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3IJ4

Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005272molecular_functionsodium channel activity
A0006814biological_processsodium ion transport
A0015280molecular_functionligand-gated sodium channel activity
A0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 1
ChainResidue
ALYS212
AARG310
AGLU314

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CS A 467
ChainResidue
ATHR237
ATHR240

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CS A 468
ChainResidue
AGLU299
ATYR301

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CS A 469
ChainResidue
AASP433
ACS470
ACS470
ACS470
AASP433
AASP433

site_idAC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE CS A 470
ChainResidue
AGLY432
AGLY432
AGLY432
AASP433
AASP433
AASP433
ACS469
ACS469
ACS469

Functional Information from PROSITE/UniProt
site_idPS01206
Number of Residues21
DetailsASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC
ChainResidueDetails
ATYR304-CYS324

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues23
DetailsTRANSMEM: Helical
ChainResidueDetails
ATRP47-PHE70

site_idSWS_FT_FI2
Number of Residues355
DetailsTOPO_DOM: Extracellular
ChainResidueDetails
ALEU71-GLU426

site_idSWS_FT_FI3
Number of Residues26
DetailsTRANSMEM: Discontinuously helical
ChainResidueDetails
AVAL427-PHE453

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for channel gating
ChainResidueDetails
ATYR72
ATRP288

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Important for channel desensitizing
ChainResidueDetails
AGLU80

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900
ChainResidueDetails
AASN367
AASN394

227344

PDB entries from 2024-11-13

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