3ILT

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 400

Chain	Residue
B	TYR61
B	GLU193
B	TYR220
B	HOH266
B	HOH269
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	LEU138
B	GLY141
B	SER142
B	THR143

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU E 400

Chain	Residue
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	GLY141
E	SER142
E	THR143
E	GLU193
E	TYR220
E	HOH263
E	HOH280

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU H 400

Chain	Residue
H	TYR61
H	PRO89
H	LEU90
H	THR91
H	ARG96
H	LEU138
H	GLY141
H	SER142
H	THR143
H	GLU193
H	TYR220
H	HOH268
H	HOH271
H	HOH302

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1

Chain	Residue
B	GLU42
B	HIS46
B	HOH262
H	GLU166

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	HIS23
E	ASP65
E	ALA66

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 262

Chain	Residue
E	GLU42
E	HIS46

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 3

Chain	Residue
E	HIS23
H	LYS20
H	HIS23
H	GLU30

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 262

Chain	Residue
B	GLU166
H	GLU42
H	HIS46
H	GLN244

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE TRU B 800

Chain	Residue
B	LYS104
B	PRO105
B	PHE106
B	SER108
B	LEU239
B	SER242
B	LEU247
B	ASP248
B	LYS251
B	HOH294
E	SER217
E	LYS218
E	HOH296

---

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE TRU E 800

Chain	Residue
B	SER217
B	LYS218
E	PRO105
E	PHE106
E	MET107
E	SER108
E	LEU239
E	SER242
E	LEU247
E	ASP248
E	LYS251
E	HOH264

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE TRU H 800

Chain	Residue
H	PRO105
H	PHE106
H	MET107
H	SER108
H	SER217
H	LYS218
H	VAL238
H	LEU239
H	SER242
H	LEU247
H	ASP248
H	LYS251
H	HOH269
H	HOH286

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
B	PRO89
E	SER142
E	THR143
E	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
B	THR91
B	ARG96
B	SER142
B	THR143
B	GLU193
E	PRO89
E	THR91
E	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
E	ARG64
E	ARG148
E	LYS240
H	ARG64
H	ARG148
H	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
E	ILE121
H	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
E	SER150
H	SER150

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
E	SER184
H	SER184

---