3IMJ
Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE AYI A 1 |
| Chain | Residue |
| A | HOH30 |
| A | LYS109 |
| A | LEU120 |
| A | TRP121 |
| A | HOH218 |
| A | HOH231 |
| A | ARG67 |
| A | ARG86 |
| A | SER88 |
| A | SER90 |
| A | SER96 |
| A | GLN106 |
| A | HIS107 |
| A | PHE108 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AYI B 1 |
| Chain | Residue |
| A | PRO155 |
| B | HOH46 |
| B | ARG67 |
| B | ARG86 |
| B | SER88 |
| B | GLU89 |
| B | SER90 |
| B | SER96 |
| B | GLN106 |
| B | HIS107 |
| B | PHE108 |
| B | LYS109 |
| B | LEU111 |
| B | LEU120 |
| B | TRP121 |
| B | HOH192 |
| B | HOH204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS109 | |
| B | LYS109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34348893 |
| Chain | Residue | Details |
| A | LYS109 | |
| B | LYS109 |
