3IHR

Crystal Structure of Uch37

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000723	biological_process	telomere maintenance
A	0003723	molecular_function	RNA binding
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016579	biological_process	protein deubiquitination
A	0021670	biological_process	lateral ventricle development
A	0030901	biological_process	midbrain development
A	0031011	cellular_component	Ino80 complex
A	0031597	cellular_component	cytosolic proteasome complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0033044	biological_process	regulation of chromosome organization
A	0045739	biological_process	positive regulation of DNA repair
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048853	biological_process	forebrain morphogenesis
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070628	molecular_function	proteasome binding
A	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE FMT A 329

Chain	Residue
A	ALA80
A	SER95

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 330

Chain	Residue
A	TRP36
A	SER37
A	LEU38
A	LYS265
A	MSE268

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 331

Chain	Residue
A	ASP75
A	GLN119

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305

Chain	Residue	Details
A	CYS88

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	HIS164

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for enzyme activity => ECO:0000250

Chain	Residue	Details
A	ASP179

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9WUP7

Chain	Residue	Details
A	LYS47
A	HIS289

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS158

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1uch

Chain	Residue	Details
A	ASP179
A	HIS164
A	CYS88
A	GLN82

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