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3INK

UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY

Functional Information from GO Data
ChainGOidnamespacecontents
C0002250biological_processadaptive immune response
C0002366biological_processleukocyte activation involved in immune response
C0002376biological_processimmune system process
C0002639biological_processpositive regulation of immunoglobulin production
C0002903biological_processnegative regulation of B cell apoptotic process
C0005125molecular_functioncytokine activity
C0005134molecular_functioninterleukin-2 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006955biological_processimmune response
C0007155biological_processcell adhesion
C0007186biological_processG protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0007267biological_processcell-cell signaling
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0019209molecular_functionkinase activator activity
C0030101biological_processnatural killer cell activation
C0030217biological_processT cell differentiation
C0030246molecular_functioncarbohydrate binding
C0030307biological_processpositive regulation of cell growth
C0030890biological_processpositive regulation of B cell proliferation
C0031851molecular_functionkappa-type opioid receptor binding
C0032740biological_processpositive regulation of interleukin-17 production
C0034105biological_processpositive regulation of tissue remodeling
C0038110biological_processinterleukin-2-mediated signaling pathway
C0042102biological_processpositive regulation of T cell proliferation
C0042104biological_processpositive regulation of activated T cell proliferation
C0043066biological_processnegative regulation of apoptotic process
C0043208molecular_functionglycosphingolipid binding
C0045471biological_processresponse to ethanol
C0045582biological_processpositive regulation of T cell differentiation
C0045591biological_processpositive regulation of regulatory T cell differentiation
C0045621biological_processpositive regulation of lymphocyte differentiation
C0050729biological_processpositive regulation of inflammatory response
C0060999biological_processpositive regulation of dendritic spine development
C0070665biological_processpositive regulation of leukocyte proliferation
C0097696biological_processcell surface receptor signaling pathway via STAT
C1900100biological_processpositive regulation of plasma cell differentiation
C1901327biological_processresponse to tacrolimus
C1902107biological_processpositive regulation of leukocyte differentiation
C2000320biological_processnegative regulation of T-helper 17 cell differentiation
D0002250biological_processadaptive immune response
D0002366biological_processleukocyte activation involved in immune response
D0002376biological_processimmune system process
D0002639biological_processpositive regulation of immunoglobulin production
D0002903biological_processnegative regulation of B cell apoptotic process
D0005125molecular_functioncytokine activity
D0005134molecular_functioninterleukin-2 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006955biological_processimmune response
D0007155biological_processcell adhesion
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0007267biological_processcell-cell signaling
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0019209molecular_functionkinase activator activity
D0030101biological_processnatural killer cell activation
D0030217biological_processT cell differentiation
D0030246molecular_functioncarbohydrate binding
D0030307biological_processpositive regulation of cell growth
D0030890biological_processpositive regulation of B cell proliferation
D0031851molecular_functionkappa-type opioid receptor binding
D0032740biological_processpositive regulation of interleukin-17 production
D0034105biological_processpositive regulation of tissue remodeling
D0038110biological_processinterleukin-2-mediated signaling pathway
D0042102biological_processpositive regulation of T cell proliferation
D0042104biological_processpositive regulation of activated T cell proliferation
D0043066biological_processnegative regulation of apoptotic process
D0043208molecular_functionglycosphingolipid binding
D0045471biological_processresponse to ethanol
D0045582biological_processpositive regulation of T cell differentiation
D0045591biological_processpositive regulation of regulatory T cell differentiation
D0045621biological_processpositive regulation of lymphocyte differentiation
D0050729biological_processpositive regulation of inflammatory response
D0060999biological_processpositive regulation of dendritic spine development
D0070665biological_processpositive regulation of leukocyte proliferation
D0097696biological_processcell surface receptor signaling pathway via STAT
D1900100biological_processpositive regulation of plasma cell differentiation
D1901327biological_processresponse to tacrolimus
D1902107biological_processpositive regulation of leukocyte differentiation
D2000320biological_processnegative regulation of T-helper 17 cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
CTHR51-LEU63

246704

PDB entries from 2025-12-24

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