3II9
Crystal structure of glutaryl-coa dehydrogenase from Burkholderia pseudomallei at 1.73 Angstrom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| A | 0004361 | molecular_function | glutaryl-CoA dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0000062 | molecular_function | fatty-acyl-CoA binding |
| B | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| B | 0004361 | molecular_function | glutaryl-CoA dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0000062 | molecular_function | fatty-acyl-CoA binding |
| C | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| C | 0004361 | molecular_function | glutaryl-CoA dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| C | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0000062 | molecular_function | fatty-acyl-CoA binding |
| D | 0003995 | molecular_function | acyl-CoA dehydrogenase activity |
| D | 0004361 | molecular_function | glutaryl-CoA dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| D | 0033539 | biological_process | fatty acid beta-oxidation using acyl-CoA dehydrogenase |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046949 | biological_process | fatty-acyl-CoA biosynthetic process |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 396 |
| Chain | Residue |
| A | VAL214 |
| A | HOH433 |
| C | PHE45 |
| C | ALA361 |
| C | ARG362 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 397 |
| Chain | Residue |
| A | HOH492 |
| A | HOH509 |
| A | HOH450 |
| A | HOH463 |
| A | HOH472 |
| A | HOH480 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PGE A 398 |
| Chain | Residue |
| A | LYS36 |
| A | ARG40 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 396 |
| Chain | Residue |
| B | PHE6 |
| B | TRP8 |
| B | ASP9 |
| B | ARG273 |
| B | HOH1101 |
| C | PRO158 |
| C | GLY159 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 B 397 |
| Chain | Residue |
| B | ARG97 |
| B | SER98 |
| B | PHE136 |
| B | LEU138 |
| B | THR139 |
| B | VAL370 |
| B | HOH408 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL B 398 |
| Chain | Residue |
| B | ALA19 |
| B | ARG315 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE C 396 |
| Chain | Residue |
| C | GLY35 |
| C | LYS36 |
| C | ARG40 |
| C | HOH991 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG C 397 |
| Chain | Residue |
| C | GLU121 |
| C | LYS122 |
| C | PRO125 |
| C | LYS126 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 398 |
| Chain | Residue |
| C | LEU205 |
| C | HOH519 |
| C | HOH1007 |
| C | HOH1036 |
| C | HOH1123 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL C 399 |
| Chain | Residue |
| C | SER98 |
| C | TYR373 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG C 400 |
| Chain | Residue |
| C | HOH963 |
| C | HOH964 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 C 401 |
| Chain | Residue |
| C | HIS7 |
| C | TRP8 |
| C | ASP9 |
| C | ARG273 |
| D | GLN388 |
| D | THR389 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 396 |
| Chain | Residue |
| D | LYS36 |
| D | ARG40 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG D 398 |
| Chain | Residue |
| C | ALA387 |
| C | GLN388 |
| D | ARG273 |
| D | LEU277 |
| D | PEG399 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 397 |
| Chain | Residue |
| D | VAL151 |
| D | SER164 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 399 |
| Chain | Residue |
| D | TRP8 |
| D | ASP9 |
| D | PEG398 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG D 400 |
| Chain | Residue |
| D | HOH459 |
Functional Information from PROSITE/UniProt
| site_id | PS00073 |
| Number of Residues | 20 |
| Details | ACYL_COA_DH_2 Acyl-CoA dehydrogenases signature 2. DmLGGnGIsdEfgvaRhlvN |
| Chain | Residue | Details |
| A | ASP347-ASN366 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| A | ALA253 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| B | ALA253 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| C | ALA253 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| D | ALA253 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| A | GLU374 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| B | GLU374 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| C | GLU374 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ivh |
| Chain | Residue | Details |
| D | GLU374 |
