3IIZ

X-ray structure of the FeFe-hydrogenase maturase HydE from T. maritima in complex with S-adenosyl-L-methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0042364	biological_process	water-soluble vitamin biosynthetic process
A	0044272	biological_process	sulfur compound biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SF4 A 2460

Chain	Residue
A	CYS63
A	CYS67
A	CYS70
A	SAM1501

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAM A 1501

Chain	Residue
A	GLU161
A	ARG180
A	MET199
A	PRO229
A	ILE231
A	TYR303
A	LEU305
A	TYR306
A	HOH458
A	HOH464
A	HOH466
A	HOH475
A	HOH514
A	HOH780
A	SF42460
A	TYR69
A	SER108
A	SER136
A	GLY138
A	ARG159

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE CPS A 1701

Chain	Residue
A	GLN98
A	PHE99
A	GLY100
A	LYS102
A	GLU280
A	ARG284
A	MET324
A	LYS325
A	LEU329
A	LEU330
A	HOH455
A	HOH491
A	HOH517
A	HOH541
A	HOH553
A	HOH672
A	HOH754
A	HOH777
A	CPS1703
A	CPS1704
A	CPS1705

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CPS A 1702

Chain	Residue
A	LYS37
A	ASP40
A	LYS170
A	ARG284
A	SER297
A	LYS315
A	ASP316
A	THR317
A	HOH353
A	HOH382
A	HOH414
A	HOH545
A	HOH595
A	HOH623
A	HOH648
A	HOH762

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CPS A 1703

Chain	Residue
A	ARG29
A	GLU33
A	THR247
A	LEU250
A	HOH540
A	HOH544
A	HOH550
A	HOH739
A	HOH782
A	CPS1701
A	CPS1704

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CPS A 1704

Chain	Residue
A	ARG29
A	LYS315
A	THR317
A	ALA318
A	HOH376
A	HOH406
A	HOH418
A	HOH440
A	HOH579
A	HOH675
A	CPS1701
A	CPS1703

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CPS A 1705

Chain	Residue
A	LYS128
A	MET324
A	LYS325
A	GLU328
A	HOH656
A	HOH690
A	HOH723
A	HOH724
A	CPS1701

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES A 2648

Chain	Residue
A	H2S2649
A	H2S2650
A	ARG279
A	CYS311
A	CYS319
A	CYS322
A	VAL323
A	HOH569

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE H2S A 2649

Chain	Residue
A	CYS311
A	CYS319
A	FES2648

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE H2S A 2650

Chain	Residue
A	ARG279
A	CYS322
A	MET326
A	FES2648

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 349

Chain	Residue
A	ARG54
A	THR134
A	ARG155

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 350

Chain	Residue
A	ARG159
A	THR269
A	ALA270
A	TYR306
A	HOH435
A	HOH710

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CO3 A 351

Chain	Residue
A	PHE246
A	HOH499
A	HOH530

---

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	18
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VMKMIELLGRKpgrdwgG

Chain	Residue	Details
A	VAL323-GLY340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18400755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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