3IL1

Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 400

Chain	Residue
B	TYR61
B	TYR220
B	HOH269
B	HOH287
B	HOH289
B	PRO89
B	LEU90
B	THR91
B	ARG96
B	GLY141
B	SER142
B	THR143
B	GLU193

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GLU E 400

Chain	Residue
E	TYR61
E	PRO89
E	LEU90
E	THR91
E	ARG96
E	LEU138
E	GLY141
E	SER142
E	THR143
E	GLU193
E	TYR220
E	HOH264
E	HOH267
E	HOH339

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLU H 400

Chain	Residue
H	TYR61
H	PRO89
H	LEU90
H	THR91
H	ARG96
H	GLY141
H	SER142
H	THR143
H	GLU193
H	HOH270
H	HOH287
H	HOH296

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN B 263

Chain	Residue
B	GLU42
B	HIS46
H	GLU166

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	GLU42
E	HIS46

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN E 262

Chain	Residue
B	HIS23
E	ASP65
E	HOH743

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 2

Chain	Residue
E	HIS23
E	GLU24
H	HIS23
H	GLU30

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN H 3

Chain	Residue
B	GLU166
H	GLU42
H	HIS46
H	LEU241
H	GLN244

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE B5D B 801

Chain	Residue
B	LYS104
B	PRO105
B	VAL238
B	SER242
B	B5D262
E	ILE92
E	PRO105
E	SER108
E	LYS218
E	GLY219

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE B5D B 262

Chain	Residue
B	ILE92
B	SER108
B	SER217
B	LYS218
B	GLY219
B	B5D801
E	LYS104
E	PRO105
E	VAL238
E	SER242
E	HOH610

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE B5D H 801

Chain	Residue
H	ILE92
H	PRO105
H	PRO105
H	SER108
H	LYS218
H	GLY219
H	VAL238
H	LEU239
H	SER242

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:16483599

Chain	Residue	Details
B	TYR61
B	ARG96
B	GLU193
E	TYR61
E	ARG96
E	GLU193
H	TYR61
H	ARG96
H	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
B	PRO89
E	PRO89
H	PRO89

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	THR91
B	SER142
B	THR143
E	THR91
E	SER142
E	THR143
H	THR91
H	SER142
H	THR143

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ARG64
B	ARG148
B	LYS240
E	ARG64
E	ARG148
E	LYS240
H	ARG64
H	ARG148
H	LYS240

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
B	ILE121
E	ILE121
H	ILE121

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER150
E	SER150
H	SER150

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
B	SER184
E	SER184
H	SER184

---