3IMD
Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FYQ A 1 |
| Chain | Residue |
| A | ARG67 |
| A | TRP121 |
| A | HOH171 |
| A | HOH177 |
| A | HOH178 |
| A | HOH186 |
| A | HOH187 |
| B | ARG78 |
| B | VAL154 |
| B | PRO155 |
| B | HOH207 |
| A | ARG86 |
| A | SER88 |
| A | SER90 |
| A | SER96 |
| A | HIS107 |
| A | PHE108 |
| A | LYS109 |
| A | LEU120 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 2 |
| Chain | Residue |
| A | SER139 |
| A | GLN145 |
| A | HOH195 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 4 |
| Chain | Residue |
| A | HIS58 |
| A | ASN129 |
| A | ASP133 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 5 |
| Chain | Residue |
| A | ARG78 |
| A | GLU152 |
| B | LYS109 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 6 |
| Chain | Residue |
| A | LYS109 |
| B | ARG78 |
| B | GLU152 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE FYQ B 1 |
| Chain | Residue |
| A | ARG78 |
| A | GLU152 |
| A | VAL154 |
| A | PRO155 |
| B | HOH5 |
| B | HOH7 |
| B | HOH8 |
| B | HOH13 |
| B | HOH27 |
| B | ARG67 |
| B | ARG86 |
| B | SER88 |
| B | SER90 |
| B | SER96 |
| B | HIS107 |
| B | PHE108 |
| B | LYS109 |
| B | LEU120 |
| B | TRP121 |
| B | HOH196 |
| B | HOH206 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 170 |
| Chain | Residue |
| B | SER139 |
| B | GLN145 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
