3IJ4

Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005272	molecular_function	sodium channel activity
A	0006814	biological_process	sodium ion transport
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1

Chain	Residue
A	LYS212
A	ARG310
A	GLU314

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 467

Chain	Residue
A	THR237
A	THR240

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 468

Chain	Residue
A	GLU299
A	TYR301

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CS A 469

Chain	Residue
A	ASP433
A	CS470
A	CS470
A	CS470
A	ASP433
A	ASP433

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CS A 470

Chain	Residue
A	GLY432
A	GLY432
A	GLY432
A	ASP433
A	ASP433
A	ASP433
A	CS469
A	CS469
A	CS469

---

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC

Chain	Residue	Details
A	TYR304-CYS324

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	352
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4NTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Motif: {"description":"GAS motif; ion selectivity filter","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24507937","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Involved in channel desensitization; the process by which the channel becomes unresponsive to proton stimulation","evidences":[{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Involved in proton-dependent gating","evidences":[{"source":"UniProtKB","id":"P78348","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"17882215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22760635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22842900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QTS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---