |
| A | ASP169 |
| A | LYS190 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | CYS56 |
| A | GLU57 |
| A | ARG58 |
| A | ARG59 |
| A | TYR74 |
| A | ARG145 |
| A | HOH300 |
| A | HOH316 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | ARG83 |
| A | ARG83 |
| A | PRO87 |
| A | TYR88 |
| A | EDO510 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 406 |
| Chain | Residue |
| A | ARG8 |
| A | TYR61 |
| A | ARG64 |
| A | GLU183 |
| A | ARG188 |
| A | HOH243 |
| A | HOH264 |
| A | E64301 |
| A | HOH328 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 407 |
| Chain | Residue |
| A | PHE67 |
| A | PRO68 |
| A | LEU69 |
| A | ASP205 |
| A | HOH266 |
| A | HOH332 |
| A | HOH338 |
| A | HOH364 |
| A | HOH375 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 408 |
| Chain | Residue |
| A | ARG124 |
| A | ILE127 |
| A | SER156 |
| A | HOH319 |
| A | HOH367 |
| A | HOH390 |
| A | HOH393 |
| A | EDO503 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 501 |
| Chain | Residue |
| A | TYR85 |
| A | TYR86 |
| A | PRO87 |
| A | ARG96 |
| A | GLN99 |
| A | ALA100 |
| A | HOH283 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 502 |
| Chain | Residue |
| A | ARG58 |
| A | ARG145 |
| A | HOH423 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 503 |
| Chain | Residue |
| A | HOH246 |
| A | SO4408 |
| A | ILE37 |
| A | ILE127 |
| A | SER156 |
| A | ARG213 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 504 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 505 |
| Chain | Residue |
| A | GLU135 |
| A | LYS137 |
| A | SER156 |
| A | ASP158 |
| A | ARG213 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 506 |
| Chain | Residue |
| A | GLY21 |
| A | GLY23 |
| A | E64301 |
| A | HOH327 |
| A | EDO507 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 507 |
| Chain | Residue |
| A | TRP177 |
| A | EDO506 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 509 |
| Chain | Residue |
| A | GLN44 |
| A | LEU46 |
| A | PRO103 |
| A | THR179 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 510 |
| Chain | Residue |
| A | ARG17 |
| A | GLU50 |
| A | ARG83 |
| A | ARG83 |
| A | HOH285 |
| A | HOH298 |
| A | SO4405 |
| A | HOH424 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGgCGSCWTfSS |
| Chain | Residue | Details |
| A | GLN19-SER30 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. IDHAVAAVGYG |
| Chain | Residue | Details |
| A | ILE157-GLY167 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YILiKNSWgtgWGegGYIrI |
| Chain | Residue | Details |
| A | TYR170-ILE189 | |
