3IHL

Human CTPS2 crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0003883	molecular_function	CTP synthase activity
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP A 300

Chain	Residue
A	ILE14
A	ASP246
A	VAL247
A	VAL253
A	HOH290
A	HOH296
A	PO4301
B	ALA188
B	THR189
A	GLY15
A	LYS16
A	GLY17
A	ILE18
A	LEU107
A	ARG217
A	ILE244
A	HIS245

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 301

Chain	Residue
A	SER12
A	GLY13
A	LYS16
A	GLY148
A	GLY149
A	ADP300

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP B 300

Chain	Residue
A	ALA188
A	THR189
B	GLY13
B	ILE14
B	GLY15
B	LYS16
B	GLY17
B	ILE18
B	ARG217
B	HIS245
B	ASP246
B	VAL247
B	VAL253
B	PO4301

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 301

Chain	Residue
B	GLY13
B	LYS16
B	GLY148
B	GLY149
B	ADP300

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---